scholarly journals Delivered dose quantification in prostate radiotherapy using online 3D cine imaging and treatment log files on a combined 1.5T magnetic resonance imaging and linear accelerator system

2020 ◽  
Vol 15 ◽  
pp. 23-29 ◽  
Author(s):  
Charis Kontaxis ◽  
Daan M. de Muinck Keizer ◽  
Linda G.W. Kerkmeijer ◽  
Thomas Willigenburg ◽  
Mariska D. den Hartogh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Linear Accelerator ◽  
Cine Imaging ◽  
Resonance Imaging ◽  
Prostate Radiotherapy ◽  
Log Files ◽  
Accelerator System ◽  
Delivered Dose

scholarly journals Planning feasibility of extremely hypofractionated prostate radiotherapy on a 1.5 T magnetic resonance imaging guided linear accelerator

2019 ◽  
Vol 11 ◽  
pp. 16-20 ◽  
Author(s):  
Mariska D. den Hartogh ◽  
Hans C.J. de Boer ◽  
Eline N. de Groot-van Breugel ◽  
Jochem R.N. van der Voort van Zyp ◽  
Jochem Hes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Linear Accelerator ◽  
Resonance Imaging ◽  
Prostate Radiotherapy

scholarly journals Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of MINOCA in Women

Circulation ◽  
2020 ◽  
Author(s):  
Harmony R. Reynolds ◽  
Akiko Maehara ◽  
Raymond Y. Kwong ◽  
Tara Sedlak ◽  
Jacqueline Saw ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optical Coherence Tomography ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cardiac Magnetic Resonance Imaging ◽  
Plaque Rupture ◽  
Cine Imaging ◽  
Optical Coherence ◽  
Resonance Imaging ◽  
Imaging Results

Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in 6-15% of MI and disproportionately affects women. Scientific statements recommend multi-modality imaging in MINOCA to define the underlying cause. We performed coronary optical coherence tomography (OCT) and cardiac magnetic resonance imaging (CMR) to assess mechanisms of MINOCA. Methods: In this prospective, multicenter, international, observational study, we enrolled women with a clinical diagnosis of MI. If invasive coronary angiography revealed <50% stenosis in all major arteries, multi-vessel OCT was performed, followed by CMR (cine imaging, late gadolinium enhancement, and T2-weighted imaging and/or T1 mapping). Angiography, OCT, and CMR were evaluated at blinded, independent core laboratories. Culprit lesions identified by OCT were classified as definite or possible. The CMR core laboratory identified ischemia-related and non-ischemic myocardial injury. Imaging results were combined to determine the mechanism of MINOCA, when possible. Results: Among 301 women enrolled at 16 sites, 170 were diagnosed with MINOCA, of whom 145 had adequate OCT image quality for analysis; 116 of these underwent CMR. A definite or possible culprit lesion was identified by OCT in 46.2% (67/145) of participants, most commonly plaque rupture, intra-plaque cavity or layered plaque. CMR was abnormal in 74.1% (86/116) of participants. An ischemic pattern of CMR abnormalities (infarction or myocardial edema in a coronary territory) was present in 53.4% of participants undergoing CMR (62/116). A non-ischemic pattern of CMR abnormalities (myocarditis, takotsubo syndrome or non-ischemic cardiomyopathy) was present in 20.7% (24/116). A cause of MINOCA was identified in 84.5% of the women with multi-modality imaging (98/116), higher than with OCT alone (p<0.001) or CMR alone (p=0.001). An ischemic etiology was identified in 63.8% of women with MINOCA (74/116), a non-ischemic etiology was identified in 20.7% (24/116), and no mechanism was identified in 15.5% (18/116). Conclusions: Multi-modality imaging with coronary OCT and CMR identified potential mechanisms in 84.5% of women with a diagnosis of MINOCA, three-quarters of which were ischemic and one-quarter of which were non-ischemic, alternate diagnoses to MI. Identification of the etiology of MINOCA is feasible and has the potential to guide medical therapy for secondary prevention. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT02905357

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