The BRAF p.V600E mutation is a common event in ameloblastomas but is absent in odontogenic keratocysts

Examination of the cranial morphology in Bombina orientalis (Anura: Discoglossidae) revealed the occurrence of additional dermal bones lying: a) between the nasals and frontoparietals, b) between frontoparietals, and c) on the tectum synoticum behind the frontoparietals. The presence of similar bones as well as extra ossifications lying in the midline in the rostral portion of skull was shown to be a rather common event among anurans. Based on the occurrence of bones with similar topology in crossopterygians and different stegocephalians, it was concluded that extra ossifications sporadically appearing in anurans are more likely to be ancient cranial elements than neomorphs. Additional dermal bones found in the anterior portion of the anuran skull are homologous to the postrostrals of crossopterygians; extra ossifications lying between the frontoparietals correspond to the bones with similar topology sporadically appearing in crossopterygians and stegocephalians; and extra bones situated behind the frontoparietals are homologous to the lateral extrascapulars (postparietals of stegocephalians) and the median extrascapular of crossopterygians. These extra bones were proposed to be inherited from the presumed common ancestor of all Gnathostomes and retained in anurans in the state of latent capacities. The sporadic appearance of these bones in anurans results from the phenotypical realization of these latent capacities.

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Avoid These Common Event Planning Blunders

Special Events Galore ◽

10.1002/speg.31530 ◽

2021 ◽

Vol 21 (2) ◽

pp. 8-8

Keyword(s):

Common Event ◽

Event Planning

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Changes in Cellular Regulatory Factors before and after Decompression of Odontogenic Keratocysts

Journal of Clinical Medicine ◽

10.3390/jcm10010030 ◽

2020 ◽

Vol 10 (1) ◽

pp. 30

Author(s):

Slmaro Park ◽

Han-Sung Jung ◽

Young-Soo Jung ◽

Woong Nam ◽

Jung Yul Cha ◽

...

Keyword(s):

Recurrence Rate ◽

Biological Behavior ◽

Nuclear Antigen ◽

Epithelial Cyst ◽

Ki 67 ◽

Proliferation Markers ◽

Odontogenic Keratocysts ◽

Wide Range ◽

Before And After ◽

Cyst Lining

Decompression followed by enucleation, which is one of the treatments used for odontogenic keratocysts (OKCs), is frequently used in OKC lesions of large sizes. This method offers the advantage of minimizing the possibility of sensory impairment without creating a wide-range bone defect; moreover, the recurrence rate can be significantly lower than following simple enucleation. This study aimed to assess the changes in histology and expression of proliferation markers in OKCs before and after decompression treatment. A total of 38 OKC tissue samples from 19 patients who had undergone decompression therapy were examined morphologically and immunohistochemically to observe changes in proliferative activity before and after decompression. The markers used for immunohistochemistry (IHC) staining were Bcl-2, epidermal growth factor receptor (EGFR), Ki-67, P53, PCNA, and SMO. The immunohistochemistry positivity of the 6 markers was scored by using software ImageJ, version 1.49, by quantifying the intensity and internal density of IHC-stained epithelium. The values of Bcl-2, Ki-67, P53, proliferating cell nuclear antigen (PCNA), and SMO in OKCs before and after decompression showed no significant change. No correlation between clinical shrinkage and morphologic changes or expression of proliferation and growth markers could be found. There was no statistical evidence that decompression treatment reduces potentially aggressive behavior of OKC within the epithelial cyst lining itself. This might indicate that decompression does not change the biological behavior of the epithelial cyst lining or the recurrence rate.

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Loss of Inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis

Gastroenterology ◽

10.1016/s0016-5085(03)01201-0 ◽

2003 ◽

Vol 125 (4) ◽

pp. 1175-1187 ◽

Cited By ~ 86

Author(s):

Kazunori Shibao ◽

Keiji Hirata ◽

Marie E Robert ◽

Michael H Nathanson

Keyword(s):

Bile Duct ◽

Common Event ◽

Inositol 1,4,5 Trisphosphate

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Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)76473-4 ◽

1987 ◽

Vol 262 (28) ◽

pp. 13620-13626

Author(s):

Y A Hannun ◽

C S Greenberg ◽

R M Bell

Keyword(s):

Signal Transduction ◽

Protein Kinase C ◽

Protein Kinase ◽

Human Platelets ◽

Signal Transduction Pathways ◽

Common Event ◽

Kinase C

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Modeling the Treatment of Glioblastoma Multiforme and Cancer Stem Cells with Ordinary Differential Equations

Computational and Mathematical Methods in Medicine ◽

10.1155/2016/1239861 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11 ◽

Cited By ~ 4

Author(s):

Kristen Abernathy ◽

Jeremy Burke

Keyword(s):

Stem Cells ◽

Glioblastoma Multiforme ◽

Cancer Therapy ◽

Cancer Stem Cells ◽

Differential Equations ◽

Ordinary Differential Equations ◽

Cancer Patients ◽

Tumor Cells ◽

Tumor Recurrence ◽

Common Event

Despite improvements in cancer therapy and treatments, tumor recurrence is a common event in cancer patients. One explanation of recurrence is that cancer therapy focuses on treatment of tumor cells and does not eradicate cancer stem cells (CSCs). CSCs are postulated to behave similar to normal stem cells in that their role is to maintain homeostasis. That is, when the population of tumor cells is reduced or depleted by treatment, CSCs will repopulate the tumor, causing recurrence. In this paper, we study the application of the CSC Hypothesis to the treatment of glioblastoma multiforme by immunotherapy. We extend the work of Kogan et al. (2008) to incorporate the dynamics of CSCs, prove the existence of a recurrence state, and provide an analysis of possible cancerous states and their dependence on treatment levels.

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