Distinct sesquiterpene pyridine alkaloids from in Salvadoran and Peruvian Celastraceae species

In total, three sesquiterpene pyridine alkaloids, including two new compounds and a triterpene, were isolated from the n-hexane extract of the stem barks of Hippocratea excelsa. The structures of these compounds were elucidated by spectroscopic methods. Pristimerin, a naturally occurring triterpenoid, exhibited cytotoxicity against L1210 cells.

Download Full-text

Sesquiterpene pyridine alkaloids from Hippocratea excelsa

Phytochemistry ◽

10.1016/s0031-9422(02)00020-1 ◽

2002 ◽

Vol 59 (7) ◽

pp. 767-777 ◽

Cited By ~ 17

Author(s):

Masakatsu Furukawa ◽

Mitsuko Makino ◽

Taketo Uchiyama ◽

Katsuhiro Ishimi ◽

Yoshiyuki Ichinohe ◽

...

Keyword(s):

Sesquiterpene Pyridine Alkaloids

Download Full-text

Bioactive sesquiterpene pyridine alkaloids from Maytenus aquifolium

Phytochemistry ◽

10.1016/s0031-9422(97)00824-8 ◽

1998 ◽

Vol 48 (1) ◽

pp. 137-140 ◽

Cited By ~ 17

Author(s):

Joaquim Corsino ◽

Vanderlan da Silva Bolzani ◽

Ana Maria S. Pereira ◽

Suzelei Castro França ◽

Maysa Furlan

Keyword(s):

Sesquiterpene Pyridine Alkaloids

Download Full-text

Insecticidal sesquiterpene pyridine alkaloids from Euonymus species

Phytochemistry ◽

10.1016/s0031-9422(02)00335-7 ◽

2002 ◽

Vol 61 (6) ◽

pp. 699-704 ◽

Cited By ~ 34

Author(s):

Zhu Jinbo ◽

Wang Mingan ◽

Wu Wenjun ◽

Ji Zhiqing ◽

Hu Zhaonong

Keyword(s):

Euonymus Species ◽

Sesquiterpene Pyridine Alkaloids

Download Full-text

Three New Sesquiterpene Pyridine Alkaloids from Euonymus fortunei

Helvetica Chimica Acta ◽

10.1002/hlca.201000411 ◽

2011 ◽

Vol 94 (6) ◽

pp. 1139-1145 ◽

Cited By ~ 6

Author(s):

Ying Da Yang ◽

Guang Zhong Yang ◽

Mao Chuan Liao ◽

Zhi Nan Mei

Keyword(s):

Euonymus Fortunei ◽

Sesquiterpene Pyridine Alkaloids

Download Full-text

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

10.20944/preprints201608.0221.v1 ◽

2016 ◽

Author(s):

Dongsheng Fan ◽

Guo-Yuan Zhu ◽

Ting Li ◽

Zhi-Hong Jiang ◽

Li-Ping Bai

Keyword(s):

Furan Ring ◽

Fibroblast Cell ◽

2D Nmr ◽

Ring System ◽

Human Rheumatoid Arthritis ◽

Inhibitory Effects ◽

Macrocyclic Ring ◽

Spectroscopic Analyses ◽

Tripterygium Regelii ◽

Sesquiterpene Pyridine Alkaloids

Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.

Download Full-text