THE EFFECT OF SECOND-GENERATION ANTIDEPRESSANT TREATMENT ON THE EXECUTIVE FUNCTIONS OF PATIENTS WITH MAJOR DEPRESSIVE DISORDER: A META-ANALYSIS STUDY WITH STRUCTURAL EQUATION MODELS

Review question / Objective: The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and safety of escitalopram and agomelatine in the major depressive disorder. Condition being studied: Major depressive disorder (MDD), is one of the most common, costly, and disabling mental health conditions worldwide, with an estimated 246 million sufferers globally in 2020.At present, there is a great demand for effective antidepressant treatment in medicine. Information sources: We will search, with no time restrictions, the following databases for relevant English language literature: PubMed, the Cochrane Central Register of Controlled Trials and Web of Science. The search string will be built as follows: (escitalopram) AND (agomelatine) AND (major depressed disorder).

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P-539 - A meta-analysis of executive dysfunctions in unipolar major depressive disorder (MDD) without psychotic symptoms and their changes during antidepressant treatment

European Psychiatry ◽

10.1016/s0924-9338(12)74706-5 ◽

2012 ◽

Vol 27 ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

S. Wagner ◽

I. Helmreich ◽

K. Lieb ◽

A. Tadic

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Antidepressant Treatment ◽

Meta Analysis ◽

Psychotic Symptoms ◽

Major Depressive ◽

Executive Dysfunctions

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The role of peri-traumatic stress and disruption distress in predicting symptoms of major depression following exposure to a natural disaster

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867417691852 ◽

2017 ◽

Vol 51 (7) ◽

pp. 711-718 ◽

Cited By ~ 8

Author(s):

Caroline J Bell ◽

Joseph M Boden ◽

L John Horwood ◽

Roger T Mulder

Keyword(s):

Major Depressive Disorder ◽

Major Depression ◽

Depressive Disorder ◽

Traumatic Stress ◽

Structural Equation ◽

Structural Equation Models ◽

Major Depressive ◽

Symptoms Of Depression ◽

Health And Development

Objective: Few studies have examined the contribution of specific disaster-related experiences to symptoms of depression. The aims of this study were to do this by examining the roles of peri-traumatic stress and distress due to lingering disaster-related disruption in explaining linkages between disaster exposure and major depressive disorder symptoms among a cohort exposed to the 2010–2011 Canterbury (New Zealand) earthquakes. Methods: Structural equation models were fitted to data obtained from the Christchurch Health and Development Study at age 35 ( n = 495), 20–24 months following the onset of the disaster. Measures included earthquake exposure, peri-traumatic stress, disruption distress and symptoms of major depressive disorder. Results: The associations between earthquake exposure and major depression were explained largely by the experience of peri-traumatic stress during the earthquakes (β = 0.180, p < 0.01) and not by disruption distress following the earthquakes (β = 0.048, p = 0.47). Conclusion: The results suggest that peri-traumatic stress has been under-recognised as a predictor of major depressive disorder.

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