The role of NGF and IL-2 serum level in assisting the diagnosis in first episode schizophrenia

2011 ◽  
Vol 189 (1) ◽  
pp. 72-76 ◽  
Author(s):  
Peng Xiong ◽  
Yong Zeng ◽  
Jing Wan ◽  
Diana Huang XiaoHan ◽  
Deyong Tan ◽  
...  
Keyword(s):  
Serum Level ◽  
First Episode ◽  
First Episode Schizophrenia

scholarly journals The Role of Butyric Acid in Treatment Response in Drug-Naïve First Episode Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Xue Li ◽  
Xiaoduo Fan ◽  
Xiuxia Yuan ◽  
Lijuan Pang ◽  
Shaohua Hu ◽  
...  
Keyword(s):  
Treatment Response ◽  
Butyric Acid ◽  
Serum Levels ◽  
First Episode ◽  
Healthy Controls ◽  
Significant Difference ◽  
Drug Naïve ◽  
First Episode Schizophrenia ◽  
Risperidone Treatment

Background: Butyric acid, a major short-chain fatty acid (SCFA), has an important role in the microbiota–gut–brain axis and brain function. This study investigated the role of butyric acid in treatment response in drug-naïve first episode schizophrenia.Methods: The study recruited 56 Chinese Han schizophrenia inpatients with normal body weight and 35 healthy controls. Serum levels of butyric acid were measured using Gas Chromatography-Mass Spectrometer (GC-MS) analysis at baseline (for all participants) and 24 weeks after risperidone treatment (for patients). Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) for patients at both time points.Results: At baseline, there was no significant difference in serum levels of butyric acid between patients and healthy controls (p = 0.206). However, there was a significant increase in serum levels of butyric acid in schizophrenia patients after 24-week risperidone treatment (p = 0.030). The PANSS total and subscale scores were decreased significantly after 24-week risperidone treatment (p's < 0.001). There were positive associations between baseline serum levels of butyric acid and the reduction ratio of the PANSS total and subscale scores after controlling for age, sex, education, and duration of illness (p's < 0.05). Further, there was a positive association between the increase in serum levels of butyric acid and the reduction of the PANSS positive symptoms subscale scores (r = 0.38, p = 0.019) after controlling for potential confounding factors.Conclusions: Increased serum levels of butyric acid might be associated with a favorable treatment response in drug-naïve, first episode schizophrenia. The clinical implications of our findings were discussed.

The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naïve patients with first-episode schizophrenia treated with risperidone

2010 ◽  
Vol 66 (11) ◽  
pp. 1109-1117 ◽  
Author(s):  
Nikolina Jovanović ◽  
Nada Božina ◽  
Mila Lovrić ◽  
Vesna Medved ◽  
Miro Jakovljević ◽  
...  
Keyword(s):  
First Episode ◽  
Drug Naïve ◽  
First Episode Schizophrenia

scholarly journals The Influence Of Culture On The Process Of Recovery From A First Episode Schizophrenia

2021 ◽  
Author(s):  
Melanie A. Ramiro
Keyword(s):  
Cultural Identity ◽  
Sense Of Self ◽  
Illness Experience ◽  
First Episode ◽  
Future Research ◽  
Bridge To Recovery ◽  
Positive Sense ◽  
Qualitative Descriptive ◽  
First Episode Schizophrenia

The literature indicates that aspects of culture have the potential to influence recovery from first episode schizophrenia (FES). The purpose of this study was to describe the infl uence of culture on the process of recovery for individuals with first episode schizophrenia. This study employed a qualitative descriptive methodology and elicited the experience of five male participants, who self-identified that culture influenced their recovery from FES. The three categories that emerged from the data are: ‘Emerging Cultural Identity,’ ‘Cultural Identity and Describing the Illness Experience,’ and ‘Cultural Identity: A Bridge to Recovery.’ A distinctive feature of this study is that participants turned toward their cultural identity to facilitate their process of recovery from a FES and maintain a positive sense of self. This study offers a preliminary understanding of the role of culture in recovery from FES and suggests implications for clinical practice, future research and theory.

scholarly journals Certifiable Disability in First Episode Schizophrenia: The Role of Adherence to Antipsychotic Treatment

2014 ◽  
Vol 1 (2) ◽  
pp. 55-59 ◽  
Author(s):  
Channaveerachari Naveen Kumar ◽  
Jagadisha Thirthalli ◽  
Mounesh Yadav ◽  
Bangalore N. Gangadhar ◽  
Mathew Varghese ◽  
...  
Keyword(s):  
First Episode ◽  
Antipsychotic Treatment ◽  
First Episode Schizophrenia

The Psychobiology of First-Episode Schizophrenia

1995 ◽  
Vol 40 (7_suppl) ◽  
pp. 33-37 ◽  
Author(s):  
Em Waring
Keyword(s):  
Response Prediction ◽  
First Episode ◽  
Neuroleptic Treatment ◽  
Extrapyramidal Syndromes ◽  
First Onset ◽  
Clinical Interest ◽  
First Episode Schizophrenia ◽  
Relapse Rates ◽  
First Episode Of Schizophrenia

Objective: To examine research and clinical interest in the first episode of schizophrenia. Pathobiological features have been shown to be a consequence of the disorder rather than the effects of chronicity, drug treatment or institutionalization. There is increasing evidence that ventricular enlargement is a robust finding and hypofrontality on PET and SPECT is associated more with symptomatology than with neuroleptic treatment. Results: Neuroleptic threshold studies suggest that lower daily dosages and onset of medication may be the most important response prediction parameters. Conclusion: The role of novel antipsychotics in the treatment of first-onset schizophrenia merits investigation for lower rates of extrapyramidal syndromes and tardive dyskinesia. To reduce relapse rates, psychiatrists need to introduce practice standards employing those biopsychosocial features in the management of first-episode schizophrenia.

scholarly journals The Influence Of Culture On The Process Of Recovery From A First Episode Schizophrenia

2021 ◽  
Author(s):  
Melanie A. Ramiro
Keyword(s):  
Cultural Identity ◽  
Sense Of Self ◽  
Illness Experience ◽  
First Episode ◽  
Future Research ◽  
Bridge To Recovery ◽  
Positive Sense ◽  
Qualitative Descriptive ◽  
First Episode Schizophrenia

The literature indicates that aspects of culture have the potential to influence recovery from first episode schizophrenia (FES). The purpose of this study was to describe the infl uence of culture on the process of recovery for individuals with first episode schizophrenia. This study employed a qualitative descriptive methodology and elicited the experience of five male participants, who self-identified that culture influenced their recovery from FES. The three categories that emerged from the data are: ‘Emerging Cultural Identity,’ ‘Cultural Identity and Describing the Illness Experience,’ and ‘Cultural Identity: A Bridge to Recovery.’ A distinctive feature of this study is that participants turned toward their cultural identity to facilitate their process of recovery from a FES and maintain a positive sense of self. This study offers a preliminary understanding of the role of culture in recovery from FES and suggests implications for clinical practice, future research and theory.

The nature of anhedonia and avolition in patients with first-episode schizophrenia

2015 ◽  
Vol 46 (2) ◽  
pp. 437-447 ◽  
Author(s):  
S. S. Y. Lui ◽  
A. C. Y. Liu ◽  
W. W. H. Chui ◽  
Z. Li ◽  
F. Geng ◽  
...  
Keyword(s):  
Working Memory ◽  
Chronic Schizophrenia ◽  
Memory Deficits ◽  
First Episode ◽  
Affective Experiences ◽  
The Moment ◽  
First Episode Schizophrenia ◽  
Experienced Emotion ◽  
Experience Emotion

BackgroundPatients with schizophrenia have intact ability to experience emotion, but empirical evidence suggests that they fail to translate emotional salience into effortful behaviour. Previous research in patients with chronic schizophrenia suggests that working memory is important in integrating emotion and behaviour. This study aimed to examine avolition and anhedonia in patients with first-episode schizophrenia and clarify the role of working memory in emotion–behaviour coupling.MethodWe recruited 72 participants with first-episode schizophrenia and 61 healthy controls, and used a validated emotion-inducing behavioural paradigm to measure participants' affective experiences and how experienced emotion coupled with behaviour. Participants were given the opportunity to expend effort to increase or decrease their exposure to emotion-inducing photographs. Participants with schizophrenia having poor working memory were compared with those with intact working memory in their liking and emotion–behaviour coupling.ResultsPatients with first-episode schizophrenia experienced intact ‘in-the-moment’ emotion, but their emotion was less predictive of the effort expended, compared with controls. The emotion–behaviour coupling was significantly weaker in patients with schizophrenia with poor working memory than in those with intact working memory. However, compared with controls, patients with intact working also showed substantial emotion–behaviour decoupling.ConclusionsOur findings provide strong evidence for emotion–behaviour decoupling in first-episode schizophrenia. Although working memory deficits contribute to defective translation of liking into effortful behaviour, schizophrenia alone affects emotion–behaviour coupling.

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