Introduction. Grover?s disease is characterized by pruriginous polymorphic
rash with a variable course and duration. Although the etiology is still
unknown, the disease is often associated with other dermatoses, malignant
diseases, use of certain medications, as well as immunosuppression. Case
Report. We report a case of a 70-year-old male patient who was referred for
examination to the Clinic of Dermatovenereology Diseases, Clinical Center of
Vojvodina, due to a rash that lasted for nine months. The first lesions on
the skin appeared around the nipples as exudative eczematous plaques. A few
months later, identical lesions appeared on the lower legs. During treatment
with systemic antihistamines and topical corticosteroids, there were
episodes of transient improvements and re-exacerbations. In the meantime,
erythematous brownish, round and oval papules appeared on the abdomen and
the back, accompanied by intense itch. Laboratory findings revealed
eosinophilia and elevated serum immunoglobulin E levels. A skin biopsy of
the back lesion was performed and the histopathological examination
confirmed the diagnosis of Grover?s disease. After the systemic treatment
using corticosteroids and antihistamines, with gradual dose reduction and
application of topical corticosteroids and emollients, complete regression
of the skin lesions was achieved. Conclusion. Since the clinical
manifestations of the disease may be nonspecific and discrete,
dermatopathological analysis is of crucial importance in making the correct
diagnosis. In patients with atopy, the treatment with systemic
corticosteroids, antihistamines and topical agents may lead to regression of
skin lesions with a significant improvement in the quality of life.
Grover’s disease in a patient with atopic dermatitis - a case report