scholarly journals A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse–axial tubular system

2008 ◽  
Vol 96 (1-3) ◽  
pp. 258-280 ◽  
Author(s):  
Michal Pásek ◽  
Jiři Šimurda ◽  
Clive H. Orchard ◽  
Georges Christé
Keyword(s):  
Guinea Pig ◽  
Cardiac Myocyte ◽  
Tubular System ◽  
Transverse Axial

A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice

1997 ◽  
Vol 273 (3) ◽  
pp. H1595-H1605 ◽  
Author(s):  
J. G. Fewell ◽  
H. Osinska ◽  
R. Klevitsky ◽  
W. Ng ◽  
G. Sfyris ◽  
...  
Keyword(s):  
Treadmill Exercise ◽  
Genetic Manipulation ◽  
Ultrastructural Examination ◽  
Exercise Protocol ◽  
Hypertrophic Response ◽  
Cardiovascular Stress ◽  
Exercise Regimen ◽  
Ventricular Myosin ◽  
Tubular System ◽  
Transverse Axial

Cardiovascular stress in response to treadmill exercise is frequently used to detect cardiac abnormalities that are not readily apparent at rest. Herein we describe a treadmill exercise protocol for mice that allows for quantitation of the performance of an animal and the ability to gather metabolic information in a nonrestraining manner using telemetry implant devices. Transgenic (TG) mice overexpressing ventricular myosin regulatory light chain (MLC2v) were subjected to a 5-wk exercise regimen. The TG mice had significant decreases in their capacity for exercise at relatively high treadmill speeds compared with their nontransgenic (NTG) littermates. There was no indication of a hypertrophic response occurring in TG or NTG animals in response to the exercise protocol, and exercise had no effect on MLC2v phosphorylation. Ultrastructural examination of TG atria showed overtly normal myofibrillar organization but a proliferation of the transverse-axial tubular system. This exercise protocol should prove useful in detecting subtle phenotypes that occur in mice as a result of genetic manipulation of the cardiac compartment.

scholarly journals Action potential propagation in transverse-axial tubular system is impaired in heart failure

2012 ◽  
Vol 109 (15) ◽  
pp. 5815-5819 ◽  
Author(s):  
L. Sacconi ◽  
C. Ferrantini ◽  
J. Lotti ◽  
R. Coppini ◽  
P. Yan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Action Potential ◽  
Action Potential Propagation ◽  
Tubular System ◽  
Transverse Axial

Comparative Pharmacology of Guinea Pig Cardiac Myocyte and Cloned hERG (I Kr ) Channel

2004 ◽  
Vol 15 (11) ◽  
pp. 1302-1309 ◽  
Author(s):  
CHRISTINA DAVIE ◽  
JEAN PIERRE‐VALENTIN ◽  
CHRIS POLLARD ◽  
NICK STANDEN ◽  
JOHN MITCHESON ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Cardiac Myocyte
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