Causal role of cross-frequency coupling in distinct components of cognitive control

2021 ◽  
pp. 102033
Author(s):  
Justin Riddle ◽  
Amber McFerren ◽  
Flavio Frohlich
Keyword(s):  
Cognitive Control ◽  
Causal Role ◽  
Frequency Coupling ◽  
Cross Frequency Coupling

scholarly journals Theta and gamma oscillations in the rat hippocampus during attentive lever pressing

2018 ◽  
Author(s):  
A Lipponen ◽  
H Tanila ◽  
K Gurevicius
Keyword(s):  
Gamma Oscillations ◽  
Water Port ◽  
Lever Pressing ◽  
Gamma Rhythms ◽  
Frequency Coupling ◽  
Theta Phase ◽  
Hippocampal Theta ◽  
Dentate Hilus ◽  
Cross Frequency Coupling

AbstractThe hippocampus is known to be pivotal for spatial memory but emerging evidence suggests its contribution to temporal memories as well. However, it is not clear how the hippocampus represents time and how it synchronizes spatial and temporal presentations into a coherent memory. We assessed the specific role of hippocampal theta and gamma oscillations and their interaction in short-term timing of motor reactions. Rats were trained to maintain lever pressing for 2.5 s and then to quickly release the lever and retrieve water reward from a nearby water port guided by a cue light. In essence, this task allows observation of hippocampal rhythms during timed anticipation when no overt movements take place. Then we implanted wire electrodes to five hippocampal layers for recording local field potentials during the task. Consistent with earlier reports, theta showed a declining trend during the lever press. We also found that fast-gamma declined in tandem with theta while slow-gamma showed an opposite trend. Theta-phase to gamma-amplitude cross-frequency coupling measured with modulation index (MI) varied significantly between the three task phases. Interestingly, also changes in MI were opposite for fast- and slow-gamma. The MI was also related to the task performance, so that during omission trials the MI for fast-gamma in CA1 was smaller than during trials with premature lever release. In addition, the MI in dentate hilus was higher during all error trials than during correctly performed trials. Collectively, these data suggest an important role of synchronization of hippocampal theta and gamma rhythms to timing of cued motor reactions.

scholarly journals The functional role of cross-frequency coupling

2010 ◽  
Vol 14 (11) ◽  
pp. 506-515 ◽  
Author(s):  
Ryan T. Canolty ◽  
Robert T. Knight
Keyword(s):  
Functional Role ◽  
Frequency Coupling ◽  
Cross Frequency Coupling

scholarly journals Intrinsic connectome organization across temporal scales: New insights from cross-modal approaches

2020 ◽  
Vol 4 (1) ◽  
pp. 1-29 ◽  
Author(s):  
Sepideh Sadaghiani ◽  
Jonathan Wirsich
Keyword(s):  
Brain Function ◽  
Structural Connectivity ◽  
Brain Organization ◽  
Whole Brain ◽  
Intrinsic Connectivity ◽  
Frequency Coupling ◽  
Brain Functional Connectivity ◽  
Brain Behavior ◽  
Cross Frequency Coupling

The discovery of a stable, whole-brain functional connectivity organization that is largely independent of external events has drastically extended our view of human brain function. However, this discovery has been primarily based on functional magnetic resonance imaging (fMRI). The role of this whole-brain organization in fast oscillation-based connectivity as measured, for example, by electroencephalography (EEG) and magnetoencephalography (MEG) is only beginning to emerge. Here, we review studies of intrinsic connectivity and its whole-brain organization in EEG, MEG, and intracranial electrophysiology with a particular focus on direct comparisons to connectome studies in fMRI. Synthesizing this literature, we conclude that irrespective of temporal scale over four orders of magnitude, intrinsic neurophysiological connectivity shows spatial similarity to the connectivity organization commonly observed in fMRI. A shared structural connectivity basis and cross-frequency coupling are possible mechanisms contributing to this similarity. Acknowledging that a stable whole-brain organization governs long-range coupling across all timescales of neural processing motivates researchers to take “baseline” intrinsic connectivity into account when investigating brain-behavior associations, and further encourages more widespread exploration of functional connectomics approaches beyond fMRI by using EEG and MEG modalities.

scholarly journals Reconfiguration of Amplitude Driven Dominant Coupling Modes (DoCM) mediated by α-band in Adolescents with Schizophrenia Spectrum Disorders

2020 ◽  
Author(s):  
Stavros I. Dimitriadis
Keyword(s):  
Schizophrenia Spectrum Disorders ◽  
Dynamic Functional Connectivity ◽  
Alpha Frequency ◽  
Schizophrenia Spectrum ◽  
Network Flexibility ◽  
Frequency Coupling ◽  
Spectrum Disorders ◽  
Cross Frequency Coupling ◽  
Flexibility Index

AbstractElectroencephalography (EEG) based biomarkers have been shown to correlated with the presence of psychotic disorders. Increased delta and decreased alpha power in psychosis indicate an abnormal arousal state. We investigated brain activity across the basic EEG frequencies and also dynamic functional connectivity of both intra and cross-frequency coupling that could reveal a neurophysiological biomarker linked to an aberrant modulating role of alpha frequency in adolescents with schizophrenia spectrum disorders (SSDs).A dynamic functional connectivity graph (DFCG) has been estimated using the imaginary part of phase lag value (iPLV) and correlation of the envelope (corrEnv). We analyzed DFCG profiles of electroencephalographic resting state (eyes closed) recordings of healthy controls (HC) (n=39) and SSDs subjects (n=45) in basic frequency bands {δ,θ,α1,α2,β1,β2,γ}. In our analysis, we incorporated both intra and cross-frequency coupling modes. Adopting our recent Dominant Coupling Mode (DoCM) model leads to the construction of an integrated DFCG (iDFCG) that encapsulates the functional strength and the DoCM of every pair of brain areas.We revealed significantly higher ratios of delta/alpha1,2 power spectrum in SSDs subjects versus HC. The probability distribution (PD) of amplitude driven DoCM mediated by alpha frequency differentiated SSDs from HC with absolute accuracy (100%). The network Flexibility Index (FI) was significantly lower for subjects with SSDs compared to the HC group.Our analysis supports a central role of alpha frequency alterations in the neurophysiological mechanisms of SSDs. Currents findings open up new diagnostic pathways to clinical detection of SSDs and supports the design of rational neurofeedback training.HighlightsRatios of delta/alpha1,2 relative power spectrum were significant higher in SSDs subjects compared to HCProbability distribution (PD) of amplitude driven DoCM mediated by alpha frequency differentiated SSDs from HC with 100%Network Flexibility index (FI) was significant lower for subjects with SSDs compared to HC group.

scholarly journals Prefrontal Lesions Disrupt Posterior Alpha–Gamma Coordination of Visual Working Memory Representations

2021 ◽  
pp. 1-13
Author(s):  
Saeideh Davoudi ◽  
Mohsen Parto Dezfouli ◽  
Robert T. Knight ◽  
Mohammad Reza Daliri ◽  
Elizabeth L. Johnson
Keyword(s):  
Working Memory ◽  
Feature Selection ◽  
Visual Representations ◽  
Temporal Position ◽  
Memory Representations ◽  
Frequency Coupling ◽  
Oscillatory Mechanisms ◽  
Cross Frequency Coupling ◽  
Selection Of

Abstract How does the human brain prioritize different visual representations in working memory (WM)? Here, we define the oscillatory mechanisms supporting selection of “where” and “when” features from visual WM storage and investigate the role of pFC in feature selection. Fourteen individuals with lateral pFC damage and 20 healthy controls performed a visuospatial WM task while EEG was recorded. On each trial, two shapes were presented sequentially in a top/bottom spatial orientation. A retro-cue presented mid-delay prompted which of the two shapes had been in either the top/bottom spatial position or first/second temporal position. We found that cross-frequency coupling between parieto-occipital alpha (α; 8–12 Hz) oscillations and topographically distributed gamma (γ; 30–50 Hz) activity tracked selection of the distinct cued feature in controls. This signature of feature selection was disrupted in patients with pFC lesions, despite intact α–γ coupling independent of feature selection. These findings reveal a pFC-dependent parieto-occipital α–γ mechanism for the rapid selection of visual WM representations.

Do Writing Directions Influence How People Map Space onto Time?

2018 ◽  
Vol 77 (4) ◽  
pp. 173-184
Author(s):  
Wenxing Yang ◽  
Ying Sun
Keyword(s):  
Mental Representations ◽  
Space Time ◽  
Horizontal Axis ◽  
Causal Role ◽  
Writing Systems ◽  
Temporal Cognition ◽  
Japanese Speakers ◽  
Psychological Experiments ◽  
Vertical Up

Abstract. The causal role of a unidirectional orthography in shaping speakers’ mental representations of time seems to be well established by many psychological experiments. However, the question of whether bidirectional writing systems in some languages can also produce such an impact on temporal cognition remains unresolved. To address this issue, the present study focused on Japanese and Taiwanese, both of which have a similar mix of texts written horizontally from left to right (HLR) and vertically from top to bottom (VTB). Two experiments were performed which recruited Japanese and Taiwanese speakers as participants. Experiment 1 used an explicit temporal arrangement design, and Experiment 2 measured implicit space-time associations in participants along the horizontal (left/right) and the vertical (up/down) axis. Converging evidence gathered from the two experiments demonstrate that neither Japanese speakers nor Taiwanese speakers aligned their vertical representations of time with the VTB writing orientation. Along the horizontal axis, only Japanese speakers encoded elapsing time into a left-to-right linear layout, which was commensurate with the HLR writing direction. Therefore, two distinct writing orientations of a language could not bring about two coexisting mental time lines. Possible theoretical implications underlying the findings are discussed.

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