scholarly journals Some health aspects of children born with different types of intrauterine growth restriction during the early neonatal period

2017 ◽  
Vol 98 (1) ◽  
pp. 44-52 ◽  
Author(s):  
V V Derevtsov
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Restriction ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Growth Restriction ◽  
Past Medical History ◽  
Intrauterine Growth ◽  
Septal Defects ◽  
Early Neonatal Period ◽  
Different Types

Aim. To evaluate some health aspects of children born with different types of intrauterine growth restriction during the early neonatal period.Methods. Clinical and anamnestic, physical, laboratory, electrophysiological, ultrasound and statistical methods were used. Children’s past medical history, development during early neonatal period, physical development, functioning of autonomic nervous system and cardiovascular system were assessed.Results. It was revealed that development of different types of intrauterine growth restriction is related to father and mother’s age at the time of pregnancy, women’s body mass before pregnancy, and time of pregnancy complication development (abortion risk, pre-eclampsia, arterial hypertension, Rh-immunization, edema). Fetuses with asymmetric type of intrauterine growth retardation had survived hypoxia more often (by 4.87 times). Children with symmetrical type of intrauterine growth retardation were more often born by C-section (by 2.66 times), with smaller anthropometric measurements, with more frequent and severe hypotrophy, moderate and severe cerebral ischemia and mild intracranial hemorrhage, cryptorchidism, kidney diseases, atrial septal defects, muscular ventricular septal defects, open arterial duct, and depleted reserves. Children with asymmetric type of intrauterine growth retardation more often had hypoglycemia, jaundice, polycythemia, restricted adaptation reserves, myocardial metabolic disorders, anterior mitral valve leaflet prolapse, posthypoxic changes similar to hypertrophic cardiopathy.Conclusion. Revealed features of past medical history, development during early neonatal period of life, physical development, functioning of autonomic nervous system and cardiovascular system in different types of children’s intrauterine growth restriction can promote formulation of criteria for early diagnosis of adaptive and reserve disorders and identification of dispensary groups.

Intrauterine growth restriction may reduce hepatic drug metabolism in the early neonatal period

2018 ◽  
Vol 134 ◽  
pp. 68-78 ◽  
Author(s):  
Jia Yin Soo ◽  
Michael D. Wiese ◽  
Mary J. Berry ◽  
I. Caroline McMillen ◽  
Janna L. Morrison
Keyword(s):  
Drug Metabolism ◽  
Intrauterine Growth Restriction ◽  
Neonatal Period ◽  
Growth Restriction ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
Intrauterine Growth ◽  
Early Neonatal Period

scholarly journals Activity of the brain isoenzyme creatine kinase in newborns with intrauterine growth retardation

2003 ◽  
Vol 52 (4) ◽  
pp. 28-32
Author(s):  
D. S. Dodkhoev ◽  
I. I. Evsyukova ◽  
Z. N. Tumasova ◽  
А. V. Harutyunyan
Keyword(s):  
Creatine Kinase ◽  
Growth Retardation ◽  
Clinical Condition ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Placental Insufficiency ◽  
Intrauterine Growth ◽  
Early Neonatal Period ◽  
The Brain

The CK-BB activity in neonates with intrauterine growth retardation (IUGR) was investi-gated and the results were compared to their clinical condition in early neonatal period. The re-sults of the study have shown that the CK-BB activity was increased in neonates with symmetric IUGR and in the presence of chronic placental insufficiency of infectious genesis.

scholarly journals Neonatal hypoglycemia in children with risk factors

2022 ◽  
pp. 80-84
Author(s):  
E. V. Antsiferova ◽  
T. E. Taranushenko ◽  
N. G. Kiseleva ◽  
E. A. Belyaeva ◽  
T. I. Donskaya
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Blood Glucose ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Large Body ◽  
Neonatal Hypoglycemia ◽  
Intrauterine Growth ◽  
Early Neonatal Period

Objective: The analysis of clinical-laboratory peculiarities and the dynamics of glycemia clarifying the terms of blood glucose stabilization during the early neonatal period in children having risk factors of the development of such state.Methods: Open, retrospective , continuous, single-center study was conducted. It was aimed at getting preliminary data that is important for planning further tactics of examining newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation).The target group of the survey included 522 newborns of both genders in the early neonatal period (from 0 to 7 days of life).Results: There is data on the frequency of first indicated hypoglycemia in newborns having risk factors of the development of such state, clinicallaboratory peculiarities, the dynamics of glycemia during early neonatal period, and also the period of blood glucose stabilization (the age of reaching normoglycemia). Neonatal hypoglycemia was detected in 40.2% of examined children. Laboratory manifestation during the first day of life was noticed 62.9% of cases with the further normalization of glucose level in blood in 24 hours in 73.3% of newborns. Significant reduction of blood glucose was observed in 54.8% of cases requiring hypoglycemia therapy with parenteral prescription of 10% glucose solution. Hypoglycemia jugulated against oral correction of 5% glucoses solution in 40.5 % of cases. 4.8% of children got the level of glucose stabilized after introduction of supplementary feeding.Conclusion: The results of the newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation) examinations are presented. The peculiarities of neonatal hypoglycemia are: the absence of a typical clinical symptoms among 89% of children. Asymptomatic course of hypoglycemia confirms the importance and necessity of glycemia monitoring in the early neonatal period in order to conduct timely and adequate therapy.

Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction

2020 ◽  
Vol 11 (5) ◽  
pp. 4456-4470 ◽  
Author(s):  
Hao Zhang ◽  
Yi Ma ◽  
Mengzhi Wang ◽  
Mabrouk Elsabagh ◽  
Juan J. Loor ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Barrier Function ◽  
Intrauterine Growth Restriction ◽  
Intrauterine Growth Retardation ◽  
Dietary Supplementation ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Mitochondrial Functions ◽  
And Mitochondrial Functions

The work aimed at investigating the effects of N-carbamylglutamate (NCG) or l-arginine (Arg) supplementation on the duodenal mitophagy, inflammation, and barrier function in suckling lambs suffering from intrauterine-growth-retardation (IUGR).

Categories of intrauterine growth retardation

1993 ◽  
Vol 5 (4) ◽  
pp. 203-212 ◽  
Author(s):  
Roger A Fay ◽  
David A Ellwood
Keyword(s):  
Soft Tissue ◽  
Fetal Growth ◽  
Gestational Age ◽  
Growth Retardation ◽  
Large Scale ◽  
Intrauterine Growth Retardation ◽  
Low Birthweight ◽  
Ponderal Index ◽  
Intrauterine Growth ◽  
Different Types

Originally all low birthweight infants were considered to be premature. When prematurity was redefined in terms of gestational age (SGA) and not preterm. With the large scale collection of obstetric data the distributions of birthweight at different gestational ages were described and from these, infants who were SGA could be defined. SGA became synonymous with terms such as growth retardation, but it soon became appearent that the two were not necessarily interchangeable. Scott and Usher found that it was the degree of soft tissue wasting rather than birthweight that related to poor perinatal outcome. Miller and Hassanein stated that: “birthweight by itself is not a valid measure of fetal growth impairment”. They used Rorher’s Ponderal Index (weight (g) × 100/length (cm)) to diagnose the malnourished or excessively wasted infants with reduced soft tissue mass. Most studies of intrauterine growth retardation (IUGR) still use low birthweight for gestational age centile as their only definition of IUGR or only study infants who have a low birthweight. Altman and Hytten expressed disquiet about this definition and stated: “There is now an urgent need to establish true measures of fetal growth from which deviations indicating genuine growth retardation can be derived” and that “it is particularly important that some reliable measures of outcome should be established”. In large series of term deliveries published recently, two groups of IUGR infants with different growth patterens have been identified. These studies confirm that birthweight alone is inadequate to define the different types of IUGR. They established that low Ponderal Index (PI) is a measure of IUGR associated with an increased incidence of perinatal problems and that it is time to re-evaluate IUGR in terms of the different types of aberrant fetal growth.

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