scholarly journals Paediatric obesity and cardiovascular risk factors – A life course approach

2017 ◽  
Vol 2 (4) ◽  
pp. 102-110 ◽  
Author(s):  
Joana Araújo ◽  
Elisabete Ramos
2011 ◽  
Vol 21 (8) ◽  
pp. 589-597 ◽  
Author(s):  
Emily T. Murray ◽  
Gita D. Mishra ◽  
Diana Kuh ◽  
Jack Guralnik ◽  
Stephanie Black ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Julie Horn ◽  
Eirin B. Haug ◽  
Amanda R. Markovitz ◽  
Abigail Fraser ◽  
Lars J. Vatten ◽  
...  

2009 ◽  
Vol 63 (Suppl 2) ◽  
pp. 74-74
Author(s):  
E. T. Lemelin ◽  
G. Mishra ◽  
D. Kuh ◽  
J. Guralnik ◽  
S. Black ◽  
...  

2017 ◽  
Vol 106-107 ◽  
pp. 53-58 ◽  
Author(s):  
Robinson Ramírez-Vélez ◽  
Jorge Enrique Correa-Bautista ◽  
Emilio Villa-González ◽  
Javier Martínez-Torres ◽  
Anthony C. Hackney ◽  
...  

Neurology ◽  
2021 ◽  
Vol 96 (17) ◽  
pp. e2212-e2219
Author(s):  
Kristine Yaffe ◽  
Eric Vittinghoff ◽  
Tina Hoang ◽  
Karen Matthews ◽  
Sherita H. Golden ◽  
...  

ObjectiveCardiovascular risk factors (CVRFs) are associated with increased risk of cognitive decline, but little is known about how early adult CVRFs and those across the life course might influence late-life cognition. To test the hypothesis that CVRFs across the adult life course are associated with late-life cognitive changes, we pooled data from 4 prospective cohorts (n = 15,001, ages 18–95).MethodsWe imputed trajectories of body mass index (BMI), fasting glucose (FG), systolic blood pressure (SBP), and total cholesterol (TC) for older adults. We used linear mixed models to determine the association of early adult, midlife, and late-life CVRFs with late-life decline on global cognition (Modified Mini-Mental State Examination [3MS]) and processing speed (Digit Symbol Substitution Test [DSST]), adjusting for demographics, education, and cohort.ResultsElevated BMI, FG, and SBP (but not TC) at each time period were associated with greater late-life decline. Early life CVRFs were associated with the greatest change, an approximate doubling of mean 10-year decline (an additional 3–4 points for 3MS or DSST). Late-life CVRFs were associated with declines in early late life (<80 years) but with gains in very late life (≥80 years). After adjusting for CVRF exposures at all time periods, the associations for early adult and late-life CVRFs persisted.ConclusionsWe found that imputed CVRFs across the life course, especially in early adulthood, were associated with greater late-life cognitive decline. Our results suggest that CVRF treatment in early adulthood could benefit late-life cognition, but that treatment in very late life may not be as helpful for these outcomes.


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