The dependence of triglycerides from the clinical course of chronic pancreatitis

The features of pathogenesis, clinical course and diagnostics of chronic pancreatitis combined with diseases of the cardiovascular system are discussed in the article. Results of the author’s own research on the effectiveness of influence of enzyme replacement therapy on the course of pancreatitis and comorbid pathology are presented. Significant positive dynamics of both manifestations of chronic pancreatitis and cardiovascular diseases, laboratory and instrumental examinations, improvement of patients’ quality of life upon the prescription of pancreatin are noted.

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Quality of life in patients with comorbidity of chronic pancreatitis and chronic obstructive pulmonary disease in presence of smoking

Infusion & Chemotherapy ◽

10.32902/2663-0338-2019-4-18-22 ◽

2019 ◽

pp. 18-22

Author(s):

L. S. Babinets ◽

О. S. Kvasnitska

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Chronic Pancreatitis ◽

Pulmonary Disease ◽

Physical Functioning ◽

Clinical Course ◽

Life Quality ◽

Chronic Obstructive ◽

General Health Status ◽

Obstructive Pulmonary Disease

Background. A combination of chronic pancreatitis and chronic obstructive pulmonary disease is quite common in clinical practice. This has a negative effect on the clinical course of both diseases. Smoking increases risk of chronic pancreatitis development. Purpose of the study. The purpose of this investigation is to learn smoking influence on clinical course and life quality of patients with comorbidity of chronic pancreatitis and chronic obstructive pulmonary disease. Material and methods. 141 patients with chronic pancreatitis with chronic obstructive pulmonary disease and without it had been examinated. 98 patients with chronic pancreatitis with chronic obstructive pulmonary disease were included to the main group. Both diseases were at phase of remission. Results and discussion. 29 (20.6 %) active smokers were among them. All of them are men. The main syndromes in patients with chronic pancreatitis with chronic obstructive pulmonary disease are dyspeptic (85.7%) and astenic (94.9 %), pain syndrome was registered in 83.7 % patients, the equivalents of pain were observed in 16.3 % of patients. Conclusions. Significant decreasing of life quality in patients with comorbidity of chronic pancreatitis and chronic obstructive pulmonary disease was proved: scales of physical functioning, role physical functioning and general health status were significantly decreased in patients with concomitant COPD (р <0.05). Analysis of the GSRS questionnaire revealed a significant (p <0.05) increasing in three of the five scales presented in patients with chronic pancreatitis and COPD, indicating a deterioration of quality of life in case of comorbidity. There were revealed significant decreasing of physical functioning scale and general health status scale (questionnaire SF‑36) and increasing of all scales in GSRS scales (except for the diarrheal syndrome scale). Significant (p <0.05) moderate correlations were found between the scales of physical functioning and role physical functioning and smoking experience, and moderate correlations with the smoking experience of the dyspeptic syndrome score.

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Peculiarities of blood fibrinolytic activity in patients with comorbidity of chronic pancreatitis and coronary heart disease

Herald of Pancreatic Club ◽

10.33149/vkp.2018.02.06 ◽

2018 ◽

Vol 40 (2) ◽

pp. 36-40

Author(s):

D. A. Gontsaryuk

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Chronic Pancreatitis ◽

Clinical Course ◽

Original Data ◽

Cardiac Insufficiency ◽

Atherosclerotic Process ◽

Ischemic Pancreatitis ◽

Fibrinolytic Potential ◽

Proteolytic Capacity

The article presents the original data indicating changes in the fibrinolytic potential in patients with comorbidity of chronic pancreatitis and coronary heart disease. The results indicate that the increased proteolytic capacity (due to the decreased fibrinolysis) and generalization of the atherosclerotic process, activating chronic DIC-syndrome may be considered as factors aggravating the clinical course of chronic pancreatitis, coronary heart disease and chronic cardiac insufficiency, as they promote the risk of cardiovascular events and ischemic pancreatitis.

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Management of Chronic Pancreatitis

10.2310/gastro.5466 ◽

2016 ◽

Author(s):

Darwin L. Conwell ◽

Veeral M. Oza

Keyword(s):

Chronic Pancreatitis ◽

Ct Scan ◽

Pancreatic Duct ◽

Main Pancreatic Duct ◽

Clinical Course ◽

Islet Cells ◽

Pain Mechanisms ◽

Computed Tomographic ◽

Future Challenges ◽

Criteria For Diagnosis

Chronic pancreatitis (CP) is a syndrome that is characterized by inflammation, irreversible fibrosis, and loss of acinar and islet cells. It has also been described as an “enigmatic process of uncertain pathogenesis, unpredictable clinical course, and unclear treatment.” This review describes the epidemiology, diagnosis, diagnostic challenges, differential diagnosis, treatment, complications, and clinical course and prognosis of CP, as well as future challenges. Figures show a computed tomographic (CT) scan of calcific CP, a secretin-enhanced magnetic resonance cholangiopancreatogram showing a dilated and tortuous main pancreatic duct, a CT scan of a large chronic pseudocyst compressing the stomach and pancreas, an endoscopic ultrasound (EUS) image of CP, a retrograde pancreatogram showing a dilated main pancreatic duct with stones and “blunted” side branches, sources of pain in CP, neuropathic pain mechanisms in CP, and an algorithm summarizing treatment of pain in CP. Tables list the TIGAR-O etiologic classification of CP, standard criteria for diagnosis of CP by EUS, Cambridge endoscopic retrograde cholangiopancreatography grading for CP, and a stepwise radiographic and endoscopic diagnostic approach to patients with suspected CP. Key words: bile duct obstruction, chronic pancreatitis, pancreatic calcifications, TIGAR-O system This review contains 8 highly rendered figures, 4 tables, and 54 references.

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