Reproducibility of a Long-Range Swept-Source Optical Coherence Tomography Ocular Biometry System and Comparison with Clinical Biometers

Purpose: To compare central corneal thickness (CCT) measurements and their reproducibility when taken by Ultrasound Pachymetry, Ocular Biometry and Angiovue Optical Coherence Tomography (OCT). Methods: Twenty-five healthy volunteers were recruited creating a sample size of 50 eyes. All subjects had pachymetric measurements by Ultrasound pachymetry (PachPen Handheld Pachymeter, Keeler Instruments Inc), Ocular biometry (IOL Master 700 Swept Source Biometry, Zeiss) and Angiovue Optical Coherence Tomography (Optovue Avanti RTVue XR Angiovue). The measurements of central corneal thickness for the three devices were taken by the same examiner twice for more accuracy. Results: The average measurements of central corneal thickness by Ultrasound pachymetry (PachPen Handheld Pachymeter, Keeler Instruments Inc), Ocular biometry (IOL Master 700 Swept Source Biometry, Zeiss) and Angiovue Optical Coherence Tomography (Optovue Avanti RTVue XR Angiovue) were 547.26 μm, 551.36 μm, and 536.42 μm, respectively. The mean standard deviation (SD) of repeated measurements by Ocular biometry was 48.87 μm, which was greater than the mean SD of 44.24 μm and 40.35 μm (P < 0.001) by ultrasound pachymetry and Angiovue optical coherence tomography, respectively. There were statistically significant differences in the measurement results among the 3 methods (Ultrasound pachymetry vs. Ocular biometry P = 0.019; Ultrasound pachymetry vs. Angiovue Optical Coherence Tomography; P < 0.001; Ocular biometry vs. Angiovue Optical Coherence Tomography P < 0.001). There was a significant linear correlation between the Ultrasound pachymetry and Ocular biometry (r = 0.945, P<0.001), Ultrasound pachymetry and Angiovue Optical Coherence Tomography (r = 0.895, P<0.001), and Ocular biometry and Angiovue Optical Coherence Tomography (r = 0.902, P<0.001). Conclusion: Central corneal thickness readings were comparable between PachPen Handheld Pachymeter, IOL Master 700 Biometry and Angiovue Optical Coherence Tomography; Angiovue optical coherence tomography gave significantly smaller values. The measurements of the 3 methods showed significant linear correlations with one another. All methods provided acceptable repeatability of measurements.

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Author Correction: Ocular biometry and refractive outcomes using two swept-source optical coherence tomography-based biometers with segmental or equivalent refractive indices

Scientific Reports ◽

10.1038/s41598-020-69871-6 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Miki Kamikawatoko Omoto ◽

Hidemasa Torii ◽

Sachiko Masui ◽

Masahiko Ayaki ◽

Kazuo Tsubota ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Refractive Indices ◽

Optical Coherence ◽

Swept Source ◽

Refractive Outcomes ◽

Ocular Biometry

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Front Cover: Robust numerical phase stabilization for long-range swept-source optical coherence tomography (J. Biophotonics 11/2017)

Journal of Biophotonics ◽

10.1002/jbio.201770110 ◽

2017 ◽

Vol 10 (11) ◽

pp. 1389-1389

Keyword(s):

Optical Coherence Tomography ◽

Long Range ◽

Optical Coherence ◽

Swept Source ◽

Front Cover ◽

Phase Stabilization

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Lens nuclear opacity quantitation with long-range swept-source optical coherence tomography: correlation to LOCS III and a Scheimpflug imaging-based grading system

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-312661 ◽

2018 ◽

Vol 103 (8) ◽

pp. 1048-1053 ◽

Cited By ~ 5

Author(s):

Ding Chen ◽

Zhangliang Li ◽

Jinhai Huang ◽

Liuqing Yu ◽

Songjia Liu ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Long Range ◽

Intraclass Correlation ◽

Grading System ◽

Nuclear Density ◽

Optical Coherence ◽

Swept Source ◽

Age Related ◽

Scheimpflug Imaging ◽

Nuclear Opacity

PurposeTo quantitate lens nuclear opacity using long-range swept-source optical coherence tomography (SS-OCT) images and to evaluate the correlation of this method to Lens Opacities Classification System III (LOCS III) and a Scheimpflug imaging-based grading system (Pentacam Nuclear Stage function; PNS).MethodsThis study enrolled 120 participants (120 eyes) with age-related nuclear cataracts. The best-corrected visual acuity (BCVA), LOCS III nuclear opalescence (NO) and nuclear colour (NC) were obtained. The nuclear density measured using PNS function (NDPNS) was recorded. Three successive series of long-range SS-OCT images were captured, and the nuclear region was analysed using ImageJ (NIH, Bethesda, Maryland, USA) to generate SS-OCT image-based nuclear density (NDSS-OCT). The repeatability of NDSS-OCT measurement was evaluated using within-subject coefficient of variation (CVw) and intraclass correlation coefficient (ICC). Correlations of NDSS-OCT with NO and NC, BCVA and NDPNS were analysed. According to the integrity of nucleus imaged by Pentacam, patients were divided into two groups, and the parameters were compared between groups.ResultsThe CVw and ICC for NDSS-OCT measurement were 1.5 % and 0.994, respectively. The NDSS-OCT significantly correlated with NO (r=0.831), NC (r=0.873), BCVA (r=0.655) and NDPNS (r=0.891). The NDSS-OCT, NO and NC, and BCVA were significantly different between the two groups.ConclusionLens nuclear opacity quantitation using long-range SS-OCT images was repeatable and correlated well with LOCS III and PNS function. The Scheimpflug principle had a limitation in imaging dense nucleus. Long-range SS-OCT seems more promising for objectively and quantitatively assessing lens nuclear opacity.

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Robust numerical phase stabilization for long-range swept-source optical coherence tomography

Journal of Biophotonics ◽

10.1002/jbio.201700034 ◽

2017 ◽

Vol 10 (11) ◽

pp. 1398-1410 ◽

Cited By ~ 17

Author(s):

Shaozhen Song ◽

Jingjiang Xu ◽

Shaojie Men ◽

Tueng T. Shen ◽

Ruikang K. Wang

Keyword(s):

Optical Coherence Tomography ◽

Long Range ◽

Optical Coherence ◽

Swept Source ◽

Phase Stabilization

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Effects of 0.01% Atropine Instillation Assessed Using Swept-Source Anterior Segment Optical Coherence Tomography

Journal of Clinical Medicine ◽

10.3390/jcm10194384 ◽

2021 ◽

Vol 10 (19) ◽

pp. 4384

Author(s):

Tadahiro Mitsukawa ◽

Yumi Suzuki ◽

Yosuke Momota ◽

Shun Suzuki ◽

Masakazu Yamada

Keyword(s):

Optical Coherence Tomography ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Eye Drops ◽

Optical Coherence ◽

Short Term ◽

Swept Source ◽

Tomography System ◽

Ocular Biometry ◽

History Of

In this paper, we assessed the short-term effects of 0.01% atropine eye drops on anterior segment parameters by performing ocular biometry using a swept-source anterior segment optical coherence tomography system (AS-OCT). We recruited 17 healthy volunteers (10 men and 7 women aged 24–35 years) with no history of eye disease. Participants without accommodative demand demonstrated significant mydriasis 1 h after the atropine instillation (4.58 ± 0.77 to 5.41 ± 0.83 mm). Pupil diameters with a 5 diopter (D) accommodative stimulus at 1 h (4.70 ± 1.13 mm) and 24 h (4.05 ± 1.06 mm) after atropine instillation were significantly larger than those at baseline (3.71 ± 0.84 mm). Barring pupil diameter, no other biometric parameters significantly changed at any point in time after atropine instillation without accommodative demand. However, with an accommodative stimulus, anterior chamber depth (ACD) at 1 h and posterior curvature of the lens at 1 and 24 h were both significantly larger than those before atropine instillation. Using AS-OCT, we detected a slight decrease in the accommodation response of ocular biometric components evoked by 0.01% atropine instillation. Morphologically, our measurements suggested a change in the ACD and horizontal radius of the lens’ posterior surface curvatures due to the subtle reduction of accommodation.

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