Borax mediated synthesis of a biocompatible self-healing hydrogel using dialdehyde carboxymethyl cellulose-dextrin and gelatin

Author(s):  
Amit Kumar Sharma ◽  
Priya ◽  
Balbir Singh Kaith ◽  
Bhagya Shree ◽  
Simran ◽  
...  
2019 ◽  
Vol 10 (30) ◽  
pp. 4106-4115 ◽  
Author(s):  
Gilad Davidson-Rozenfeld ◽  
Lucas Stricker ◽  
Julian Simke ◽  
Michael Fadeev ◽  
Margarita Vázquez-González ◽  
...  

Carboxymethyl cellulose functionalized with nucleic acids, β-cyclodextrin and arylazopyrazole photoisomerizable units self-assembles into stimuli-responsive hydrogels.


Cellulose ◽  
2019 ◽  
Vol 27 (2) ◽  
pp. 853-865 ◽  
Author(s):  
Wei Chen ◽  
Yunhao Bu ◽  
Delin Li ◽  
Chuanjie Liu ◽  
Guangxue Chen ◽  
...  

2021 ◽  
Author(s):  
Amit Kumar Sharma ◽  
Priya Bhalla ◽  
Balbir Singh Kaith ◽  
Bhagya Shree ◽  
Simran Sehgal ◽  
...  

Abstract The hydrogels with self-healing properties have high potential applications in the biomedical field. Generally, the imine bonds are used as the dynamic covalent bonding in the self-healing hydrogels and hydrogen bonding is used for providing additional strength to self-healing hydrogels. In the presented work, Gelatin, dialdehyde dextrin, and dialdehyde Carboxymethyl cellulose (CMC) based hydrogels were prepared which are biocompatible and biodegradable and hence, can be used in biomedical field. Borax and glutaraldehyde were used as binding agent and cross-linker, respectively. The dynamic imide bond formed between gelatin-dialdehyde dextrin, gelatin-dialdehyde CMC, and gelatin-glutaraldehyde were responsible for self-healing ability of the prepared hydrogel. The rheological studies were also carried out which showed that as a consequence of lower viscosity the hydrogels can show injectable properties. The sample was also found to be blood compatible, which further highlights its biomedical importance.


2021 ◽  
Vol 12 (4) ◽  
pp. 4770-4779

Currently, self-healing hydrogels prepared from the green process have been studied for various applications, especially in the biomedical field. This work fabricated the self-healing hydrogel based on sodium carboxymethyl cellulose/poly(vinyl alcohol)/montmorillonite by acidifying the mixture with citric acid. SEM measurements showed well-dispersed montmorillonite in the hydrogels. Cytotoxicity values >100% were seen with montmorillonite added, which indicated cell growth and no cell toxicity. Montmorillonite addition not only reinforced the networks but also improved self-healing ability. The tensile strength of the original uncut hydrogel with montmorillonite (P1C8M1) was 61 kPa, whereas the healed hydrogel showed 57 kPa. The hydrogel healed completely within 10 days, without any cracks, i.e., a 93% healing efficiency, or higher than the ~60% of the non-reinforced hydrogel. This confirmed strong hydrogen bond formation between the polymer and montmorillonite. The self-healing ability of this non-toxic hydrogel, reinforced with montmorillonite, makes it valuable for use in biomedical fields.


Cellulose ◽  
2019 ◽  
Vol 26 (16) ◽  
pp. 8813-8827 ◽  
Author(s):  
Ying Wang ◽  
Guifa Xiao ◽  
Yangyang Peng ◽  
Liheng Chen ◽  
Shiyu Fu

2018 ◽  
Vol 9 (35) ◽  
pp. 7145-7152 ◽  
Author(s):  
Chen Wang ◽  
Michael Fadeev ◽  
Junji Zhang ◽  
Margarita Vázquez-González ◽  
Gilad Davidson-Rozenfeld ◽  
...  

Photoresponsive hydrogels crosslinked by trans-azobenzene/β-cyclodextrin and duplex DNA or K+-G-quadruplex are described. The hydrogels reveal shape-memory functions and self-healing properties.


2017 ◽  
Vol 94 ◽  
pp. 501-510 ◽  
Author(s):  
Yong Mei Chen ◽  
Lei Sun ◽  
Shao An Yang ◽  
Lei Shi ◽  
Wen Jiang Zheng ◽  
...  

2015 ◽  
Vol 72 ◽  
pp. 514-522 ◽  
Author(s):  
Wen Jiang Zheng ◽  
Jie Gao ◽  
Zhao Wei ◽  
Jinxiong Zhou ◽  
Yong Mei Chen

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