Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors

Peptides ◽  
2006 ◽  
Vol 27 (1) ◽  
pp. 178-182 ◽  
Author(s):  
Kazuhiro Takahashi ◽  
Kazuhito Totsune ◽  
Masayuki Saruta ◽  
Tsuyoshi Fukuda ◽  
Takashi Suzuki ◽  
...  
Keyword(s):  
Adrenal Glands ◽  
Adrenal Tumors ◽  
Urocortin 3

scholarly journals Morphology of focal adrenal lesions in patients with adrenal hypertension

2018 ◽  
Vol 24 (4) ◽  
pp. 441-447
Author(s):  
V. G. Chobitko ◽  
O. V. Maksimova ◽  
M. M. Orlova ◽  
A. V. Frolova ◽  
A. M. Napsheva
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Morphological Study ◽  
Adrenal Glands ◽  
Exclusion Criterion ◽  
Adrenal Tumors ◽  
Blood Pressure Elevation ◽  
Asymptomatic Pheochromocytoma ◽  
Design And Methods ◽  
Adrenal Hypertension

Objective. To evaluate the morphologу of focal formations of the adrenal glands after adrenalectomy.Design and methods. We analyzed the adrenal glands of 44 patients who underwent the surgery in the Research Institute of Fundamental and Clinical Urinephrology of Saratov in 2004–2016. Renovascular hypertension was the exclusion criterion.Results. The majority of the examined patients (72,7 %) had adrenal hypertension, caused by hormonally active adrenal tumors: pheochromocytoma, corticosteroma and aldosterome. Hormonally inactive tumors were found in 12,5 % patients with adrenal hypertension. Therefore, essential hypertension was diagnosed in these cases. In total 27,3 % patients underwent resection of the incidentalomas, among them 16,7 % were diagnosed as “silent” chromaffin tumors which do not lead to the blood pressure elevation.Conclusions. In the majority of cases (87,5 %), patients who undergo surgery due to adrenal focal formation demonstrate adrenal hypertension related to a hormonally active tumor. Adrenal hypertension is more often diagnosed in middle-aged women, who show higher blood pressure, smaller adrenal glands compared to those who have hormonally inactive adenomas. Based on the morphological study, asymptomatic pheochromocytoma was diagnosed in 16,7 % cases.

Disorders of the Adrenal Glands

2017 ◽  
Author(s):  
Carolina Martinez ◽  
Kelvin Memeh ◽  
Beatrice Caballero ◽  
Marlon A Guerrero
Keyword(s):  
Key Words ◽  
Adrenal Glands ◽  
Cushing Syndrome ◽  
Malignant Potential ◽  
Malignant Pheochromocytoma ◽  
Adrenal Tumors ◽  
Anatomy And Physiology ◽  
Adrenal Hormone ◽  
Addison Disease ◽  
Conn Syndrome

Adrenal tumors are most commonly identified incidentally during imaging for nonadrenal causes. Others may be identified after a patient presents with symptoms of adrenal hormone excess. Adrenal tumors are categorized as functional or nonfunctional, as well as by their malignant potential. It is important to understand the functionality of adrenal glands and properly diagnose potentially hormonally active adrenal tumors. This review outlines the anatomy and physiology of the adrenal glands and details the management of the diseases that result from adrenal hormone excess. This review contains 8 figures, 7 tables, and 27 references. Key words: Addison disease, adrenal, aldosterone, catecholamine, Conn syndrome, cortisol, Cushing syndrome, function, glucocorticoid, malignant, pheochromocytoma 

Diseases of the Adrenal Glands: Radiologic Diagnosis

PEDIATRICS ◽  
1964 ◽  
Vol 33 (2) ◽  
pp. 317-317
Author(s):  
FREDERIC N. SILVERMAN
Keyword(s):  
Adrenal Mass ◽  
Adrenal Glands ◽  
Adrenal Tumors ◽  
Radiologic Diagnosis ◽  
Clinical Syndromes ◽  
Mass Lesions ◽  
Retroperitoneal Air

The author presents a succinct view of diseases of the adrenal glands in which radiologic diagnosis, especially with presacral retroperitoneal air injections is an important consideration There are 15 brief chapters well illustrated and effectively documented (324 items are listed in the bibliography) of which 10 are devoted to individual adrenal mass lesions. The first 5 chapters include a classification of adrenal tumors and survey of clinical syndromes comments on conventional radiographic techniques and the technique of presacral retroperitoneal pneumography, and a consideration of adrenal calcifications and normal radiographic anatomy.

Ultrasonographic characteristics of both adrenal glands in 15 dogs with functional adrenocortical tumors

1999 ◽  
Vol 35 (3) ◽  
pp. 193-199 ◽  
Author(s):  
A Hoerauf ◽  
C Reusch
Keyword(s):  
Adrenal Gland ◽  
Adrenal Glands ◽  
Adrenal Tumors ◽  
Ultrasonographic Examination ◽  
Adrenocortical Tumors ◽  
Normal Shape ◽  
Bilateral Adrenal Tumors ◽  
Gland Enlargement

Ultrasonographic examination of both adrenal glands was performed in 15 dogs with functional adrenocortical tumors (FAT). Bilateral adrenal tumors were diagnosed in three of 15 dogs, and unilateral tumors were diagnosed in 12 of 15 dogs. Adrenal tumors were characterized by adrenal gland enlargement with loss of the normal shape and parenchymal structure. The contralateral adrenal gland could be imaged in all dogs with unilateral tumors. Based on size, shape, and parenchymal structure, the contralateral adrenal gland was similar to adrenal glands of normal dogs. The results of this study show that: 1) both adrenal glands should be imaged routinely in dogs with hyperadrenocorticism; 2) bilateral adrenocortical tumors seem to be more frequent than previously assumed; 3) one normal adrenal gland does not exclude the existence of a contralateral FAT; and 4) the functional atrophy of the contralateral adrenal gland in dogs with FAT may not be apparent ultrasonographically.

Immunoreactive brain natriuretic peptide in human adrenal glands and adrenal tumors

1996 ◽  
Vol 135 (3) ◽  
pp. 352-356 ◽  
Author(s):  
Kazuhito Totsune ◽  
Kazuhiro Takahashi ◽  
Osamu Murakami ◽  
Fumitoshi Satoh ◽  
Masahiko Sone ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Column Chromatography ◽  
High Performance ◽  
Adrenal Glands ◽  
Molecular Forms ◽  
Adrenal Tumors ◽  
Adrenocortical Adenomas ◽  
Applied Physiology ◽  
Normal Human

Totsune K, Takahashi K, Murakami O, Satoh F, Sone M, Ohneda M. Miura Y. Mouri T. Immunoreactive brain natriuretic peptide in human adrenal glands and adrenal tumors. Eur J Endocrinol 1996;135:352–6. ISSN 0804–4643 The presence of brain natriuretic peptide (BNP) in tissues of human adrenal glands and adrenal tumors was investigated by radioimmunoassay. Immunoreactive BNP concentrations were 0.203 ± 0.061 pmol/g wet tissue (mean ± sem) in normal parts of adrenal glands (cortex and medulla. N = 8), 0.205 ± 0.037 pmol/g wet tissue in pheochromocytomas (N = 8), 0.230 ± 0.062 pmol/g wet tissue in aldosteronomas (N = 11) and 0.180 ± 0.054 pmol/g wet tissue in adrenocortical adenomas with Cushing's syndrome (N = 4). Sephadex G-50 superfine column chromatography and reverse-phase high-performance liquid chromatography showed that most (> 70%) of the immunoreactive BNP in the normal part of adrenal glands was eluted in the position of human BNP-32. Sephadex G-50 superfine column chromatography of immunoreactive BNP in the pheochromocytoma and aldosteronoma showed four peaks: one in the position ofγ-BNP, one in the position of BNP-32, one between γ-BNP and BNP-32 and one in the smaller molecular weight region. The present study has shown that immunoreactive BNP is present both in normal human adrenal glands and in adrenal tumors. Multiple molecular forms of BNP were found to be present in the tumor tissues of pheochromocytoma and aldosteronoma. Kazuhiro Takahashi. Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, 2–1 Seiryo-machi, Aoba-ku. Sendai 980–77, Japan

Expression of stanniocalcin in zona glomerulosa and medulla of normal human adrenal glands, and some adrenal tumors and cell linesNote

Apmis ◽  
2000 ◽  
Vol 108 (5) ◽  
pp. 367-372 ◽  
Author(s):  
WAKAKO MIURA ◽  
KAZUTOSHI MIZUNASHI ◽  
NORIKO KIMURA ◽  
YOSHIO KOIDE ◽  
TAKAO NOSHIRO ◽  
...  
Keyword(s):  
Adrenal Glands ◽  
Zona Glomerulosa ◽  
Adrenal Tumors ◽  
Normal Human

scholarly journals Metastatic adrenal lesions in cancer patients.

2018 ◽  
Vol 11 (3) ◽  
pp. 179-182
Author(s):  
Ivan Petrovich Moshurov ◽  
Olga Valerievna Andreeva
Keyword(s):  
Cancer Patients ◽  
Adrenal Glands ◽  
Malignant Neoplasm ◽  
Needle Aspiration ◽  
Adrenal Tumors ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Fine Needle ◽  
History Of

Relevance.The col lective concept of" incidence " of the adrenal glands includes a group of neoplasms of more than 1 cm in diameter, accidentally revealed by radiation methods of research. With the development of methods of instrumental diagnostics, the number of adrenal glands detected by the incident is steadily increasing, including in patients with a history of malignant neoplasm (ZNO). Objective.Study of the frequency of occurrence metastaties  of adrenal tumors in cancer patients. Materials and methods. Made 137 fine-needle aspiration biopsies (TAB) of adrenal tumors in the patients in whom during follow-up were detected adrenal incidence. Results. According to the results of morphological verification in 44(32%) cases of adrenal tumors were metastatic. Conclusion. Adrenal tumors, detected in patients with malignant neoplasms of different localization, can be provided as metastatic and benign tumors. However, each revealed a tumor in the adrenal glands of patients undergoing treatment after testing shall be considered as potentially metastatic.

Disorders of the Adrenal Glands

2017 ◽  
Author(s):  
Carolina Martinez ◽  
Kelvin Memeh ◽  
Beatrice Caballero ◽  
Marlon A Guerrero
Keyword(s):  
Key Words ◽  
Adrenal Glands ◽  
Cushing Syndrome ◽  
Malignant Potential ◽  
Malignant Pheochromocytoma ◽  
Adrenal Tumors ◽  
Anatomy And Physiology ◽  
Adrenal Hormone ◽  
Addison Disease ◽  
Conn Syndrome

Adrenal tumors are most commonly identified incidentally during imaging for nonadrenal causes. Others may be identified after a patient presents with symptoms of adrenal hormone excess. Adrenal tumors are categorized as functional or nonfunctional, as well as by their malignant potential. It is important to understand the functionality of adrenal glands and properly diagnose potentially hormonally active adrenal tumors. This review outlines the anatomy and physiology of the adrenal glands and details the management of the diseases that result from adrenal hormone excess. This review contains 8 figures, 7 tables, and 27 references. Key words: Addison disease, adrenal, aldosterone, catecholamine, Conn syndrome, cortisol, Cushing syndrome, function, glucocorticoid, malignant, pheochromocytoma 

Autogenous transplants of adrenal fragments in an animal model.

2018 ◽  
Vol 90 (4) ◽  
pp. 23-28 ◽  
Author(s):  
Agnieszka Dworzyńska ◽  
Katarzyna Paduszyńska ◽  
Lech Pomorski
Keyword(s):  
Adrenal Gland ◽  
Adrenal Insufficiency ◽  
Adrenal Glands ◽  
Bilateral Adrenalectomy ◽  
Adrenal Tumors ◽  
Human Beings ◽  
Sprague Dawley ◽  
The Third ◽  
Sprague Dawley Rats ◽  
New Treatment

Introduction Adrenal insufficiency is a typical complication after surgical treatment of adrenal tumors, especially after the removal of both adrenal glands. Human beings are not able to survive without adrenal glands and without proper hormonal substitution. Autotransplantation of a fragment of the adrenal gland may prevent this complication. This can be done by transplanting the entire adrenal glands or its fragment, such as the adrenal cortex cells. In the case of adrenal tumors, the entire adrenal gland can not be transplanted. However, it is possible to transplant cells from the tumor-free part. Succesful adrenal autografts may result in a new treatment of adrenal insufficiency. Materials and Methods: Autograft transplantation was performed on 3 groups of Sprague Dawley rats. In the first group, physiological corticosterone concentrations were determined. These animals were not operated. In the second group, both adrenal glands were removed. Corticosterone concentrations were determined after bilateral adrenalectomy. The third group was divided into two parts. In the first subgroup, bilateral adrenalectomy was performed simultaneosly with adrenal transplant into the omentum. In the second subgroup, right adrenalectomy was performed simultaneosly with and adrenal transplant into the omentum followed a month later by left adrenalectomy. During the experiment, corticosterone concentrations were measured at 4 time points. Results. The statistical difference between corticosterone concentrations in rats after two timed adrenalectomies and rats after bilateral adrenalectomy was statistically different, but these results were far from physiological concentrations.

scholarly journals Angiomyolipoma and Malignant PEComa: Discussion of Two Rare Adrenal Tumors

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Douglas Kwazneski II ◽  
Megan Merrill ◽  
Jessica Young ◽  
Harry Sell
Keyword(s):  
Adrenal Glands ◽  
Case Reports ◽  
Adrenal Tumors ◽  
Complete Case ◽  
Rare Tumors ◽  
Frequent Site ◽  
The Subject ◽  
Microscopic Pathology ◽  
Pathology Samples

Angiomyolipoma and PEComa are rare tumors descending from perivascular epithelial cells (PECs), with distinctive IHC, morphological, and ultrastructural features. The kidney is the most frequent site of origin, but not the only one; however, adrenal gland angiomyolipomas are extremely rare. We describe two cases being found in the adrenal glands. Given the paucity of literature on the subject, more information on this disease is necessary for diagnosis and treatment. Here, we describe two complete case reports, from presentation to treatment and follow-up, along with imaging and microscopic pathology samples, and provide a comprehensive review as to the history and current literature available regarding these extremely rare tumors.

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