Polymeric quaternary ammonium salt activity against Fusarium oxysporum f. sp. cubense race 4: Synthesis, structure-activity relationship and mode of action

2017 ◽  
Vol 114 ◽  
pp. 13-22 ◽  
Author(s):  
Zhenfeng Huang ◽  
Runqi Liuyang ◽  
Chengyun Dong ◽  
Yufeng Lei ◽  
Anqiang Zhang ◽  
...  
Keyword(s):  
Fusarium Oxysporum ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Mode Of Action ◽  
Quaternary Ammonium Salt ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Race 4

Triazol: a privileged scaffold for proteolysis targeting chimeras

2019 ◽  
Vol 11 (22) ◽  
pp. 2919-2973 ◽  
Author(s):  
Li-Wen Xia ◽  
Meng-Yu Ba ◽  
Wei Liu ◽  
Weyland Cheng ◽  
Chao-Ping Hu ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Anticancer Activity ◽  
Mode Of Action ◽  
Critical Analysis ◽  
Enzyme Inhibitors ◽  
Structure Activity Relationship ◽  
Target Protein ◽  
Activity Relationship ◽  
Structure Activity ◽  
Privileged Scaffold

Current traditional drugs such as enzyme inhibitors and receptor agonists/antagonists present inherent limitations due to occupancy-driven pharmacology as the mode of action. Proteolysis targeting chimeras (PROTACs) are composed of an E3 ligand, a connecting linker and a target protein ligand, and are an attractive approach to specifically knockdown-targeted proteins utilizing an event-driven mode of action. The length, hydrophilicity and rigidity of connecting linkers play important role in creating a successful PROTAC. Some PROTACs with a triazole linker have displayed promising anticancer activity. This review provides an overview of PROTACs with a triazole scaffold and discusses its structure–activity relationship. Important milestones in the development of PROTACs are addressed and a critical analysis of this drug discovery strategy is also presented.

scholarly journals Antitubercular 2-Pyrazolylpyrimidinones: Structure–Activity Relationship and Mode-of-Action Studies

2021 ◽  
Author(s):  
Candice Soares de Melo ◽  
Vinayak Singh ◽  
Alissa Myrick ◽  
Sandile B. Simelane ◽  
Dale Taylor ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Structure–activity relationship studies of thalidomide analogs with a taxol-like mode of action

2013 ◽  
Vol 23 (24) ◽  
pp. 6902-6904 ◽  
Author(s):  
Bulbul Pandit ◽  
Zhigen Hu ◽  
Somsundaram N. Chettiar ◽  
Jennifer Zink ◽  
Zili Xiao ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Combretastatins: In vitro structure-activity relationship, mode of action and current clinical status

2016 ◽  
Vol 68 (6) ◽  
pp. 1266-1275 ◽  
Author(s):  
Karol Jaroch ◽  
Maciej Karolak ◽  
Przemysław Górski ◽  
Alina Jaroch ◽  
Adrian Krajewski ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Clinical Status ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity
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