Prolonged heart rate recovery time after 6-minute walk test is an independent risk factor for cardiac events in heart failure: a prospective cohort study

Physiotherapy ◽  
2021 ◽  
Author(s):  
G.N. Andrade ◽  
T. Rodrigues ◽  
J.Y. Takada ◽  
L.M. Braga ◽  
I.I.K. Umeda ◽  
...  
Author(s):  
Sabrina Lindemberg ◽  
Sergio Chermont ◽  
Mônica Quintão ◽  
Milena Derossi ◽  
Sergio Guilhon ◽  
...  

1997 ◽  
Vol 6 (5) ◽  
pp. 348-354 ◽  
Author(s):  
MA Woo ◽  
DK Moser ◽  
LW Stevenson ◽  
WG Stevenson

BACKGROUND: The 6-minute walk and heart rate variability have been used to assess mortality risk in patients with heart failure, but their relationship to each other and their usefulness for predicting mortality at 1 year are unknown. OBJECTIVE: To assess the relationships between the 6-minute walk test, heart rate variability, and 1-year mortality. METHOD: A sample of 113 patients in advanced stages of heart failure (New York Heart Association Functional Class III-IV, left ventricular ejection < 0.25) were studied. All 6-minute walks took place in an enclosed, level, measured corridor and were supervised by the same nurse. Heart rate variability was measured by using (1) a standard-deviation method and (2) Poincare plots. Data on RR intervals obtained by using 24-hour Holter monitoring were analyzed. Survival was determined at 1 year after the Holter recording. RESULTS: The results showed no significant associations between the results of the 6-minute walk and the two measures of heart rate variability. The results of the walk were related to 1-year mortality but not to the risk of sudden death. Both measures of heart rate variability had significant associations with 1-year mortality and with sudden death. However, only heart rate variability measured by using Poincare plots was a predictor of total mortality and risk of sudden death, independent of left ventricular ejection fraction, serum levels of sodium, results of the 6-minute walk test, and the standard-deviation measure of heart rate variability. CONCLUSIONS: Results of the 6-minute walk have poor association with mortality and the two measures of heart rate variability in patients with advanced-stage heart failure and a low ejection fraction. Further studies are needed to determine the optimal clinical usefulness of the 6-minute walk and heart rate variability in patients with advanced-stage heart failure.


Author(s):  
Helme Silvet ◽  
Lee Ann Hawkins

Background. Heart rate (HR) control is one of the main goals in management of patients with chronic atrial fibrillation (AF). However, rate control can be challenging in patients with heart failure (HF). The goal of our study was to determine if aggressive heart rate control in patients with both chronic AF and HF results in better exercise tolerance and/or quality of life (QOL) as compared to the “usual” care. Methods. This was a single center interventional study at VA Loma Linda Healthcare System using patients as their own controls. Patients with chronic AF and LVEF ≤ 40% were recruited. Intervention consisted of increasing doses of Metoprolol XL to achieve target resting heart rate less than 70 bpm. Clinical data was collected at baseline (“usual care”) and at follow-up (3 months) and included HR data, 6-minute walk test, QOL questionnaire (Minnesota Living with Heart Failure), and brain natriuretic peptide (BNP) levels. Paired t-test was performed to evaluate statistically significant change in these clinical measures. The study had 80% power to detect clinically significant improvement in 6-minute walk test (50 meters). Results. 20 patients were recruited with an average follow-up of 98 days. Mean age was 66 years and all the patients were male with an average LVEF of 30 ± 8% and NYHA class of II-III. Average resting HR was 94 ± 14 bpm at baseline and 85 ± 12 bpm after the intervention. Average Metoprolol XL dose at the end of the study was 121mg with the average increase of the dose during the study of 59 mg. Further increases of Metoprolol doses to achieve target HR were not tolerated by the patients. Conclusion. In this small group of patients with chronic AF and HF aggressive HR control was difficult due to patient intolerance of increasing doses of beta-blockade and was not associated with better exercise tolerance, better QOL or improved HF based on BNP measurement. Further studies are needed to establish guidelines for target HR in patients with chronic AF who also have significant HF. Clinical parameter Baseline Follow-up p-value 6-min walk test (meters) 326 ± 83 330 ± 86 0.47 QOL score 42.5 ± 19 38 ± 21 >0.5 BNP 242 ± 306 279 ± 395 >0.5 NYHA class 2.4 ± 0.7 2.2 ± 0.7 0.009


Author(s):  
Pavel O. Karchikian ◽  
Sergey A. Sayganov

Aim — to reveal the connection between the initial morphofunctional characteristics of patients and the dyna mics of changes in the diastolic function at the time, as well as during 6 months of observation after the episode of acute decompensated heart failure against the background of standard therapy and with the addition of the If-channel blocker ivabradine. Material and methods. We examined 127 patients hospitalized for the episode of the acute decompensated heart failure with a sinus rhythm and heart rate more than 85 beats per minute. Of these, 67 patients received ivabradine in addition to standard therapy, 60 patients were in control group. A 6-minute walk test, echocardiography assessment of systolic and diastolic function, electrocardiography (heart rate and rhythm) were performed on the day of admission (except for the 6-minute walk test), in 1 and 6 months later. Results. A scoring of the chance for positive dynamics of diastolic function was obtained in patients with acute decompensated heart failure, in the presence of certain initial characteristics of patients, such as: systolic pulmonary artery pressure < 37 mmHg (p < 0.005), heart rate < 95 beats per minute (p < 0.05), end diastolic size < 50 mm (p < 0.005), VE/Em* < 18 (p < 0.0005), end systolic size < 40 mm (p < 0.0005), and end systolic volume index < 40 ml/m2 (p < 0.0005), end diastolic volume index < 73 ml/m2 (p < 0.005), ejection fraction > 50% (p < 0.005), ivabradine intake (p < 0.05), relative wall thickness > 0,46 (p < 0.005), female sex. A relationship between improvement in diastolic function and improvement in results of 6-minute walk test was found: with a positive dynamics of diastolic function, patients began to walk a distance in the 6-minute walk test more by 6,9 ± 2,9 meters (p < 0.0005). Conclusion. The data obtained in our study confirm the advisability of addition ivabradine to the standard therapy of patients with acute decompensated heart failure with the found “useful” morphofunctional characteristics.


2021 ◽  
Vol Volume 16 ◽  
pp. 2545-2560
Author(s):  
Dongxing Zhao ◽  
Asghar Abbasi ◽  
Richard Casaburi ◽  
Alessandra Adami ◽  
Nicholas B Tiller ◽  
...  

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