Intrauterine growth restriction may reduce hepatic drug metabolism in the early neonatal period

2018 ◽  
Vol 134 ◽  
pp. 68-78 ◽  
Author(s):  
Jia Yin Soo ◽  
Michael D. Wiese ◽  
Mary J. Berry ◽  
I. Caroline McMillen ◽  
Janna L. Morrison
Keyword(s):  
Drug Metabolism ◽  
Intrauterine Growth Restriction ◽  
Neonatal Period ◽  
Growth Restriction ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
Intrauterine Growth ◽  
Early Neonatal Period

scholarly journals Some health aspects of children born with different types of intrauterine growth restriction during the early neonatal period

2017 ◽  
Vol 98 (1) ◽  
pp. 44-52 ◽  
Author(s):  
V V Derevtsov
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Restriction ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Growth Restriction ◽  
Past Medical History ◽  
Intrauterine Growth ◽  
Septal Defects ◽  
Early Neonatal Period ◽  
Different Types

Aim. To evaluate some health aspects of children born with different types of intrauterine growth restriction during the early neonatal period.Methods. Clinical and anamnestic, physical, laboratory, electrophysiological, ultrasound and statistical methods were used. Children’s past medical history, development during early neonatal period, physical development, functioning of autonomic nervous system and cardiovascular system were assessed.Results. It was revealed that development of different types of intrauterine growth restriction is related to father and mother’s age at the time of pregnancy, women’s body mass before pregnancy, and time of pregnancy complication development (abortion risk, pre-eclampsia, arterial hypertension, Rh-immunization, edema). Fetuses with asymmetric type of intrauterine growth retardation had survived hypoxia more often (by 4.87 times). Children with symmetrical type of intrauterine growth retardation were more often born by C-section (by 2.66 times), with smaller anthropometric measurements, with more frequent and severe hypotrophy, moderate and severe cerebral ischemia and mild intracranial hemorrhage, cryptorchidism, kidney diseases, atrial septal defects, muscular ventricular septal defects, open arterial duct, and depleted reserves. Children with asymmetric type of intrauterine growth retardation more often had hypoglycemia, jaundice, polycythemia, restricted adaptation reserves, myocardial metabolic disorders, anterior mitral valve leaflet prolapse, posthypoxic changes similar to hypertrophic cardiopathy.Conclusion. Revealed features of past medical history, development during early neonatal period of life, physical development, functioning of autonomic nervous system and cardiovascular system in different types of children’s intrauterine growth restriction can promote formulation of criteria for early diagnosis of adaptive and reserve disorders and identification of dispensary groups.

scholarly journals Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia

2019 ◽  
Vol 60 (5) ◽  
pp. 496-503 ◽  
Author(s):  
Hiroaki Kurata ◽  
Masayuki Ochiai ◽  
Hirosuke Inoue ◽  
Takeshi Kusuda ◽  
Junko Fujiyoshi ◽  
...  
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Intrauterine Growth Restriction ◽  
Neonatal Period ◽  
Growth Restriction ◽  
Intrauterine Growth

Structural Brain Changes during the Neonatal Period in a Rabbit Model of Intrauterine Growth Restriction

2020 ◽  
Vol 42 (5-6) ◽  
pp. 217-229
Author(s):  
Laura Pla ◽  
Miriam Illa ◽  
Carla Loreiro ◽  
Mari Carmen Lopez ◽  
Paula Vázquez-Aristizabal ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Neonatal Period ◽  
Rabbit Model ◽  
Functional Results ◽  
Growth Restriction ◽  
Functional Changes ◽  
Intrauterine Growth ◽  
Brain Changes ◽  
Neuronal Arborization ◽  
Structural Brain

Background: Intrauterine growth restriction (IUGR) is associated with abnormal neurodevelopment, but the associated structural brain changes are poorly documented. The aim of this study was to describe in an animal model the brain changes at the cellular level in the gray and white matter induced by IUGR during the neonatal period. Methods: The IUGR model was surgically induced in pregnant rabbits by ligating 40–50% of the uteroplacental vessels in 1 horn, whereas the uteroplacental vessels of the contralateral horn were not ligated. After 5 days, IUGR animals from the ligated horn and controls from the nonligated were delivered. On the day of delivery, perinatal data and placentas were collected. On postnatal day 1, functional changes were first evaluated, and thereafter, neuronal arborization in the frontal cortex and density of pre-oligodendrocytes, astrocytes, and microglia in the corpus callosum were evaluated. Results: Higher stillbirth in IUGR fetuses together with a reduced birth weight as compared to controls was evidenced. IUGR animals showed poorer functional results, an altered neuronal arborization pattern, and a decrease in the pre-oligodendrocytes, with no differences in microglia and astrocyte densities. Conclusions: Overall, in the rabbit model used, IUGR is related to functional and brain changes evidenced already at birth, including changes in the neuronal arborization and abnormal oligodendrocyte maturation.

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

Sign in / Sign up

Export Citation Format

Share Document