scholarly journals Clinicopathological characteristics and outcome of 31 patients with ETV6-NTRK3 fusion gene confirmed (mammary analogue) secretory carcinoma of salivary glands

Oral Oncology ◽  
2018 ◽  
Vol 82 ◽  
pp. 29-33 ◽  
Author(s):  
E. Boon ◽  
M.H. Valstar ◽  
W.T.A. van der Graaf ◽  
E. Bloemena ◽  
S.M. Willems ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Fusion Gene ◽  
Clinicopathological Characteristics ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma

scholarly journals Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Takako Inaba ◽  
Yuki Fukumura ◽  
Tsuyoshi Saito ◽  
Junkichi Yokoyama ◽  
Shinichi Ohba ◽  
...  
Keyword(s):  
Case Report ◽  
Tumor Cells ◽  
Fusion Gene ◽  
Needle Aspiration ◽  
Zymogen Granule ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Secretion Granules ◽  
Cytological Features ◽  
Needle Aspiration Cytology

Mammary analogue secretory carcinoma (MASC) is a recently recognized tumor of salivary glands characterized by the ETV6-NTRK3 fusion gene. This tumor is very rare in children and adolescents. We report a case of MASC in a 15-year-old girl, the fifth youngest case so far reported. The patient complained of a left infra-auricular mass that gradually enlarged for a year. Fine-needle aspiration cytology/imprint cytology showed individual tumor cells that had faintly eosinophilic granular cytoplasm with secretion granules sometimes seen adjacent to the tumor cells. These cytological features overlapped between those of zymogen granule-poor acinic cell carcinoma (AciCC) and MASC. In addition to the case report, we present a review of the related literature with a focus on the cytological features of MASC. The differential diagnostic clues are also discussed.

Mammary Analogue Secretory Carcinoma of Salivary Glands

2016 ◽  
Vol 40 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Alena Skálová ◽  
Tomas Vanecek ◽  
Roderick H.W. Simpson ◽  
Jan Laco ◽  
Hanna Majewska ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma

scholarly journals Clinicopathological Characteristics and Outcomes of 23 Patients with Secretory Carcinoma of Major Salivary Glands

2021 ◽  
Author(s):  
Jingjing Sun ◽  
Sirui Liu ◽  
Kun Fu ◽  
Ning Gao ◽  
Rui Li ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Clinicopathological Characteristics ◽  
Secretory Carcinoma ◽  
Survival Prognosis ◽  
Ki 67 ◽  
S 100 ◽  
Locoregional Recurrence Rate ◽  
Node Metastases

Abstract This retrospective study investigated the clinicopathological characteristics of secretory carcinoma of salivary glands (SCSG) in 23 patients with histopathologically confirmed SCSG between January 2010 and December 2020. In total, 13 males and 10 females were enrolled (ratio, 1.3:1) from 10 to 69 years of age (median 45 y); the average disease duration was 2.44 y (0.25–20 y). Twenty-one patients (91.3%) had SCSG in the parotid gland, and two (8.7%) in the submandibular gland. All patients had single nodules with diameters of 0.8–4.8 cm (average 2.6 cm); five with lymph node metastases, and two with distant metastases. Immunohistochemically, tumors stained positive for S-100, mammaglobin, CK7, and GATA3, and negative for DOG1, P63, and calponin, with Ki-67 positivity from 1–50%. ETV6 gene rearrangement was confirmed in 15 patients. All patients underwent oncological resection, four had radioactive particles implanted postoperatively, one received chemotherapy, and seven underwent chemoradiotherapy. Six patients had regional recurrences, two distant metastases, and one died before the last follow-up. SCSGs are typically indolent, with a low locoregional recurrence rate and excellent survival. Prognosis is correlated to clinical stage, pathological grade, and surgical procedures.

Sign in / Sign up

Export Citation Format

Share Document