The main goal of this chapter will be the clarification of SME´s in Slovak republic as the main creator of value in the Slovak republic, which is one of the semi-developed countries in EU. In the Slovak Republic have small and medium enterprises irreplaceable role particularly in job creation and regional development. This chapter has three main sections, which are interlinked. First main section is about the current conditions of SMEs in Slovakia, where are explained in detail business environment in Slovakia and also support for SMEs. Second main section deals with SMEs and international cooperation, where are described business risk, internationalisation of SMEs in EU markets and analysis of SMEs possibilities. Third main section is about entry strategy into foreign markets and competitiveness of SMEs and in this section you can find entry strategies of enterprise on foreign markets and competitiveness of Slovakia and Slovak SMEs.