scholarly journals “Shear movement at the fracture site delays healing in a diaphyseal fracture model” by Peter Augat, Johannes Buger, Sandra Schorlemmer, Thomas Henke, Manfred Peraus, Lutz Claes [J Orthop Res 2003;21:1011–17]

2004 ◽  
Vol 22 (5) ◽  
pp. 1156-1157 ◽  
Author(s):  
S.-H. Park
2003 ◽  
Vol 21 (6) ◽  
pp. 1011-1017 ◽  
Author(s):  
Peter Augat ◽  
Johannes Burger ◽  
Sandra Schorlemmer ◽  
Thomas Henke ◽  
Manfred Peraus ◽  
...  

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Shintaro Shoji ◽  
Kentaro Uchida ◽  
Wataru Satio ◽  
Hiroyuki Sekiguchi ◽  
Gen Inoue ◽  
...  

Abstract Background An enzymatic crosslinking strategy using hydrogen peroxide and horseradish peroxidase is receiving increasing attention for application with in situ-formed hydrogels (IFHs). Several studies have reported the application of IFHs in cell delivery and tissue engineering. IFHs may also be ideal carrier materials for bone repair, although their potential as a carrier for bone morphogenetic protein (BMP)-2 has yet to be examined. Here, we examined the effect of an IFH made of hyaluronic acid (IFH-HA) containing BMP-2 in promoting osteogenesis in a mouse refractory fracture model. Methods Immediately following a fracture procedure, animals either received no treatment (control) or an injection of IFH-HA/PBS or IFH-HA containing 2 μg BMP-2 (IFH-HA/BMP-2) into the fracture site (n = 16, each treatment). Results Fracture sites injected with IFH-HA/BMP-2 showed significantly greater bone volume, bone mineral content, and bone union compared with sites receiving no treatment or treated with IFH-HA/PBS alone (each n = 10). Gene expression levels of osteogenic markers, Alpl, Bglap, and Osx, were significantly raised in the IFH-HA/BMP-2 group compared to the IFH-HA/PBS and control groups (each n = 6). Conclusion IFH-HA/BMP-2 may contribute to the treatment of refractory fractures.


2013 ◽  
Vol 7 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Saikat Sarkar ◽  
Ranadeb Bandyopadhyay ◽  
Arindam Mukherjee

Background: Femoral shaft fracture is the most common major paediatric orthopaedic. For generations traction and casting was the standard treatment for all femoral shaft fractures in children. Over the past two decades the advantages of fixation and rapid mobilisation have been increasingly recognised. Methods: A prospective study was conducted in five private hospitals in the district of Bankura, West Bengal over a period of two years (April 2010 to March 2012) on 70 patients with closed shaft femur fractures between 6- 14 years age of either sex. The aim was to find out the short term complications of titanium elastic nailing in diaphyseal fracture of femur in children and compare the findings of this study with pre- existing studies in this field. Results: In our study the most common complication was pain at nail entry site (60%). 5.71% had local inflammatory reaction due to nails. Superficial infection occurred in 2.85%. At the end of 1 year, 2.85% had limb length discripancies. Proximal migration occurred in 2.85%. 2.85% encountered acute reactive synovitis, 5.71% developed angulation of fracture site and 2.85% developed per operative breakage of nail. Conclusion: The treatment of paediatric shaft femur fracture has been drastically changed over the last two decades to internal fixation by elastically stable intra- medullary nail (ESIN). In our study, we encountered only a few complications most of them being minor. Most of the complications were surgical technique related and were seen at the initial phase of the learning curve.


2016 ◽  
Vol 45 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Timothy J. Preston ◽  
Mark Glyde ◽  
Giselle Hosgood ◽  
Robert E. Day

2018 ◽  
Vol 31 (03) ◽  
pp. 176-181
Author(s):  
Amanda Wagoner ◽  
Matthew Allen ◽  
Claudia Zindl ◽  
Alan Litsky ◽  
Robert Orsher ◽  
...  

Objectives Various materials are used to construct splints for mid-diaphyseal tibial fracture stabilization. The objective of this study was to compare construct stiffness and inter-fragmentary bone motion when fibreglass (FG) or thermoplastic (TP) splints are applied to either the lateral or cranial aspect of the tibia in a mid-diaphyseal fracture model. Methods A coaptation bandage was applied to eight cadaveric canine pelvic limbs, with a custom-formed splint made of either FG or TP material applied to either the lateral or cranial aspect of the osteotomized tibia. Four-point bending tests were performed to evaluate construct stiffness and inter-fragmentary motion in both frontal and sagittal planes. Results For a given material, FG or TP, construct stiffness was not affected by splint location. Construct stiffness was significantly greater with cranial FG splints than with cranial TP splints (p < 0.05), but this difference was not significant when comparing splints applied laterally (p = 0.15). Inter-fragmentary motions in the sagittal and frontal planes were similar across splint types for cranial splints, but for lateral splints there was a 64% reduction in frontal plane motion when FG was used as the splint material (p = 0.03). Clinical Significance FG produces a stiffer construct, but the difference is not reflected in a reduction in inter-fragmentary motion. For lateral splints, FG splints are associated with reduced inter-fragmentary motion as compared with TP and may therefore have slight superiority for this application.


2020 ◽  
Author(s):  
Dae-Geun Kim ◽  
Soo Min Kim

Abstract Background: Open reduction and plate fixation is the standard surgery for displaced midshaft clavicle fractures because of biomechanical stability. Implant failure like plate breakage or deformation is the most serious complication of plate fixation. Several plate designs for midshaft clavicle fractures have been introduced, but traditional superior plate has been mostly used.Methods: We generated the clavicle 3D image using the computed tomography (CT) of the left normal clavicle of a 54-year-old female, and then made the comminuted midshaft clavicle fracture model with 10-mm fracture site gap. The fracture model was fixed with 7-hole superior locking compression plate. Finite element analysis (FEA) was performed between the presence (model B) and absence (model A) of screws above the fracture site.Results: The average peak stress from the cantilever bending force was much greater than the peak stress from the axial compression and axial torsion force. This means that the cantilever loading force is the main force which could cause plate breakage or deformation. The maximal stress of the model B was lower than the one of the model A. Therefore, model B showed superior biomechanical property than model A under all loading conditions, especially cantilever bending force.Conclusions: The peak stress of the superior clavicle plate could be decreased just by inserting a small screw into the screw hole above the fracture site.


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