scholarly journals Morphology of focal adrenal lesions in patients with adrenal hypertension

2018 ◽  
Vol 24 (4) ◽  
pp. 441-447
Author(s):  
V. G. Chobitko ◽  
O. V. Maksimova ◽  
M. M. Orlova ◽  
A. V. Frolova ◽  
A. M. Napsheva
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Morphological Study ◽  
Adrenal Glands ◽  
Exclusion Criterion ◽  
Adrenal Tumors ◽  
Blood Pressure Elevation ◽  
Asymptomatic Pheochromocytoma ◽  
Design And Methods ◽  
Adrenal Hypertension

Objective. To evaluate the morphologу of focal formations of the adrenal glands after adrenalectomy.Design and methods. We analyzed the adrenal glands of 44 patients who underwent the surgery in the Research Institute of Fundamental and Clinical Urinephrology of Saratov in 2004–2016. Renovascular hypertension was the exclusion criterion.Results. The majority of the examined patients (72,7 %) had adrenal hypertension, caused by hormonally active adrenal tumors: pheochromocytoma, corticosteroma and aldosterome. Hormonally inactive tumors were found in 12,5 % patients with adrenal hypertension. Therefore, essential hypertension was diagnosed in these cases. In total 27,3 % patients underwent resection of the incidentalomas, among them 16,7 % were diagnosed as “silent” chromaffin tumors which do not lead to the blood pressure elevation.Conclusions. In the majority of cases (87,5 %), patients who undergo surgery due to adrenal focal formation demonstrate adrenal hypertension related to a hormonally active tumor. Adrenal hypertension is more often diagnosed in middle-aged women, who show higher blood pressure, smaller adrenal glands compared to those who have hormonally inactive adenomas. Based on the morphological study, asymptomatic pheochromocytoma was diagnosed in 16,7 % cases.

scholarly journals Risk factors and AGTR1 gene polymorphism (1166A>C) in patients with essential hypertension

2020 ◽  
Vol 24 (4 (96)) ◽  
pp. 99-104
Author(s):  
M. Semianiv
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Essential Hypertension ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
Control Group ◽  
Blood Pressure Elevation ◽  
A1166c Polymorphism ◽  
Gender And Age

Objective – to analyze the association of risk factors with the 1666 A>C polymorphism of the AGTR1 gene in patients with essential hypertension.Material and methods. 100 patients were screened, 72 of whom were genotyped. The control group consisted of 48 healthy individuals who did not differ in gender and age, and with the group of patients.Results. The obtained data confirmed that the level of blood pressure elevation is associated, to some extent, with modified (diabetes mellitus 2, smoking, body mass index) and unmodified factors (family history, gender) the risk of essential hypertension. The results of the analysis of blood pressure levels considering the A1166C polymorphism of the AGTR1 gene showed that the values of systolic and diastolic blood pressure in the group of patients with C-allele carriers were higher than in carriers of AA genotype: SBP – by 5.38% (p<0.05), DBP – by 5.15% (p<0.05). Conclusions. The level of blood pressure in patients with essential hypertension depends on body mass index and smoking. In carriers of the C-allele of the AGTR1 gene (A1166C), the level of systolic and diastolic blood pressure exceeds the ones of the carriers of the AA genotype. The presence of the C-allele of the AGTR1 gene (A1166C) almost doubles the risk of severe essential hypertension [OR = 2.75; p = 0.037].

Factors Participating in Blood Pressure Elevation After Discharge From the Hospital in Patients With Essential Hypertension

1990 ◽  
Vol 3 (5 Pt 1) ◽  
pp. 397-399
Author(s):  
Y. Hirata ◽  
T. Koide ◽  
S. Murao ◽  
H. Matsuoka ◽  
M. Ishii ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Elevation ◽  
Pressure Elevation

scholarly journals Analysis of gene-gene interactions of polymorphic cytokine genes loci in patients with essential hypertension

2012 ◽  
Vol 18 (5) ◽  
pp. 443-448
Author(s):  
Y. R. Timasheva ◽  
T. R. Nasibullin ◽  
I. A. Tuktarova ◽  
I. M. Karamova ◽  
A. N. Petrin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Essential Hypertension ◽  
Cardiovascular Diseases ◽  
Genetic Markers ◽  
Gene Interactions ◽  
Polymorphic Markers ◽  
Blood Pressure Elevation ◽  
Final Model ◽  
Key Factor

Background. Chronic systemic inflammation is a key factor in the pathogenesis of cardiovascular diseases. The exact mechanisms underlying blood pressure elevation are unclear, but recent findings suggest that inflammatory mediators are involved. The objective of our study was to investigate the influence of gene-gene interactions between IL6, IL1B, IL12B, TNF, LTA and IL10 genes polymorphic markers on susceptibility to essential hypertension. Results. In the ethnic group of Tatars residing in Bashkortostan, Russia, we found an association of IL1B rs16944 and IL10 rs1800872 polymorphic markers with the disease. The analysis of gene-gene interactions showed significant synergy between IL12B rs3212227 and TNF rs1800629 polymorphic markers towards essential hypertension. The final model (logistic regression) included IL10 rs1800872 genetic marker and the combination of IL12B rs3212227 and TNF rs1800629 genetic markers as optimal predictors of essential hypertension. Conclusion. Our data confirm the involvement of cytokine system in the development of essential hypertension.

scholarly journals IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION

2019 ◽  
Vol 21 (3) ◽  
pp. 407-418 ◽  
Author(s):  
Ya. R. Timasheva
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Immune Cells ◽  
Vascular Remodeling ◽  
Modern Concept ◽  
Systemic Hypertension ◽  
Active Forms Of Oxygen ◽  
Blood Pressure Elevation ◽  
Perivascular Adipose Tissue ◽  
Pressure Elevation

According to modern concept of the etiopathogenesis of essential hypertension, immune cells play an important role in its development. Mediators produced by immunocompetent cells participate in the initiation and maintenance of chronic systemic inflammation and promote the development of vascular remodeling which is an important part of the pathogenesis of the disease and target organ damage. The immune mechanisms underlying blood pressure elevation include the activation of innate and adaptive immune cells. Endothelial damage triggers an inflammatory cascade, causing migration of the immune cells to the inflammatory site, mediated by chemokines and adhesion molecules. Macrophage infiltration of perivascular tissue contributes to impaired vasodilation and damage to target organs due to the production of active forms of oxygen. Angiotensin II also causes T cell infiltration of perivascular adipose tissue and adventitia and an increased production of tumor necrosis factor alpha and interferon gamma. In addition, T lymphocytes express the mineralocorticoid receptor involved in the development of systemic hypertension. An important role in the progression of hypertension belongs to interleukin-17, which is involved in blood pressure elevation and vascular remodeling. The review also contains data on the effect of gut microbiota on the regulation of blood pressure and the development of hypertension.

scholarly journals Arterial hypertension in the view of a patient

2012 ◽  
Vol 18 (6) ◽  
pp. 569-576
Author(s):  
V. P. Sergeev
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Management Approach ◽  
Analysis Model ◽  
Blood Pressure Elevation ◽  
Pressure Dynamics ◽  
Definition Of ◽  
Model Formation ◽  
Design And Methods ◽  
Working Hypotheses

Background. At the present time there are no objective methods that enable definition of the mechanisms of blood pressure elevation in a particular patient. Objective. Based on the results of blood pressure and heart rate measures to find new additional features that could help a differentiated management approach. Design and methods. Literature analysis, model formation and analysis, statistical analysis were performed. Results. The new criteria based on the measurements of blood pressure and heart rate are offered. A new way of reporting the results of blood pressure measurements, and a new computer program for analyses observations with the probability characteristics are offered. Conclusions. The present result can be used for the assessment of blood pressure dynamics, and for check-up of the working hypotheses.

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