Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii

Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.

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Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

Molecules ◽

10.3390/molecules21091146 ◽

2016 ◽

Vol 21 (9) ◽

pp. 1146 ◽

Cited By ~ 8

Author(s):

Dongsheng Fan ◽

Guo-Yuan Zhu ◽

Ting Li ◽

Zhi-Hong Jiang ◽

Li-Ping Bai

Keyword(s):

Tripterygium Regelii ◽

Sesquiterpene Pyridine Alkaloids

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Anti-inflammatory sesquiterpene pyridine alkaloids from Tripterygium wilfordii

Fitoterapia ◽

10.1016/j.fitote.2015.06.003 ◽

2015 ◽

Vol 105 ◽

pp. 49-54 ◽

Cited By ~ 15

Author(s):

Chang Gao ◽

Xiao-Xiao Huang ◽

Ming Bai ◽

Jie Wu ◽

Jian-You Li ◽

...

Keyword(s):

Tripterygium Wilfordii ◽

Anti Inflammatory ◽

Sesquiterpene Pyridine Alkaloids

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The absolute configuration of regelidine, a novel 6-nicotinoyl dihydroagarofuran sesquiterpene alkaloid from Tripterygium regelii.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.35.4683 ◽

1987 ◽

Vol 35 (11) ◽

pp. 4683-4686 ◽

Cited By ~ 15

Author(s):

Hitoshi Hori ◽

Guo-Mao Pang ◽

Kenzo Harimaya ◽

Yoichi Iitaka ◽

Seiichi Inayama

Keyword(s):

Absolute Configuration ◽

Tripterygium Regelii ◽

The Absolute

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Tripterygium Regelii

10.5962/p.321874 ◽

1927 ◽

Vol 1 (15) ◽

pp. 58-60

Author(s):

Ernest Henry Wilson

Keyword(s):

Tripterygium Regelii

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Untargeted analysis of sesquiterpene pyridine alkaloids from the dried roots ofTripterygium wilfordiiusing high-performance liquid chromatography/electrospray ionization tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.7186 ◽

2015 ◽

Vol 29 (10) ◽

pp. 965-972 ◽

Cited By ~ 6

Author(s):

Tian Cai ◽

Ying-Gang Luo ◽

Min Zhou ◽

Dan Wang ◽

Zhi-Jun Wu ◽

...

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Electrospray Ionization ◽

High Performance ◽

Tandem Mass ◽

Untargeted Analysis ◽

Sesquiterpene Pyridine Alkaloids ◽

Ionization Tandem Mass Spectrometry

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New Sesquiterpene Pyridine Alkaloids from Hippocratea excelsa

Natural Product Communications ◽

10.1177/1934578x1801300809 ◽

2018 ◽

Vol 13 (8) ◽

pp. 1934578X1801300

Author(s):

Megumi Furukawa ◽

Masakatsu Furukawa ◽

Mitsuko Makino ◽

Taketo Uchiyama ◽

Yasuo Fujimoto ◽

...

Keyword(s):

Hexane Extract ◽

Spectroscopic Methods ◽

L1210 Cells ◽

Naturally Occurring ◽

New Compounds ◽

Sesquiterpene Pyridine Alkaloids

In total, three sesquiterpene pyridine alkaloids, including two new compounds and a triterpene, were isolated from the n-hexane extract of the stem barks of Hippocratea excelsa. The structures of these compounds were elucidated by spectroscopic methods. Pristimerin, a naturally occurring triterpenoid, exhibited cytotoxicity against L1210 cells.

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