Study of the upper energy limit of useful epithermal neutrons for Boron Neutron Capture Therapy in different tissues

2021 ◽  
pp. 109490
Author(s):  
Pablo Torres-Sánchez ◽  
Ignacio Porras ◽  
Fernando Arias de Saavedra ◽  
Javier Praena
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Energy Limit ◽  
Boron Neutron Capture ◽  
Epithermal Neutrons ◽  
Different Tissues

scholarly journals Optimization Problem On Modelling Of Boron Neutron Capture Therapy System

2020 ◽  
pp. 159-164
Author(s):  
Yury Svistunov ◽  
Nikolai Edamenko ◽  
Vassily Gudkov ◽  
Irina Skudnova
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Linear Accelerator ◽  
Optimization Problem ◽  
Comsol Multiphysics ◽  
Neutron Capture Therapy ◽  
Energy Agency ◽  
Boron Neutron Capture ◽  
Epithermal Neutrons ◽  
Physical Optimization

The paper discusses dynamics of charged particles and neutrons in boron neutron capture therapy system (BNCT) as well as geometrical and physical optimization of BNCT system elements. Our choice is BNCT system with linear accelerator. BNCT track includes ion injector, RFQ, DTL, neutron-producing target and neutron moderator which provides an exit (last collimator) flux of epithermal neutrons satisfied to International Atomic Energy Agency (IAEA) requirements. The following software tools IBSimu, LIDOS, COMSOL Multiphysics and PHITS were used for modelling BNCT system.

On the upper limit for the energy of epithermal neutrons for Boron Neutron Capture Therapy

2019 ◽  
Vol 156 ◽  
pp. 240-244 ◽  
Author(s):  
P. Torres-Sánchez ◽  
I. Porras ◽  
F. Arias de Saavedra ◽  
M.P. Sabariego ◽  
J. Praena
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Upper Limit ◽  
Epithermal Neutrons

scholarly journals HGG-05. REGRESSION OF RECURRENT GLIOBLASTOMA AFTER BORON NEUTRON CAPTURE THERAPY AND CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN A CHILD

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii345-iii345
Author(s):  
Hsin-Hung Chen ◽  
Yi-Wei Chen
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chimeric Antigen Receptor ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Antigen Receptor ◽  
Neutron Capture Therapy ◽  
T Cell Therapy ◽  
Boron Neutron Capture ◽  
Car T

Abstract A 6 y/o girl with recurrent multifocal glioblastoma received 3 times of boron neutron capture therapy (BNCT) and chimeric antigen receptor (CAR)–engineered T cells targeting the tumor-associated antigen HER2. Multiple infusions of CAR T cells were administered over 30 days through intraventricular delivery routes. It was not associated with any toxic effects of grade 3 or higher. After BNCT and CAR T-cell treatment, regression of all existing intracranial lesions were observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid, but new lesions recurred soon after the treatment. This clinical response continued for 14 months after the initiation of first recurrence.

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