Globus pallidus, but not entopeduncular nucleus, 6-OHDA-induced lesion attenuates L-Dopa-induced dyskinesia in the rat model of Parkinson's disease

2020 ◽  
Vol 197 ◽  
pp. 173013
Author(s):  
Concepció Marin ◽  
Mercè Bonastre ◽  
Mireya Fuentes ◽  
Joaquim Mullol
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Globus Pallidus ◽  
Rat Model ◽  
Entopeduncular Nucleus

scholarly journals Neuronal Entropy-Rate Feature of Entopeduncular Nucleus in Rat Model of Parkinson’s Disease

2016 ◽  
Vol 26 (02) ◽  
pp. 1550038 ◽  
Author(s):  
Olivier Darbin ◽  
Xingxing Jin ◽  
Christof Von Wrangel ◽  
Kerstin Schwabe ◽  
Atsushi Nambu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Normal Condition ◽  
Rat Model ◽  
Neuronal Firing ◽  
Entopeduncular Nucleus ◽  
Motor Processing ◽  
Firing Rates ◽  
Sensory Motor

The function of the nigro-striatal pathway on neuronal entropy in the basal ganglia (BG) output nucleus, i.e. the entopeduncular nucleus (EPN) was investigated in the unilaterally 6-hyroxydopamine (6-OHDA)-lesioned rat model of Parkinson’s disease (PD). In both control subjects and subjects with 6-OHDA lesion of dopamine (DA) the nigro-striatal pathway, a histological hallmark for parkinsonism, neuronal entropy in EPN was maximal in neurons with firing rates ranging between 15 and 25[Formula: see text]Hz. In 6-OHDA lesioned rats, neuronal entropy in the EPN was specifically higher in neurons with firing rates above 25[Formula: see text]Hz. Our data establishes that the nigro-striatal pathway controls neuronal entropy in motor circuitry and that the parkinsonian condition is associated with abnormal relationship between firing rate and neuronal entropy in BG output nuclei. The neuronal firing rates and entropy relationship provide putative relevant electrophysiological information to investigate the sensory-motor processing in normal condition and conditions such as movement disorders.

scholarly journals Altered pallido-pallidal synaptic transmission leads to aberrant firing of globus pallidus neurons in a rat model of Parkinson's disease

2012 ◽  
Vol 590 (22) ◽  
pp. 5861-5875 ◽  
Author(s):  
Cristina Miguelez ◽  
Stéphanie Morin ◽  
Audrey Martinez ◽  
Michel Goillandeau ◽  
Erwan Bezard ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Synaptic Transmission ◽  
Globus Pallidus ◽  
Rat Model

In vivo multimodal (MRI, SPECT) imaging of the 6-OHDA rat model for Parkinson's disease correlated with behavior and histology

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S392-S392
Author(s):  
Nadja Van Camp ◽  
Koen Van Laere ◽  
Ruth Vreys ◽  
Marleen Verhoye ◽  
Erwin Lauwers ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Spect Imaging ◽  
Multimodal Mri

Colchicine Protects Dopaminergic Neurons in a Rat Model of Parkinson's Disease

2012 ◽  
Vol 11 (7) ◽  
pp. 836-843 ◽  
Author(s):  
Mohamed Salama ◽  
Amr Ellaithy ◽  
Basem Helmy ◽  
Mohamed El-Gamal ◽  
Dina Tantawy ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Dopaminergic Neurons

The Dynamics of Nigrostriatal System Damage and Neurobehavioral Changes in the Rotenone Rat Model of Parkinson's Disease

2021 ◽  
Author(s):  
Dmitry Troshev ◽  
Daniil Berezhnoy ◽  
Olga Kulikova ◽  
Denis Abaimov ◽  
Olga Muzychuk ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Nigrostriatal System
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