Sperm parameters and male fertility after bariatric surgery: three case series

Background: The association between migraine and obesity gives the clinician with an exciting possibility to alleviate migraine suffering through weight-reduction gastric-restrictive operations. We hypothesized that bariatric weight-reduction intervention (gastric banding) will be associated with reduction of migraine burden in this population. Methods: A total of 105 women between 18 and 50 years of age, admitted for bariatric surgery between April 2006 and February 2007, were screened for migraine. Twenty-nine with diagnosis of migraine were enrolled into the prospective phase. We followed the migraine pattern of these patients for 6 months post bariatric surgery. Results: Baseline median migraine frequency was six headache days a month. Post bariatric surgery, the migraine-suffering women reported of a lower frequency of migraine attacks ( p < 0.001), shorter duration of the attacks ( p = 0.02), lower medication use during the attack ( p = 0.005), less non-migraine pain (44.8 vs. 33%, p = 0.05), and post-bariatric surgery reduction in headache-related disability assessed by the MIDAS and HIT-6 scores. There was a reduction in migraine frequency among both episodic (from four to one episodes a month) and chronic (from 16.8 to 8.5 episodes per month) migraine patient cohorts separately and combined. Conclusions: Among migraine-suffering premenopausal obese women, we found a reduced frequency of migraine attacks and improvement of headache-related disability post bariatric surgery. Our findings should be interpreted cautiously. The absence of a control group and the non-blinded nature of our small study make it difficult to draw firm conclusions about the causal nature of the headache changes observed in this population. Further study is needed to evaluate the possible specific effects of surgical weight loss on migraine in obese women.

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1338 Bariatric Surgery as a Viable Treatment for Idiopathic Intracranial Hypertension: A Case Series

British Journal of Surgery ◽

10.1093/bjs/znab259.195 ◽

2021 ◽

Vol 108 (Supplement_6) ◽

Author(s):

V Mahendran ◽

P Ricart ◽

M Wadley ◽

A Perry ◽

S Robinson

Keyword(s):

Bariatric Surgery ◽

Weight Loss ◽

Intracranial Hypertension ◽

Idiopathic Intracranial Hypertension ◽

Case Series ◽

Radicular Pain ◽

Csf Pressure ◽

Disease Modifying Therapy ◽

Effective Treatment Modality ◽

Preventable Blindness

Abstract Introduction Idiopathic Intracranial Hypertension (IIH) is a significant cause of preventable blindness. Patients also suffer from debilitating headaches, pulsatile tinnitus, nausea, vomiting, photophobia, and radicular pain. If IIH continues to rise as predicted, treatment cost will increase to 462.7 million GBP annually by 2030. Weight loss is the only proven disease-modifying therapy for reversal of IIH. Bariatric surgery is an attractive treatment option due to superlative weight loss and reversal of related comorbidities. The case series aims to raise awareness of bariatric surgery as a safe and effective treatment modality for IIH. Method The case series consists of a retrospective analysis of four patients with a pre-operative diagnosis of IIH. They were referred to our department for bariatric surgery between January to December 2018. They were followed up for a total of two years. Results In our case series, all four patients were females with a mean age of 34 years. Mean BMI reduced from 47.3 kg/m2 before surgery to 30 kg/m2 with an EWL of 76.4% at the end of two years after surgery. They all showed significant improvement or resolution in their symptoms related to IIH, and none of them required further CSF pressure reducing procedures afterwards. Conclusions Bariatric surgery is a safe and effective method of treating IIH. It is superior compared to medical management and CSF pressure reducing procedures which have high rates of recurrence.

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2064 Favorable Outcomes Among IBD Patients Undergoing Bariatric Surgery: A Case Series

The American Journal of Gastroenterology ◽

10.14309/01.ajg.0000597788.76385.d5 ◽

2019 ◽

Vol 114 (1) ◽

pp. S1154-S1154

Author(s):

Dylan Stanfield ◽

Andrew Spiel ◽

Sumona Saha

Keyword(s):

Bariatric Surgery ◽

Case Series

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Challenges and outcomes for bariatric surgery in patients with paraplegia: Case series and systematic review

Clinical Obesity ◽

10.1111/cob.12382 ◽

2020 ◽

Vol 10 (4) ◽

Author(s):

Georgia R. Layton ◽

Shivam Bhanderi ◽

Mohamed Sahloul ◽

Vasileios Charalampakis ◽

Markos Daskalakis ◽

...

Keyword(s):

Systematic Review ◽

Bariatric Surgery ◽

Case Series

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Mesenteric Panniculitis—First Case Series After Bariatric Surgery

Obesity Surgery ◽

10.1007/s11695-017-3103-x ◽

2018 ◽

Vol 28 (3) ◽

pp. 881-885 ◽

Cited By ~ 1

Author(s):

Amrit Manik Nasta ◽

Dipti Patel ◽

Om Shrivastav ◽

Madhu Goel ◽

Anurag Shrimal ◽

...

Keyword(s):

Bariatric Surgery ◽

Case Series ◽

Mesenteric Panniculitis ◽

First Case

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Environment and Male Fertility: Effects of Benzo-α-Pyrene and Resveratrol on Human Sperm Function In Vitro

Journal of Clinical Medicine ◽

10.3390/jcm8040561 ◽

2019 ◽

Vol 8 (4) ◽

pp. 561 ◽

Cited By ~ 6

Author(s):

Angela Alamo ◽

Rosita A. Condorelli ◽

Laura M. Mongioì ◽

Rossella Cannarella ◽

Filippo Giacone ◽

...

Keyword(s):

Protective Effect ◽

Sperm Motility ◽

Dose Response ◽

Superoxide Anion ◽

Male Fertility ◽

Negative Impact ◽

Sperm Parameters ◽

Mitochondrial Superoxide ◽

Chromatin Compactness

Lifestyle, cigarette smoking and environmental pollution have a negative impact on male fertility. Therefore, the aim of this study was to evaluate the in-vitro effects of benzo-α-pyrene (BaP) and aryl hydrocarbon receptor (AHR) agonists on motility and bio-functional sperm parameters. We further assessed whether resveratrol (RES), an AHR antagonist and antioxidant molecule, had any protective effect. To accomplish this, 30 normozoospermic, healthy, non-smoker men not exposed to BaP were enrolled. Spermatozoa of 15 men were incubated with increasing concentrations of BaP to evaluate its effect and to establish its dose response. Then, spermatozoa of the 15 other men were incubated with BaP (15 µM/mL), chosen according to the dose-response and/or RES to evaluate its antagonistic effects. The effects of both substances were evaluated after 3 h of incubation on total and progressive sperm motility and on the following bio-functional sperm parameters evaluated by flow cytometry: Degree of chromatin compactness, viability, phosphatidylserine externalization (PS), late apoptosis, mitochondrial membrane potential (MMP), DNA fragmentation, degree of lipoperoxidation (LP), and concentrations of mitochondrial superoxide anion. Benzo-α-pyrene decreased total and progressive sperm motility, impaired chromatin compactness, and increased sperm lipoperoxidation and mitochondrial superoxide anion levels. All these effects were statistically significant at the lowest concentration tested (15 µM/mL) and they were confirmed at the concentration of 45 µM/mL. In turn, RES was able to counteract the detrimental effects of BaP on sperm motility, abnormal chromatin compactness, lipid peroxidation, and mitochondrial superoxide. This study showed that BaP alters sperm motility and bio-functional sperm parameters and that RES exerts a protective effect on BaP-induced sperm damage.

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