Interstitial lung disease induced by fluoxetine: Systematic review of literature and analysis of Vigiaccess, Eudravigilance and a national pharmacovigilance database

Several retrospectivee described the association of interstitial lung disease (ILD) and ANCA-associated vasculitis (AAV). However, the relationship between the ILD and mortality in AAV patients have not been established so far. This study aims to estimate the relevance of AAV-associated-ILD (AAV-ILD) and mortality risk by conducting a systematic review and meta-analysis.A comprehensive systematic review was conducted in accordance with the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses). PubMed, Embase.com and the Cochrane Library (Wiley) were searched for original observational studies. Summary estimates were derived with a random-effects model and reported as risk ratio (RR), tested for publication bias and heterogeneity. Ten retrospective cohort studies were included, comprising 526 AAV-ILD patients enrolled from 1974 to 2018. Meta-analysis yielded a pooled RR of 2.90 (95% confidence interval 1.77–4.74) for death among those with AAV-ILD compared to control group. UIP pattern was associated with an even poorer prognosis in comparison to non-UIP pattern (RR 4.36, 95% confidence interval 1.14–16.78). Sensitivity analysis suggested that the meta-RR result was not skewed by a single dominant study. ILD might be associated with a higher mortality risk in AAV patients.

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Correction to: The prevalence of obstructive sleep apnea in interstitial lung disease: a systematic review and meta-analysis

Sleep And Breathing ◽

10.1007/s11325-021-02354-8 ◽

2021 ◽

Author(s):

Yang Cheng ◽

Yan Wang ◽

Li Dai

Keyword(s):

Systematic Review ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Meta Analysis ◽

Obstructive Sleep

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Efficacy of mycophenolate mofetil versus cyclophosphamide in systemic sclerosis-related interstitial lung disease: a systematic review and meta-analysis

Clinical Rheumatology ◽

10.1007/s10067-021-05794-5 ◽

2021 ◽

Author(s):

Xinyu Ma ◽

Rui Tang ◽

Mei Luo ◽

Zhuotong Zeng ◽

Yaqian Shi ◽

...

Keyword(s):

Systematic Review ◽

Mycophenolate Mofetil ◽

Systemic Sclerosis ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Meta Analysis

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Interstitial pneumonia with autoimmune features and platypnea-orthopnea syndrome

BMJ Case Reports ◽

10.1136/bcr-2019-230948 ◽

2019 ◽

Vol 12 (9) ◽

pp. e230948

Author(s):

Uthara Mathew ◽

Ankit Mittal ◽

Surabhi Vyas ◽

Animesh Ray

Keyword(s):

Systematic Review ◽

Interstitial Lung Disease ◽

Connective Tissue ◽

Interstitial Pneumonia ◽

Immunosuppressive Treatment ◽

Usual Interstitial Pneumonia ◽

Lower Lobe ◽

Autoimmune Disorder ◽

Shortness Of Breath ◽

Review Of Literature

Interstitial pneumonia with autoimmune features (IPAF) is a recently proposed terminology for interstitial lung disease (ILD) with evidence of autoimmunity that does not meet the criteria for a defined connective tissue disease (CTD). Although ILD is well recognised in patients with established CTD, it is rarely the sole presenting feature of CTD. We report a case of 22-year-old male patient, who presented with progressive shortness of breath for 2 months and had features suggestive of platypnea-orthodeoxia syndrome (POS). Imaging revealed ILD with usual interstitial pneumonia pattern. Patient had features of autoimmune disorder but did not fulfil the criteria for any CTD and hence was labelled as IPAF. His POS was attributed predominantly to the lower lobe disease. The patient responded well to immunosuppressive treatment. A systematic review of literature of all cases with POS due to pulmonary parenchymal involvement has also been done.

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