Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells

2008 ◽  
Vol 25 (4) ◽  
pp. 447-454 ◽  
Author(s):  
Palaniappan Murugesan ◽  
Thirupathi Muthusamy ◽  
Karundevi Balasubramanian ◽  
Jagadeesan Arunakaran
Keyword(s):  
Antioxidant Enzymes ◽  
Leydig Cells ◽  
Polychlorinated Biphenyl ◽  
Aroclor 1254 ◽  
Testosterone Biosynthesis

Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells

Toxicology ◽  
2007 ◽  
Vol 232 (3) ◽  
pp. 170-182 ◽  
Author(s):  
Palaniappan Murugesan ◽  
Thirupathi Muthusamy ◽  
Karundevi Balasubramanian ◽  
Jagadeesan Arunakaran
Keyword(s):  
Mrna Expression ◽  
Leydig Cells ◽  
Polychlorinated Biphenyl ◽  
Steroidogenic Enzymes ◽  
Aroclor 1254 ◽  
Adult Rat

Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)—induced oxidative damage in Leydig cells

2005 ◽  
Vol 39 (11) ◽  
pp. 1259-1272 ◽  
Author(s):  
Palaniappan Murugesan ◽  
Thirupathi Muthusamy ◽  
Karundevi Balasubramanian ◽  
Jagadeesan Arunakaran
Keyword(s):  
Vitamin C ◽  
Oxidative Damage ◽  
Leydig Cells ◽  
Polychlorinated Biphenyl ◽  
Protective Role ◽  
Aroclor 1254

The inhibitory effects of polychlorinated biphenyl Aroclor 1254 on Leydig cell LH receptors, steroidogenic enzymes and antioxidant enzymes in adult rats

2005 ◽  
Vol 20 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Palaniappan Murugesan ◽  
Palaniyandi Kanagaraj ◽  
Sambandam Yuvaraj ◽  
Karundevi Balasubramanian ◽  
Maria Michael Aruldhas ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Leydig Cell ◽  
Polychlorinated Biphenyl ◽  
Inhibitory Effects ◽  
Steroidogenic Enzymes ◽  
Aroclor 1254 ◽  
Adult Rats

Reproductive and Thyroid Effects of Low-Level Polychlorinated Biphenyl (Aroclor 1254) Exposure

1993 ◽  
Vol 20 (3) ◽  
pp. 288-294 ◽  
Author(s):  
L. EARL GRAY ◽  
J. OSTBY ◽  
R. MARSHALL ◽  
J. ANDREWS
Keyword(s):  
Polychlorinated Biphenyl ◽  
Aroclor 1254 ◽  
Low Level

A comparative study of the action of several lutropin derivatives on rat Leydig cells

1980 ◽  
Vol 93 (2) ◽  
pp. 250-256 ◽  
Author(s):  
M. P. de la Llosa-Hermier ◽  
C. Tertrin-Clary ◽  
M. Evrard-Herouard ◽  
Y. Colleaux ◽  
C. Hermier ◽  
...  
Keyword(s):  
Leydig Cells ◽  
Binding Activity ◽  
Camp Accumulation ◽  
Lh Receptor ◽  
Testosterone Production ◽  
Receptor Assay ◽  
Testosterone Biosynthesis ◽  
Radioligand Receptor Assay ◽  
Relative Potencies ◽  
Good Agreement

Abstract. Rat intestinal cells prepared from testes were incubated in the presence of different lutropin derivatives obtained by chemical modification of the amino groups. The cAMP accumulation and the testosterone biosynthesis were determined in the cell homogenates. Binding determinations were carried out by a radioligand receptor assay using tritiated methylated lutropin. The binding activities — relative to native LH — of three different derivatives obtained by reductive alkylation (methylated, ethylated and isopropylated LH) were in good agreement with the relative potencies assessed by their capacity to stimulate cAMP and testosterone production. Guanidinated LH (11 — NH2 groups modified) exhibited a binding activity and a relative potency relatively high with regard to cAMP accumulation (as compared with that of native LH). Its steroidogenic potency, however, was very low. When Leydig cells were incubated in the presence of native and guanidinated LH, the testosterone production was similar to that induced by the derivative alone, indicating that the derivative exerted a competitive inhibitory action preventing the stimulation of steroidogenesis by native LH. These results suggest that a guanidinated derivative is able to bind to the LH receptor and the complex so formed is able to be coupled with an adenylate cyclase pool (or cAMP compartment) which is not connected with the steroidogenic pathway.

Biphasic effects of octylphenol on testosterone biosynthesis by cultured Leydig cells from neonatal rats

1999 ◽  
Vol 13 (6) ◽  
pp. 451-462 ◽  
Author(s):  
Eisuke P Murono ◽  
Raymond C Derk ◽  
Jesús H de León
Keyword(s):  
Leydig Cells ◽  
Neonatal Rats ◽  
Testosterone Biosynthesis

scholarly journals Expression pattern and potential role of Nanos3 in regulating testosterone biosynthesis in Leydig cells of sheep

2020 ◽  
Vol 154 ◽  
pp. 31-42
Author(s):  
Jie Zhao ◽  
Hua Yang ◽  
Mingtian Deng ◽  
Jianyu Ma ◽  
Zhibo Wang ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Leydig Cells ◽  
Potential Role ◽  
Testosterone Biosynthesis
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