This chapter, which is the first part of fundamental research related to optimization of SMEs knowledge management, elaborates relevant key optimization criteria. First section deals with optimizing electronic forms of communication, web site material, management effectiveness, customer management and procedures for electronic responses, channels of communication, SME cooperation mechanisms. In the second part analyzed is knowledge management optimization, modernization of SMEs, the level of use of modern information, development of employees and partners, financing the development of IT employees, the budget for information technology, innovative knowledge management in budget planning, the benefits of electronic payment cards, communication of employees and management and IT innovation. Exploration of these questions further examines impact of new technologies, IT in optimizing the development of competitive capacity and advantages from SME technological inputs and outputs. Finally, the chapter offers appropriate conclusions and recommendations.