scholarly journals Intellectual outcome following childhood severe traumatic brain injury: Results of a prospective longitudinal study: The seven-year follow-up of the TGE cohort

2016 ◽  
Vol 59 ◽  
pp. e132-e133 ◽  
Author(s):  
Mathilde Chevignard ◽  
Leila Francillette ◽  
Hanna Toure ◽  
Dominique Brugel ◽  
Philippe Meyer ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Prospective Longitudinal Study ◽  
Intellectual Outcome ◽  
Prospective Longitudinal

Intellectual Outcome from Preschool Traumatic Brain Injury: A 5-Year Prospective, Longitudinal Study

PEDIATRICS ◽  
2009 ◽  
Vol 124 (6) ◽  
pp. e1064-e1071 ◽  
Author(s):  
V. Anderson ◽  
C. Catroppa ◽  
S. Morse ◽  
F. Haritou ◽  
J. V. Rosenfeld
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Prospective Longitudinal Study ◽  
Intellectual Outcome ◽  
Prospective Longitudinal

scholarly journals Pituitary deficiency and precocious puberty after childhood severe traumatic brain injury: a long-term follow-up prospective study

2019 ◽  
Vol 180 (5) ◽  
pp. 281-290 ◽  
Author(s):  
Yamina Dassa ◽  
Hélène Crosnier ◽  
Mathilde Chevignard ◽  
Magali Viaud ◽  
Claire Personnier ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Height Velocity ◽  
Prospective Longitudinal Study ◽  
Pituitary Dysfunction ◽  
Severe Tbi ◽  
Prospective Longitudinal

Objectives Childhood traumatic brain injury (TBI) is a public health issue. Our objectives were to determine the prevalence of permanent pituitary hormone deficiency and to detect the emergence of other pituitary dysfunctions or central precocious puberty several years after severe TBI. Design Follow-up at least 5 years post severe TBI of a prospective longitudinal study. Patients Overall, 66/87 children, who had endocrine evaluation 1 year post severe TBI, were included (24 with pituitary dysfunction 1 year post TBI). Main outcome measures In all children, the pituitary hormones basal levels were assessed at least 5 years post TBI. Growth hormone (GH) stimulation tests were performed 3–4 years post TBI in children with GH deficiency (GHD) 1 year post TBI and in all children with low height velocity (<−1 DS) or low IGF-1 (<−2 DS). Central precocious puberty (CPP) was confirmed by GnRH stimulation test. Results Overall, 61/66 children were followed up 7 (5–10) years post TBI (median; (range)); 17/61 children had GHD 1 year post TBI, and GHD was confirmed in 5/17 patients. For one boy, with normal pituitary function 1 year post TBI, GHD was diagnosed 6.5 years post TBI. 4/61 patients developed CPP, 5.7 (2.4–6.1) years post-TBI. Having a pituitary dysfunction 1 year post TBI was significantly associated with pituitary dysfunction or CPP more than 5 years post TBI. Conclusion Severe TBI in childhood can lead to permanent pituitary dysfunction; GHD and CPP may appear after many years. We recommend systematic hormonal assessment in children 1 year after severe TBI and a prolonged monitoring of growth and pubertal maturation. Recommendations should be elaborated for the families and treating physicians.

scholarly journals The radiological interpretation of possible microbleeds after moderate or severe traumatic brain injury: a longitudinal study

2021 ◽  
Author(s):  
Anke W. van der Eerden ◽  
Thomas L. A. van den Heuvel ◽  
Marnix C. Maas ◽  
Priya Vart ◽  
Pieter E. Vos ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Time Points ◽  
Computer Aided ◽  
Clinical Consequences ◽  
Severe Tbi ◽  
Over Time

Abstract Introduction In order to augment the certainty of the radiological interpretation of “possible microbleeds” after traumatic brain injury (TBI), we assessed their longitudinal evolution on 3-T SWI in patients with moderate/severe TBI. Methods Standardized 3-T SWI and T1-weighted imaging were obtained 3 and 26 weeks after TBI in 31 patients. Their microbleeds were computer-aided detected and classified by a neuroradiologist as no, possible, or definite at baseline and follow-up, separately (single-scan evaluation). Thereafter, the classifications were re-evaluated after comparison between the time-points (post-comparison evaluation). We selected the possible microbleeds at baseline at single-scan evaluation and recorded their post-comparison classification at follow-up. Results Of the 1038 microbleeds at baseline, 173 were possible microbleeds. Of these, 53.8% corresponded to no microbleed at follow-up. At follow-up, 30.6% were possible and 15.6% were definite. Of the 120 differences between baseline and follow-up, 10% showed evidence of a pathophysiological change over time. Proximity to extra-axial injury and proximity to definite microbleeds were independently predictive of becoming a definite microbleed at follow-up. The reclassification level differed between anatomical locations. Conclusions Our findings support disregarding possible microbleeds in the absence of clinical consequences. In selected cases, however, a follow-up SWI-scan could be considered to exclude evolution into a definite microbleed.

Mild traumatic brain injury and fatigue: A prospective longitudinal study

Brain Injury ◽  
2010 ◽  
Vol 24 (13-14) ◽  
pp. 1528-1538 ◽  
Author(s):  
Joan Norrie ◽  
Marcus Heitger ◽  
Janet Leathem ◽  
Tim Anderson ◽  
Richard Jones ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

scholarly journals Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e042093
Author(s):  
Neil Samuel Nyholm Graham ◽  
Karl A Zimmerman ◽  
Guido Bertolini ◽  
Sandra Magnoni ◽  
Mauro Oddo ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Ethics Committee ◽  
Cerebral Microdialysis ◽  
Prospective Longitudinal Study ◽  
Neuroimaging Biomarkers ◽  
Prospective Longitudinal

Introduction and aimsTraumatic brain injury (TBI) often results in persistent disability, due particularly to cognitive impairments. Outcomes remain difficult to predict but appear to relate to axonal injury. Several new approaches involving fluid and neuroimaging biomarkers show promise to sensitively quantify axonal injury. By assessing these longitudinally in a large cohort, we aim both to improve our understanding of the pathophysiology of TBI, and provide better tools to predict clinical outcome.Methods and analysisBIOmarkers of AXonal injury after TBI is a prospective longitudinal study of fluid and neuroimaging biomarkers of axonal injury after moderate-to-severe TBI, currently being conducted across multiple European centres. We will provide a detailed characterisation of axonal injury after TBI, using fluid (such as plasma/microdialysate neurofilament light) and neuroimaging biomarkers (including diffusion tensor MRI), which will then be related to detailed clinical, cognitive and functional outcome measures. We aim to recruit at least 250 patients, including 40 with cerebral microdialysis performed, with serial assessments performed twice in the first 10 days after injury, subacutely at 10 days to 6 weeks, at 6 and 12 months after injury.Ethics and disseminationThe relevant ethical approvals have been granted by the following ethics committees: in London, by the Camberwell St Giles Research Ethics Committee; in Policlinico (Milan), by the Comitato Etico Milano Area 2; in Niguarda (Milan), by the Comitato Etico Milano Area 3; in Careggi (Florence), by the Comitato Etico Regionale per la Sperimentazione Clinica della Regione Toscana, Sezione area vasta centro; in Trento, by the Trento Comitato Etico per le Sperimentazioni Cliniche, Azienda Provinciale per i Servizi Sanitari della Provincia autonoma di Trento; in Lausanne, by the Commission cantonale d’éthique de la recherche sur l’être humain; in Ljubljana, by the National Medical Ethics Committee at the Ministry of Health of the Republic of Slovenia. The study findings will be disseminated to patients, healthcare professionals, academics and policy-makers including through presentation at conferences and peer-reviewed publications. Data will be shared with approved researchers to provide further insights for patient benefit.Trial registration numberNCT03534154.

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