Submerged culture of Penicillium sclerotiorum for production of rotiorin alkaloids by using biosynthetic and chemical catalytic cascade reactions

2021 ◽  
Vol 104 ◽  
pp. 10-18
Author(s):  
Shu Wu ◽  
Lujie Liu ◽  
Xuehong Zhang ◽  
Zhilong Wang
Keyword(s):  
Submerged Culture ◽  
Cascade Reactions ◽  
Penicillium Sclerotiorum

Submerged culture of marine-derived Penicillium sclerotiorum FS50 to produce sclerotiorin

2019 ◽  
Vol 79 ◽  
pp. 28-31 ◽  
Author(s):  
Qiao Xin ◽  
Tao Pan ◽  
Wei-Min Zhang ◽  
Zhilong Wang
Keyword(s):  
Submerged Culture ◽  
Penicillium Sclerotiorum

scholarly journals Plant metabolite 5-pentadecyl resorcinol is produced by the Amazonian fungus Penicillium sclerotiorum LM 5679

2022 ◽  
Vol 82 ◽  
Author(s):  
L. A. Oliveira ◽  
M. M. Macedo ◽  
J. L. S. Rodrigues ◽  
E. S. Lima ◽  
P. G. Hamill ◽  
...  
Keyword(s):  
Secondary Metabolite ◽  
Culture System ◽  
Submerged Culture ◽  
Penicillium Species ◽  
Antimicrobial Substances ◽  
Penicillium Sclerotiorum ◽  
Plant Metabolite ◽  
Diverse Plant Species ◽  
Layer Chromatography ◽  
Diverse Plant

Abstract Since the classic studies of Alexander Flemming, Penicillium strains have been known as a rich source of antimicrobial substances. Recent studies have identified novel metabolites produced by Penicillium sclerotiorum that have antibacterial, antifouling and pharmaceutical activities. Here, we report the isolation of a P. sclerotiorum (LM 5679) from Amazonian soil and carry out a culture-based study to determine whether it can produce any novel secondary metabolite(s) that are not thus-far reported for this genus. Using a submerged culture system, secondary metabolites were recovered by solvent extract followed by thin-layer chromatography, nuclear magnetic resonance, and mass spectroscopy. One novel secondary metabolite was isolated from P. sclerotiorum (LM 5679); the phenolic compound 5-pentadecyl resorcinol widely known as an antifungal, that is produced by diverse plant species. This metabolite was not reported previously in any Penicillium species and was only found once before in fungi (that time, in a Fusarium). Here, we discuss the known activities of 5-pentadecyl resorcinol in the context of its mode-of-action as a hydrophobic (chaotropicity-mediated) stressor.

Optimization of biomass production with enhanced bioactive compound content by the medicinal mushroom Ganoderma australe under submerged culture

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
LM Papaspyridi ◽  
E Topakas ◽  
N Aligiannis ◽  
P Christakopoulos ◽  
AL Skaltsounis ◽  
...  
Keyword(s):  
Biomass Production ◽  
Submerged Culture ◽  
Bioactive Compound ◽  
Medicinal Mushroom ◽  
Ganoderma Australe
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