Lens nuclear opacity quantitation with long-range swept-source optical coherence tomography: correlation to LOCS III and a Scheimpflug imaging-based grading system

2018 ◽  
Vol 103 (8) ◽  
pp. 1048-1053 ◽  
Author(s):  
Ding Chen ◽  
Zhangliang Li ◽  
Jinhai Huang ◽  
Liuqing Yu ◽  
Songjia Liu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Long Range ◽  
Intraclass Correlation ◽  
Grading System ◽  
Nuclear Density ◽  
Optical Coherence ◽  
Swept Source ◽  
Age Related ◽  
Scheimpflug Imaging ◽  
Nuclear Opacity

PurposeTo quantitate lens nuclear opacity using long-range swept-source optical coherence tomography (SS-OCT) images and to evaluate the correlation of this method to Lens Opacities Classification System III (LOCS III) and a Scheimpflug imaging-based grading system (Pentacam Nuclear Stage function; PNS).MethodsThis study enrolled 120 participants (120 eyes) with age-related nuclear cataracts. The best-corrected visual acuity (BCVA), LOCS III nuclear opalescence (NO) and nuclear colour (NC) were obtained. The nuclear density measured using PNS function (NDPNS) was recorded. Three successive series of long-range SS-OCT images were captured, and the nuclear region was analysed using ImageJ (NIH, Bethesda, Maryland, USA) to generate SS-OCT image-based nuclear density (NDSS-OCT). The repeatability of NDSS-OCT measurement was evaluated using within-subject coefficient of variation (CVw) and intraclass correlation coefficient (ICC). Correlations of NDSS-OCT with NO and NC, BCVA and NDPNS were analysed. According to the integrity of nucleus imaged by Pentacam, patients were divided into two groups, and the parameters were compared between groups.ResultsThe CVw and ICC for NDSS-OCT measurement were 1.5 % and 0.994, respectively. The NDSS-OCT significantly correlated with NO (r=0.831), NC (r=0.873), BCVA (r=0.655) and NDPNS (r=0.891). The NDSS-OCT, NO and NC, and BCVA were significantly different between the two groups.ConclusionLens nuclear opacity quantitation using long-range SS-OCT images was repeatable and correlated well with LOCS III and PNS function. The Scheimpflug principle had a limitation in imaging dense nucleus. Long-range SS-OCT seems more promising for objectively and quantitatively assessing lens nuclear opacity.

scholarly journals The Spectrum of Central Choriocapillaris Abnormalities on Swept-Source Optical Coherence Tomography Angiography in the Fellow Eye of Unilateral Exudative Age-Related Macular Degeneration Patients: From Flow Deficits to Subclinical Non-Exudative Neovascularization

2021 ◽  
Vol 10 (12) ◽  
pp. 2658
Author(s):  
Alexis Khorrami Kashi ◽  
Eric Souied ◽  
Selim Fares ◽  
Enrico Borrelli ◽  
Vittorio Capuano ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Clinical Findings ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Swept Source ◽  
Exudative Amd ◽  
Age Related ◽  
Fellow Eyes

We evaluated the spectrum of choriocapillaris (CC) abnormalities in the fellow eyes of unilateral exudative age-related macular degeneration (AMD) patients using swept-source optical coherence tomography angiography (SS-OCTA). Fellow eyes of unilateral exudative AMD patients were prospectively included between May 2018 and October 2018. Patients underwent a multimodal imaging including a SS-OCTA. Demographics and clinical findings were analyzed. The estimated prevalence of macular neovascularization (MNV) was computed. Number and size of flow deficits (FDs) and percentage of flow deficits (FD%) were computed on the compensated CC flow images with the Fiji software. We included 97 eyes of 97 patients (mean age was 80 ± 7.66 years, 39 males, 58 females). The prevalence of MNV in the studied eyes was 8.25% (8/97 eyes). In the 89 non-neovascular eyes, FD% averaged 45.84% ± 11.63%, with a corresponding total area of FDs of 4.19 ± 1.12 mm2. There was a higher prevalence of drusenoid pigment epithelial detachment in eyes with subclinical neovascularization (p = 0.021). Fellow eyes with unilateral exudative AMD encompassed a series of CC abnormalities, from FDs of the aging CC to subclinical non-exudative MNV.

scholarly journals Objective quantification of lens nuclear opacities using swept-source anterior segment optical coherence tomography

2021 ◽  
pp. bjophthalmol-2020-318334
Author(s):  
Wei Wang ◽  
Jiaqing Zhang ◽  
Xiaoxun Gu ◽  
Xiaoting Ruan ◽  
Xiaoyun Chen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Anterior Segment ◽  
Training Dataset ◽  
Dissipated Energy ◽  
Nuclear Density ◽  
Optical Coherence ◽  
Nuclear Cataract ◽  
Swept Source ◽  
Ultrasonic Time

Background/aimsThe primary objective is to quantify the lens nuclear opacity using swept-source anterior segment optical coherence tomography (SS-ASOCT) and to evaluate its correlations with Lens Opacities Classification System III (LOCS-III) system and surgical parameters. The secondary objective is to assess the diagnostic performance for hard nuclear cataract.MethodsThis cross-sectional study included 1222 patients eligible for cataract surgery (1222 eyes). The latest SS-ASOCT (CASIA-2) was used to obtain high-resolution lens images, and the average nuclear density (AND) and maximum nuclear density (MND) were measured by a custom ImageJ software. Spearman’s correlations analysis was used to assess associations of AND/MND with LOCS-III nuclear scores, visual acuity and surgical parameters. The subjects were then split randomly (9:1) into the training dataset and validating dataset. Receiver operating characteristic curves and calibration curves were constructed for the classification on hard nuclear cataract.ResultsThe AND and MND from SS-ASOCT images were significantly correlated with nuclear colour scores (AND: r=0.716; MND: r=0.660; p<0.001) and nuclear opalescence scores (AND: r=0.712; MND: r=0.655; p<0.001). The AND by SS-ASOCT images had the highest values of Spearman’s r for preoperative corrected distance visual acuity (r=0.3131), total ultrasonic time (r=0.3481) and cumulative dissipated energy (r=0.4265). The nuclear density had good performance in classifying hard nuclear cataract, with area under the curves of 0.859 (0.831–0.886) for AND and 0.796 (0.768–0.823) for MND.ConclusionObjective and quantitative evaluation of the lens nuclear density using SS-ASOCT images enable accurate diagnosis of hard nuclear cataract.

Choroidal changes in intermediate age-related macular degeneration patients with drusen or pseudodrusen

2020 ◽  
pp. 112067212091453 ◽  
Author(s):  
Raffaella Rosa ◽  
Paolo Corazza ◽  
Maria Musolino ◽  
Chiara Mochi ◽  
Guido Maiello ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Flow Area ◽  
Swept Source ◽  
Reticular Pseudodrusen ◽  
Vascular Flow ◽  
Age Related

Reticular pseudodrusen are associated with a thinner choroid. The aim of our study was to determine the differences in central choroidal thickness and choriocapillaris vascular flow area between eyes with and without reticular pseudodrusen using swept-source optical coherence tomography and swept-source optical coherence tomography angiography. We conducted a retrospective case control study which included 27 eyes from 27 consecutive patients with intermediate age-related macular degeneration and 17 eyes from 17 healthy participants. Complete ophthalmic examinations were carried out including axial length measurements; fundus color retinography; fundus autofluorescence; swept-source optical coherence tomography and swept-source optical coherence tomography angiography; central choroidal thickness and choriocapillaris vascular flow area. Patients were classified as no reticular pseudodrusen, mild reticular pseudodrusen, and severe reticular pseudodrusen. Mean central choroidal thickness in patients exhibiting severe reticular pseudodrusen (110 ± 56 μm) was significantly smaller than in patients with no reticular pseudodrusen (201 ± 76 μm, p < 0.01). Mean choriocapillaris vascular flow area in severe reticular pseudodrusen patients (45.2% ± 3.0%) was also significantly less than in patients with no (47.9% ± 1.6%, p < 0.001) and mild reticular pseudodrusen (47.7% ± 1.0%, p < 0.05). Stepwise multiple regression models confirmed the association of reticular pseudodrusen with central choroidal thickness (p < 0.001) and choriocapillaris vascular flow area (p < 0.01) even after accounting for age, axial length, and refractive error. Soft drusen were not associated with changes in either central choroidal thickness (p = 0.13) nor choriocapillaris vascular flow area (p = 0.29). A significant, positive relationship was found between central choroidal thickness and choriocapillaris vascular flow area (r = 0.44, p = 0.01). Therefore, both central choroidal thickness and choriocapillaris vascular flow area are decreased in eyes with reticular pseudodrusen, as compared to healthy eyes and intermediate age-related macular degeneration eyes not exhibiting reticular pseudodrusen. In addition, central choroidal thickness and choriocapillaris vascular flow area are related, and the reduction of either is directly associated to the severity of reticular pseudodrusen. Further studies are needed to assess the clinical significance of these findings.

scholarly journals Swept Source Optical Coherence Tomography Assessment of Bursa Premacularis in Healthy Eyes

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Paolo Carpineto ◽  
Rossella D’Aloisio ◽  
Daniele Guarini ◽  
Carla Iafigliola ◽  
Luca Cerino ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraclass Correlation ◽  
Optical Coherence ◽  
High Definition ◽  
Swept Source ◽  
Visualization Software ◽  
En Face ◽  
Bursa Premacularis ◽  
Youth Population ◽  
En Face Imaging

Purpose. To describe the reliability and the limits of bursa premacularis (BPM) evaluation using a swept source optical coherence tomography (SS-OCT) device with enface and 16 mm-high definition (HD) longitudinal scans. Methods. 60 eyes of 60 subjects were enrolled and imaged with SS-OCT system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). BPM area was measured using enface scans imported to ImageJ. HD horizontal and vertical longitudinal scans centered at the fovea were used to detect width (W) and central thickness (CT) of BPM at baseline (T0) and after 30 minutes (T30) performed by two different observers. An enhanced vitreous visualization software provided by the manufacturer of the device was used to highlight vitreous structures. Results. BPM was identifiable in 100% of eyes using both horizontal and vertical longitudinal scans. On horizontal scan, BPM was not entirely measurable in 21.7% and in 18.3% of cases at T0 and T30, respectively. On vertical scan, BPM was not entirely measurable in 75.0% and in 81.7% at T0 and T30, respectively. No statistically significant differences were found between the two different time measurements with an intraclass correlation coefficient above 70%. Median BPM area was 26.9 (Q1-Q3: 19.5-40.5) mm2. In en face imaging, the most frequent BPM shape was the boat one. Conclusion. SS-OCT is a reliable tool for a detailed quantification and mapping of BPM, and it is able to add useful details about the morphological BPM features in youth population. However, the enhanced visualization of the vitreous structures is still a challenge, also with the most forefront devices.

Diurnal Variation in Choroidal and Retinal Thickness of the Early Treatment of Diabetic Retinopathy Study Macular Subfields Determined Using Swept-Source Optical Coherence Tomography

2015 ◽  
Vol 233 (3-4) ◽  
pp. 192-197 ◽  
Author(s):  
Yong-Seop Han ◽  
Hyung-Bin Lim ◽  
Soo-Hyun Lee ◽  
Jung-Yeul Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Diurnal Variation ◽  
Early Treatment ◽  
Retinal Thickness ◽  
Intraclass Correlation ◽  
Optical Coherence ◽  
Swept Source ◽  
A Prospective Study ◽  
Significant Diurnal Variation

Purpose: To describe diurnal variation in choroidal thickness (CT) and retinal thickness (RT) of the nine Early Treatment of Diabetic Retinopathy Study (ETDRS) macular subfields determined using swept-source optical coherence tomography. Methods: A prospective study was conducted on 24 healthy Korean volunteers who underwent two sequential measurements of a randomly selected eye at 9 a.m., 1 p.m., and 6 p.m. The radial scan mode was used. To determine the repeatability and reliability, we applied intragrader agreement using the intraclass correlation coefficient (ICC). Results: Significant diurnal variation in CT was observed. The highest mean CT was found at 9 a.m. The lowest mean CT occurred at 1 p.m. There was excellent intragrader agreement, with the ICC ranging from 0.961 to 0.997. There was no significant diurnal variation in RT. Conclusion: There was significant diurnal variation in CT. The choroid was thinner at 1 p.m. than at 9 a.m. and 6 p.m.

scholarly journals Reproducibility of a Long-Range Swept-Source Optical Coherence Tomography Ocular Biometry System and Comparison with Clinical Biometers

Ophthalmology ◽  
2013 ◽  
Vol 120 (11) ◽  
pp. 2184-2190 ◽  
Author(s):  
Ireneusz Grulkowski ◽  
Jonathan J. Liu ◽  
Jason Y. Zhang ◽  
Benjamin Potsaid ◽  
Vijaysekhar Jayaraman ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Long Range ◽  
Optical Coherence ◽  
Swept Source ◽  
Ocular Biometry
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