Soft-Transition Sub-PCA Monitoring of Batch Processes

Batch or semi-batch processes have been utilized to produce high-value-added products in the biological, food, semi-conductor industries. Batch process, such as fermentation, polymerization, and pharmacy, is highly sensitive to the abnormal changes in operating condition. Monitoring of such processes is extremely important in order to get higher productivity. However, it is more difficult to develop an exact monitoring model of batch processes than that of continuous processes, due to the common natures of batch process: non-steady, time-varying, finite duration, and nonlinear behaviors. The lack of exact monitoring model in most batch processes leads that an operator cannot identify the faults when they occurred. Therefore, effective techniques for monitoring batch process exactly are necessary in order to remind the operator to take some corrective actions before the situation becomes more dangerous.

The Woman Role in Change Leadership : دور المرأة في قيادة التغيير

There is no doubt that great leaders are created step by step through a set of continuous processes that support and refine their capabilities, and accordingly we find that most studies have confirmed that the characteristics of women leaders are not sufficient alone in activating their roles as much as the surrounding environment should help in that. She plays a prominent role in strengthening the conditions for empowering women and providing the necessary conditions for her creativity, whether through her leadership roles or her regular roles, the study aims to identify the role that women play at the level of leading change in various areas of life, whether economic, political, social, and other other fields, by identifying the most prominent leadership characteristics and the skills that they should have, and an attempt to evaluate these different characteristics and capabilities and stand On the extent to which these characteristics contribute to leading the change process in general at any level of the state or different institutions, and the study also aimed to identify the most important methods and strategies that women use in leading change, and the effect of these strategies on their ability to lead change, and the study did not stop. Up to that point, it also sought to highlight the most important challenges facing women in societies, as well as to address the comparison of leadership style between men and women, by relying on the descriptive approach and the analytical method for the contribution of both approaches in the researcher's point of view in achieving the basic purpose of this study, and the most prominent results were The study is that women have a prominent role in society in general, from their role in the family to their role in the highest leadership positions that take on Here, the study also proved that women have sufficient characteristics and qualities to qualify them to play a fundamental role in leading the process of change, and that they have the ability to carry out a set of different activities that lead towards change, whether those activities are related to the follow- up or development process and other activities that lead towards change on the one hand. The level of organizations and others, in addition to emphasizing that women are more cautious than men at the level of decision- making, but at the same time they are superior in terms of courage and ability to plan for the future, and in general, if women play a pivotal role in leadership, and therefore they can be described as fighting.

Opportunities and Problems of the Consensus Conferences in the Care Robotics

Care robots represent an opportunity for the health domain. The use of these devices has important implications. They can be used in surgical operating rooms in important and delicate clinical interventions, in motion, in training-and-simulation, and cognitive and rehabilitation processes. They are involved in continuous processes of evolution in technology and clinical practice. Therefore, the introduction into routine clinical practice is difficult because this needs the stability and the standardization of processes. The agreement tools, in this case, are of primary importance for the clinical acceptance and introduction. The opinion focuses on the Consensus Conference tool and: (a) highlights its potential in the field; (b) explores the state of use; (c) detects the peculiarities and problems (d) expresses ideas on how improve its diffusion.

Evolution of Open Quantum Systems: Time Scales, Stochastic and Continuous Processes

The study of the physical properties of open quantum systems is at the heart of many investigations, which aim to describe their dynamical evolution on theoretical ground and through physical realizations. Here, we develop a presentation of different aspects, which characterize these systems and confront different physical situations that can be realized leading to systems, which experience Markovian, non-Markovian, divisible or non-divisible interactions with the environments to which they are dynamically coupled. We aim to show how different approaches describe the evolution of quantum systems subject to different types of interactions with their environments.Quanta 2021; 10: 42–54.

A Case Study on Remote Instrumentation of Vibration and Temperature in Bearing Housings

Data collection is one of the most relevant topics of modern automation and industry. It is usually a costly and time-consuming task, especially in continuous processes. Our case study takes place in a sugar cane mill. The required continuous operation of a belt conveyor for bagasse transportation makes it a critical system in the overall production process. Therefore, a predictive maintenance tool is highly applicable here. We identified bearing housings as critical points for data collection intended for prognostics of the conveyor. However, given the number of points, the cost of a commercial solution becomes unfeasible by our company. This paper reports the development of low-cost devices for measurements and wireless transmission of vibration and temperature data from bearing housings. We assessed several sensor options and made decisions based on a cost-suitability commitment, which led to the design of the electronic devices. The devices were tested for correct operation, reliability (99%), and relative measurement errors under 1.2%. From the tests, we conclude that our proposal is appropriate for our case study’s industrial needs and budget restrictions.

Off-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Processes in Single-Use Bioreactors

In mammalian cell culture, especially in pharmaceutical manufacturing and research, biomass and metabolic monitoring are mandatory for various cell culture process steps to develop and, finally, control bioprocesses. As a common measure for biomass, the viable cell density (VCD) or the viable cell volume (VCV) is widely used. This study highlights, for the first time, the advantages of using VCV instead of VCD as a biomass depiction in combination with an oxygen-uptake- rate (OUR)-based soft sensor for real-time biomass estimation and process control in single-use bioreactor (SUBs) continuous processes with Chinese hamster ovary (CHO) cell lines. We investigated a series of 14 technically similar continuous SUB processes, where the same process conditions but different expressing CHO cell lines were used, with respect to biomass growth and oxygen demand to calibrate our model. In addition, we analyzed the key metabolism of the CHO cells in SUB perfusion processes by exometabolomic approaches, highlighting the importance of cell-specific substrate and metabolite consumption and production rate qS analysis to identify distinct metabolic phases. Cell-specific rates for classical mammalian cell culture key substrates and metabolites in CHO perfusion processes showed a good correlation to qOUR, yet, unexpectedly, not for qGluc. Here, we present the soft-sensoring methodology we developed for qPyr to allow for the real-time approximation of cellular metabolism and usage for subsequent, in-depth process monitoring, characterization and optimization.

Activity patterns of medium and large mammals in two savanna ecosystems in the Colombian Llanos

Neotropical savannas have undergone continuous processes of landscape transformation (e.g., agriculture, oil, gas, and hydrocarbon industry) and very little is known about the ecology and natural history of key biological groups such as terrestrial mammals while the information on behavioral aspects of mammalian species in these ecosystems is very scarce. Here, we aimed to describe the activity patterns of medium and large mammals in two savanna ecosystems in the Colombian Llanos. A set of 60 camera traps was installed in the two ecosystems for 35 days (2100 camera days). We described the activity patterns of nine predominantly nocturnal species. We found no difference in circadian distributions of mammals between ecosystems. Cuniculus paca Linnaeus 1758 and Dasyprocta fuliginosa Wagler 1832 showed patterns of exclusion probably due to competition whereas other species like Tamandua tetradactyla Linnaeus1758 and Myrmecophaga tridactyla Linnaeus 1758 displayed similar activity patterns. We highlight the importance of savannas for the conservation of these species and discuss the relevance of studies on activity patterns for mammal ecology and conservation in Neotropical savannas.

Electrocoagulation Process: An Approach to Continuous Processes, Reactors Design, Pharmaceuticals Removal, and Hybrid Systems—A Review

The electrocoagulation (EC) process has been widely studied in recent years to remove a wide range of contaminants present in different types of water: fluorides, arsenic, heavy metals, organic matter, colorants, oils, and recently, pharmaceutical compounds. However, most of the studies have been aimed at understanding the process factors that have the most significant effect on efficiency, and these studies have been mainly on a batch process. Therefore, this review is focused on elucidating the current state of development of this process and the challenges it involves transferring to continuous processes and the recent exploration of its potential use in the removal of pharmaceutical contaminants and its implementation with other technologies.

From Geometry to Coherent Dissipative Dynamics in Quantum Mechanics

Starting from the geometric description of quantum systems, we propose a novel approach to time-independent dissipative quantum processes according to which energy is dissipated but the coherence of the states is preserved. Our proposal consists of extending the standard symplectic picture of quantum mechanics to a contact manifold and then obtaining dissipation by using appropriate contact Hamiltonian dynamics. We work out the case of finite-level systems for which it is shown, by means of the corresponding contact master equation, that the resulting dynamics constitute a viable alternative candidate for the description of this subclass of dissipative quantum systems. As a concrete application, motivated by recent experimental observations, we describe quantum decays in a 2-level system as coherent and continuous processes.