Benefits and safety of photodynamic therapy in patients with hilar cholangiocarcinoma: a meta-analysis

2022 ◽  
pp. 102712
Author(s):  
Pengcheng Chen ◽  
Ting Yang ◽  
Peidong Shi ◽  
Jiangbo Shen ◽  
Qingchun Feng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hilar Cholangiocarcinoma ◽  
Meta Analysis

scholarly journals Systematic Review and Meta-Analysis of In Vitro Anti-Human Cancer Experiments Investigating the Use of 5-Aminolevulinic Acid (5-ALA) for Photodynamic Therapy

2021 ◽  
Vol 14 (3) ◽  
pp. 229
Author(s):  
Yo Shinoda ◽  
Daitetsu Kato ◽  
Ryosuke Ando ◽  
Hikaru Endo ◽  
Tsutomu Takahashi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Human Cancer ◽  
Meta Analysis ◽  
Protoporphyrin Ix ◽  
Cell Types ◽  
Amino Acid Derivative ◽  
Photodynamic Diagnosis

5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These clinical applications are potentially based on in vitro cell culture experiments. Thus, conducting a systematic review and meta-analysis of in vitro 5-ALA PDT experiments is meaningful and may provide opportunities to consider future perspectives in this field. We conducted a systematic literature search in PubMed to summarize the in vitro 5-ALA PDT experiments and calculated the effectiveness of 5-ALA PDT for several cancer cell types. In total, 412 articles were identified, and 77 were extracted based on our inclusion criteria. The calculated effectiveness of 5-ALA PDT was statistically analyzed, which revealed a tendency of cancer-classification-dependent sensitivity to 5-ALA PDT, and stomach cancer was significantly more sensitive to 5-ALA PDT compared with cancers of different origins. Based on our analysis, we suggest a standardized in vitro experimental protocol for 5-ALA PDT.

Photodynamic therapy in the treatment of chronic periodontitis: a systematic review and meta-analysis

2011 ◽  
Vol 28 (2) ◽  
pp. 669-682 ◽  
Author(s):  
Fabrizio Sgolastra ◽  
Ambra Petrucci ◽  
Roberto Gatto ◽  
Giuseppe Marzo ◽  
Annalisa Monaco
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Chronic Periodontitis ◽  
Meta Analysis

Phase II study of photodynamic therapy and metal stent as palliative treatment for nonresectable hilar cholangiocarcinoma

2003 ◽  
Vol 57 (7) ◽  
pp. 860-867 ◽  
Author(s):  
Franz Ludwig Dumoulin ◽  
Thomas Gerhardt ◽  
Sybille Fuchs ◽  
Christian Scheurlen ◽  
Michael Neubrand ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Phase Ii ◽  
Hilar Cholangiocarcinoma ◽  
Palliative Treatment ◽  
Phase Ii Study ◽  
Metal Stent

scholarly journals Efficacy evaluation of photodynamic therapy for oral lichen planus: a systematic review and meta-analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuqing He ◽  
Jiaxin Deng ◽  
Yi Zhao ◽  
Huiqian Tao ◽  
Hongxia Dan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Diode Laser ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Lesion Size ◽  
Cochrane Library ◽  
Oral Lichen

Abstract Background Photodynamic therapy (PDT) is a new option for oral lichen planus (OLP) management; however, there are different opinions on the efficacy of PDT for OLP. The aim of this study was to comprehensively assess the efficacy of PDT in the treatment of OLP and compare PDT with steroid therapy. Methods A systematic review and meta-analysis were conducted to assess the curative effect of PDT. Five electronic databases were searched, PubMed, Web of Science, the Cochrane Library, Embase, and EBSCO up to 1 December, 2019. Random and fixed effects models for pooled estimates calculation were used and the Meta package of R was applied. Results Pooled estimates revealed that, after PDT, the lesion size decreased by 1.53 cm2 (95% confidence interval (CI): 0.71–2.35) after PDT and the partial response (PR) was 0.77 (95% CI: 0.65–0.85). The visual analogue scale (VAS) score decreased by 3.82 (95% CI: 2.80–4.85) and the Thongprasom sign score decreased by 1.33 (95% CI: 0.56–2.10) after PDT. Subgroup analyses revealed that the 5-aminolevulinic acid (5-ALA) was more effective than methylene blue (MB), with a PR of 0.87 (95% CI: 0.80–0.91). The topical use of 5-ALA yielded a better response than gargling methylene blue. In terms of VAS, the diode laser showed a better clinical PR in the treatment of OLP. In terms of changes in lesion size, the efficacy of the semiconductor laser was higher than that of the diode laser. PDT had a similar efficacy to topical corticosteroids, as shown by pooled estimates of five randomised controlled trials with 139 lesions. Conclusion This systematic review indicates that PDT is an effective treatment modality for the management of OLP. PDT is as effective as topical corticosteroid in the treatment of OLP and could be used for cases resistant to steroids or when steroids are contraindicated.

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