Selective separation of the homologues of baicalin and baicalein from Scutellaria baicalensis Georgi using a recyclable ionic liquid-based liquid-liquid extraction system

2021 ◽  
Vol 103 ◽  
pp. 1-8
Author(s):  
Lingqi Wang ◽  
Changyong Cai ◽  
Jiajia Liu ◽  
Zhijian Tan
Keyword(s):  
Ionic Liquid ◽  
Liquid Extraction ◽  
Selective Separation ◽  
Scutellaria Baicalensis ◽  
Extraction System ◽  
Scutellaria Baicalensis Georgi ◽  
Liquid Liquid Extraction

Selective Separation of Sr(II) from High Level Radioactive Waste Using Crown Ether in Ionic Liquid Extraction System

2016 ◽  
Vol 27 (2) ◽  
pp. 21-26 ◽  
Author(s):  
Tadayuki TAKAHASHI ◽  
Tatsuya ITO ◽  
Seong-Yun KIM ◽  
Haruaki TOKUDA ◽  
Nobumichi NAGANO ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Crown Ether ◽  
Radioactive Waste ◽  
Liquid Extraction ◽  
Selective Separation ◽  
Extraction System ◽  
High Level Radioactive Waste ◽  
High Level

scholarly journals Development of trace analysis for alkyl methanesulfonates in the delgocitinib drug substance using GC-FID and liquid–liquid extraction with ionic liquid

2020 ◽  
Vol 18 (1) ◽  
pp. 1020-1029
Author(s):  
Shinkichi Nomura ◽  
Yoshiharu Ito ◽  
Shigehiko Takegami ◽  
Tatsuya Kitade
Keyword(s):  
Ionic Liquid ◽  
Trace Analysis ◽  
Direct Injection ◽  
Liquid Extraction ◽  
Drug Substance ◽  
Flame Ionization ◽  
Liquid Liquid Extraction ◽  
Accuracy And Precision ◽  
Sensitivity And Selectivity ◽  
Chloride Water

AbstractAlkyl methanesulfonates are genotoxic impurities that should be limited to an intake of not more than 1.5 µg/day, as regulated by the International Council for Harmonization guideline M7. We herein report a trace analysis of methyl methanesulfonate (MMS), ethyl methanesulfonate (EMS), and isopropyl methanesulfonate (IPMS) in the delgocitinib drug substance using liquid–liquid extraction, with an ionic liquid as the sample-solving medium, and direct injection gas chromatography detected with a flame-ionization detector. The proposed method takes advantage of the fine solubility of ionic liquids toward the drug substance, the good extraction efficiency of alkyl methanesulfonates in liquid–liquid extraction using the Chem Elut cartridge with low-polar organic solvents, and the ability of alkyl methanesulfonates to concentrate in minimum amounts of organic solvent, resulting in excellent sensitivity and selectivity. Specifically, for the preparation of the sample solution, a mixture of 1-butyl-3-methylimidazolium chloride, water, and acetonitrile was used as the sample-solving media, extracted with diethyl ether, and the eluent was concentrated to 1 mL. The method showed good linearity, accuracy, and precision from 1 to 5 ppm, and the limits of detection of MMS, EMS, and IPMS were 0.1, 0.05, and 0.05 ppm, respectively.

scholarly journals Selective Separation of Amines from Continuous Processes using Automated pH Controlled Extraction

2021 ◽  
Author(s):  
Luke Power ◽  
Adam D. Clayton ◽  
William Reynolds ◽  
David Hose ◽  
Caroline Ainsworth ◽  
...  
Keyword(s):  
Liquid Extraction ◽  
Selective Separation ◽  
Continuous Processing ◽  
Online Analysis ◽  
Continuous Processes ◽  
Liquid Liquid Extraction ◽  
Ph Controlled

We present a rapid continuous processing methodology to screen for the optimal, selective, liquid-liquid extraction conditions, from a typical post-reaction mixture of amines, using both inline and online analysis to...

scholarly journals Homogeneous Liquid-Liquid Extraction Method for Selective Separation and Preconcentration of Trace Amounts of Palladium

2009 ◽  
Vol 6 (4) ◽  
pp. 1077-1084 ◽  
Author(s):  
Mohammad Reza Jamali ◽  
Yaghoub Assadi ◽  
Reyhaneh Rahnama Kozani ◽  
Farzaneh Shemirani
Keyword(s):  
Extraction Method ◽  
Limit Of Detection ◽  
Liquid Extraction ◽  
Selective Separation ◽  
Complexing Agent ◽  
Homogeneous Liquid ◽  
Liquid Liquid Extraction ◽  
Relative Standard ◽  
Separation And Preconcentration ◽  
Ternary Component System

A simple and effective homogeneous liquid-liquid extraction method for selective separation, preconcentration and spectrophotometric determination of palladium(II) ion was developed by using a ternary component system (water / tetrabutylammonium ion (TBA+) / chloroform). The phase separation phenomenon occurred by an ion–pair formation of TBA+and perchlorate ion. Thio-Michler’s ketone (TMK), 4, 4ˊ-bis (dimethylamino) thiobenzophenone, was used as a complexing agent. After optimization of complexation and extraction conditions ([TMK]=5.0x10-2mol L-1, [TBA+] = 2.0×10-2mol L-1, [CHCl3] = 60.0 µL, [ClO4-] = 2.5×10-2mol L-1and pH= 3.0), a preconcentration factor 10 was obtained for 10 mL of sample. The analytical curve was linear in the range of 2-100 ng mL-1and the limit of detection was 0.4 ng mL-1. The relative standard deviation was 3.2% (n=10). Accuracy and application of the method was estimated by using test samples of natural and synthetic water spiked with different amounts of palladium(II) ion. The method is very simple and inexpensive.

scholarly journals Liquid-liquid extraction of cadmium(II) by TIOACl (tri-iso-octylammonium chloride) ionic liquid and its application to a TIOACl impregnated carbon nanotubes system

2015 ◽  
Vol 51 (3) ◽  
pp. e051 ◽  
Author(s):  
Francisco J. Alguacil ◽  
Irene García-Díaz ◽  
Félix A. López ◽  
Olga Rodríguez
Keyword(s):  
Carbon Nanotubes ◽  
Ionic Liquid ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction
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