Poster 30 Exercise Therapy in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke Like Episodes: A Case Report

PM&R ◽  
2014 ◽  
Vol 6 (9) ◽  
pp. S192
Author(s):  
Oliver Masaba ◽  
Vikram Arora
Author(s):  
Douglas Yeung Leong ◽  
Rei Yen Chee ◽  
Yit Shiang Lui

A patient with diagnosed MELAS (mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) syndrome had developed psychological and behavioural disturbances at a later stage of his illness. Psychiatric care for this patient would not be possible without a multidisciplinary team approach involving multi-prong interventions from the different team members.


2021 ◽  
Vol 14 (4) ◽  
pp. e235111
Author(s):  
Deepa Balachandran Nair ◽  
Mariana Bloomfield ◽  
Rajeswari Parasuraman ◽  
David T Howe

The syndrome of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a rare mitochondrial disease with few documented cases in pregnancy. In this case report, we discuss the presentation and management of a 39-year-old grand multiparous lady with MELAS syndrome, which was diagnosed prior to her eighth pregnancy, discuss potential implications of the condition in pregnancy and summarise the current guidelines for the management of this rare condition.


2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Benedicte Le Tinier ◽  
Kuntheavy Ing Lorenzini ◽  
Arnaud Joal ◽  
Begona Martinez De Tejada

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuji Suzuki ◽  
Matsuyuki Doi ◽  
Yoshiki Nakajima

Abstract Background Systemic anesthetic management of patients with mitochondrial disease requires careful preoperative preparation to administer adequate anesthesia and address potential disease-related complications. The appropriate general anesthetic agents to use in these patients remain controversial. Case presentation A 54-year-old woman (height, 145 cm; weight, 43 kg) diagnosed with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes underwent elective cochlear implantation. Infusions of intravenous remimazolam and remifentanil guided by patient state index monitoring were used for anesthesia induction and maintenance. Neither lactic acidosis nor prolonged muscle relaxation occurred in the perioperative period. At the end of surgery, flumazenil was administered to antagonize sedation, which rapidly resulted in consciousness. Conclusions Remimazolam administration and reversal with flumazenil were successfully used for general anesthesia in a patient with mitochondrial disease.


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