Viral-Mediated Gene Replacement Therapy in the Developing Central Nervous System: Current Status and Future Directions

2020 ◽  
Vol 110 ◽  
pp. 5-19
Author(s):  
Julie Uchitel ◽  
Boris Kantor ◽  
Edward C. Smith ◽  
Mohamad A. Mikati
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Replacement Therapy ◽  
Gene Replacement ◽  
Current Status ◽  
Future Directions ◽  
Gene Replacement Therapy

scholarly journals Bioanalysis of small-molecule drugs in nasal and paranasal tissues and secretions: Current status and perspectives

2012 ◽  
Vol 10 (3) ◽  
pp. 686-702
Author(s):  
Ana Serralheiro ◽  
Gilberto Alves ◽  
Amílcar Falcão
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Small Molecule ◽  
Intranasal Administration ◽  
Quantitative Measurement ◽  
Current Status ◽  
Small Molecule Drugs ◽  
Development And Validation ◽  
Liquid Chromatographic

AbstractOver the last years, interest in intranasal administration as an alternative and promising route for the delivery of drugs withlocal, systemic, and even central nervous system action has tremendously increased. Accordingly, understanding of the propertiesand characteristics of the nasal cavity as well as the biodisposition processes of drugs into the nasal compartments is acquiringa significant prominence in the field of pharmacology. In this context, the development and validation of bioanalytical methodologies for the quantitative measurement of drugs and their metabolites in nasal and paranasal tissues and/or secretions is of the utmostimportance. However, currently, information concerning bioanalysis of drugs in nasal and paranasal tissues and/or secretionsis scattered. This review aims to provide a valuable overview of the methodologies that have been used for the collectionand preparation of nasal and paranasal samples with special emphasis placed on the review of liquid chromatographic methodsemployed for the quantitative determination of small-molecule drugs and their metabolites in such specimens.

scholarly journals An overview of travel-associated central nervous system infectious diseases: risk assessment, general considerations and future directions

2014 ◽  
Vol 4 (8) ◽  
pp. 589-596
Author(s):  
Morteza Izadi ◽  
Arman Is'haqi ◽  
Mohammad Ali Is'haqi ◽  
Nematollah Jonaidi Jafari ◽  
Fatemeh Rahamaty ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Central Nervous System ◽  
Nervous System ◽  
Infectious Diseases ◽  
Future Directions

scholarly journals MEN1 Gene Replacement Therapy Reduces Proliferation Rates in a Mouse Model of Pituitary Adenomas

2012 ◽  
Vol 72 (19) ◽  
pp. 5060-5068 ◽  
Author(s):  
Gerard V. Walls ◽  
Manuel C. Lemos ◽  
Mahsa Javid ◽  
Miriam Bazan-Peregrino ◽  
Jeshmi Jeyabalan ◽  
...  
Keyword(s):  
Mouse Model ◽  
Replacement Therapy ◽  
Pituitary Adenomas ◽  
Gene Replacement ◽  
Men1 Gene ◽  
Gene Replacement Therapy

Delivery of cytosolic liver arginase into the mitochondrial matrix space: A possible novel site for gene replacement therapy

1996 ◽  
Vol 22 (6) ◽  
pp. 489-498 ◽  
Author(s):  
Paul B. Wissmann ◽  
Barbara K. Goodman ◽  
Joseph G. Vockley ◽  
Rita M. Kern ◽  
Stephen D. Cederbaum ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Gene Replacement ◽  
Mitochondrial Matrix ◽  
Matrix Space ◽  
Gene Replacement Therapy
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