Exome sequencing reveals candidate mutations implicated in sinonasal carcinoma and malignant transformation of sinonasal inverted papilloma

Oral Oncology ◽  
2022 ◽  
Vol 124 ◽  
pp. 105663
Author(s):  
Sanna Viitasalo ◽  
Piia-Riitta Karhemo ◽  
Juho Väänänen ◽  
Taru Ilmarinen ◽  
Markus Lilja ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Malignant Transformation ◽  
Inverted Papilloma ◽  
Sinonasal Carcinoma ◽  
Sinonasal Inverted Papilloma

Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma

2019 ◽  
Vol 161 (6) ◽  
pp. 1036-1042 ◽  
Author(s):  
Ivy W. Maina ◽  
Charles C. L. Tong ◽  
Esther Baranov ◽  
Neil N. Patel ◽  
Vasiliki Triantafillou ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Recurrence Rate ◽  
Carcinoma In Situ ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma ◽  
Definitive Surgery ◽  
Severe Degree ◽  
Multiple Recurrences

Objective Sinonasal inverted papilloma (IP) is a typically benign sinonasal tumor with a tendency to recur and the potential for malignant transformation. Varying degrees of dysplasia may be present, of which carcinoma in situ (CIS) is most advanced. We hereby describe the biological and clinical behavior of IP with CIS (IPwCIS). Study Design Retrospective cohort. Setting Tertiary academic referral center. Subjects and Methods Patients who underwent surgical resection for IP between 2002 and 2017. Pertinent clinical data were obtained, and all IPwCIS cases were histologically confirmed. Results In total, 37 of 215 cases (17.2%) were identified with IPwCIS. Mean age was 57 years and 86.5% of patients were male. Median follow-up was 82 months, and the recurrence rate was 27%. The maxillary sinus was the most common primary site (37.8%) and 14 tumors (37.8%) demonstrated multifocal attachment, which was associated with recurrence (odds ratio [OR], 9.7; 95% confidence interval [CI], 1.4-112.8; P = .028). IPwCIS was also associated with multiple recurrences (OR, 2.71; 95% CI, 1.246-5.814; P = .021). Most patients were treated with surgery alone (89.1%) and 4 patients received adjuvant radiotherapy (8.1%). Only 1 patient (2.7%) demonstrated malignant transformation after definitive surgery. Conclusions IPwCIS represents the most severe degree of dysplasia prior to malignant transformation and is associated with higher recurrence rate and multifocal involvement but low rate of conversion to invasive carcinoma. The need for adjuvant therapy remains controversial, and further research into the etiology of the disease is warranted.

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

2017 ◽  
Vol 274 (8) ◽  
pp. 2991-3000 ◽  
Author(s):  
M. Re ◽  
F. M. Gioacchini ◽  
A. Bajraktari ◽  
M. Tomasetti ◽  
S. Kaleci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Genetic Alterations ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

scholarly journals Risk Factors of Recurrence and Malignant Transformation of Sinonasal Inverted Papilloma

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Marta Gamrot-Wrzoł ◽  
Paweł Sowa ◽  
Grażyna Lisowska ◽  
Wojciech Ścierski ◽  
Maciej Misiołek
Keyword(s):  
Malignant Transformation ◽  
Clinical Medicine ◽  
Surgical Techniques ◽  
Diagnostic Techniques ◽  
Postoperative Management ◽  
Inverted Papilloma ◽  
Surgical Approaches ◽  
Ki 67 ◽  
Wnt Proteins ◽  
Sinonasal Inverted Papilloma

Sinonasal inverted papilloma is a relatively rare disease; however, it is prevalent enough for every ENT practitioner to encounter it several times throughout medical routines. Despite the developments in experimental and clinical medicine as well as surgical techniques, our knowledge of this disease is still inadequate. With improved imaging and better diagnostic techniques, proper diagnosis and qualification for surgical approaches leave no doubt. Although the endoscopic approach seems to be the gold standard for such condition, some cases may additionally require an external approach. Regardless of the type of surgery, postoperative management is crucial for both healing and long-term follow-up. Unfortunately, the procedures are still lacking in explicit and standardized postoperative management guidelines. Moreover, an important issue is still the need for a biomarker indicative of inverted papilloma and its malignant transformation. Several particles, within the spotlight of the researchers, have been SCCA, Ki-67, Bcl-2, Wnt proteins, and many more. Nevertheless, the topic requires further investigations.

scholarly journals Sinonasal Inverted Papilloma and the Dilemma of Treatments

2013 ◽  
Vol 6 (2) ◽  
pp. 61-63
Author(s):  
Bandar Al Qahtani ◽  
Mariam S Al-Amro
Keyword(s):  
Malignant Transformation ◽  
Recent Literature ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

ABSTRACT This is a review of most recent literature to find the best methods for management of sinonasal inverted papilloma and if there is any standardized modality/modalities. Also there is concern about the advancement in the management of sinonasal inverted papilloma based on recent literature revision. Inverted papilloma has to be managed aggressively from the beginning putting in mind its ability to recur and malignant transformation. Until now days there is no single verified modality of treatment and the choice of the best approach is tailored to every case. How to cite this article Al-Qahtani BM, Al-Amro MS. Sinonasal Inverted Papilloma and the Dilemma of Treatments. Clin Rhinol An Int J 2013;6(2):61-63.

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