Treatment of symptomatic uterine adenomyosis with linzagolix, an oral gonadotropin-releasing hormone antagonist: a pilot study

2021 ◽  
Author(s):  
Jacques Donnez ◽  
Olivier Donnez ◽  
Michel Brethous ◽  
Elke Bestel ◽  
Elizabeth Garner ◽  
...  
Keyword(s):  
Pilot Study ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Uterine Adenomyosis

Blood pressure dynamics after pubertal suppression with gonadotropin-releasing hormone analogs followed by estradiol treatment in transgender female adolescents: a pilot study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Liat Perl ◽  
Erella Elkon-Tamir ◽  
Anat Segev-Becker ◽  
Galit Israeli ◽  
Avivit Brener ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pilot Study ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Estrogen Treatment ◽  
Female Adolescents ◽  
Estradiol Treatment ◽  
Releasing Hormone ◽  
Before And After ◽  
Hormone Analogs

Abstract Objectives The benefits of gonadotropin-releasing hormone analogues (GnRHa) in the treatment of central precocious puberty are well established, and their use is regarded as both safe and effective. Possible adverse effects on blood pressure (BP) and cardiac outcomes, body composition, bone health and brain development, however, continue to be of some concern. The aim of this study was to analyze BP changes in transgender female adolescents before and after receiving GnRHa and after adding estrogen treatment. Methods This was a retrospective pilot study. We analyzed systolic BP (SBP) and diastolic BP (DBP) before and after GnRHa initiation and after adding estrogen. Results Nineteen transgender female adolescents received GnRHa and 15 continued to estrogen treatment. Their baseline SBP and DBP percentiles did not change significantly after either GnRHa or the addition of estrogen treatment. Conclusions Blood pressure is apparently not affected by GnRHa or GnRHa + estrogen treatment in transgender female adolescents. Further larger studies are indicated to confirm these findings.

A pilot study of the use of gonadotropin-releasing hormone analog for triggering ovulation

1991 ◽  
Vol 55 (3) ◽  
pp. 644-646 ◽  
Author(s):  
Dan Tulchinsky ◽  
Holly Nash ◽  
Kenneth Brown ◽  
Virginia Paoletti-Falcone ◽  
Janet Polcaro
Keyword(s):  
Pilot Study ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Hormone Analog
Sign in / Sign up

Export Citation Format

Share Document