A case report on management of severe childhood pneumonia in low resource settings

Background. Cellular primary immunodeficiencies are rarely reported from Africa. DiGeorge syndrome is a commonly recognized form of a congenital T-cell deficiency. The disorder is characterized by hypoplastic or aplastic thymus, hypocalcemia, recurrent infections, and other associated congenital defects. Case Report. We report an eleven-month-old infant presenting with recurrent chest and diarrheal infections, failure to thrive, lymphopenia, hypocalcemia, and hypoplastic thymus on imaging. A diagnosis of DiGeorge syndrome was confirmed after determining very low CD3 and CD4 levels. Conclusions. We describe the first case report of an Ethiopian child with a congenital T-cell immunodeficiency. We have outlined essentials for diagnosis and management of cellular primary immunodeficiency disorders in low resource settings.

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mPneumonia, an Innovation for Diagnosing and Treating Childhood Pneumonia in Low-Resource Settings: A Feasibility, Usability and Acceptability Study in Ghana

PLoS ONE ◽

10.1371/journal.pone.0165201 ◽

2016 ◽

Vol 11 (10) ◽

pp. e0165201 ◽

Cited By ~ 11

Author(s):

Amy Sarah Ginsburg ◽

Charlotte Tawiah Agyemang ◽

Gwen Ambler ◽

Jaclyn Delarosa ◽

Waylon Brunette ◽

...

Keyword(s):

Low Resource Settings ◽

Childhood Pneumonia ◽

Low Resource

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Sudden cardiac death in low-resource settings: lessons from a resuscitated cardiac arrest: case report

CardioVascular Journal of Africa ◽

10.5830/cvja-2015-020 ◽

2015 ◽

Vol 26 (2) ◽

pp. 91-95 ◽

Cited By ~ 2

Author(s):

A Bonny ◽

SN Amougou ◽

M-L Mbenoun ◽

K Karaye

Keyword(s):

Cardiac Arrest ◽

Case Report ◽

Sudden Cardiac Death ◽

Cardiac Death ◽

Low Resource Settings ◽

Low Resource

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Initial Limb Salvage Intervention for a Mangled Lower Extremity in a Four-Year-Old Male: A Case Report of the Alternatives in Low-resource Settings

Journal of Kermanshah University of Medical Sciences ◽

10.5812/jkums.106725 ◽

2021 ◽

Vol 25 (3) ◽

Author(s):

Kofi Tawiah Mensah

Keyword(s):

Case Report ◽

Limb Salvage ◽

Low Resource Settings ◽

Low Resource ◽

The Road ◽

Mangled Extremity ◽

Successful Case ◽

Severity Scores ◽

Emergency Units ◽

Extremity Injuries

Introduction: Mangled extremity injuries in civilian settings are challenging conditions for the accident and emergency units of low-resource settings where salvage therapies may not be feasible or affordable for the patients. Case Report: We have described a successful case of initial conservative limb salvage management for a mangled distal left lower limb in a four-year-old male who sustained the injury when a vehicle ran over his extremity as he played by the road. The treatment approach was in contrast to the radical completion of amputation with its attendant revisions, which are associated with similar injuries with the mangled extremity severity scores of ≥ 7. Conclusions: The benefits and challenges of the limb salvage intervention were discussed based on the literature in this regard, and a recommendation was proposed while considering an initial conservative limb salvage approach in well-resuscitated children presenting early with a mangled extremity injury.

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Multicentre pilot study evaluation of lung ultrasound for the management of paediatric pneumonia in low-resource settings: a study protocol

BMJ Open Respiratory Research ◽

10.1136/bmjresp-2018-000340 ◽

2018 ◽

Vol 5 (1) ◽

pp. e000340 ◽

Cited By ~ 3

Author(s):

Jennifer L Lenahan ◽

Giovanni Volpicelli ◽

Alessandro Lamorte ◽

Fyezah Jehan ◽

Quique Bassat ◽

...

Keyword(s):

Lung Ultrasound ◽

Integrated Management ◽

Healthcare Providers ◽

World Health ◽

Phone Call ◽

Low Resource Settings ◽

Childhood Pneumonia ◽

Low Resource ◽

Study Results ◽

Health Organization

IntroductionPneumonia is the leading infectious cause of death among children under 5 years of age worldwide. However, pneumonia is challenging to diagnose. Lung ultrasound (LUS) is a promising diagnostic technology. Further evidence is needed to better understand the role of LUS as a tool for the diagnosis of childhood pneumonia in low-resource settings.Methods and analysisThis study aims to pilot LUS in Mozambique and Pakistan and to generate evidence regarding the use of LUS as a diagnostic tool for childhood pneumonia. Children with cough <14 days with chest indrawing (n=230) and without chest indrawing (n=40) are enrolled. World Health Organization Integrated Management of Childhood Illness assessment is performed at enrolment, along with a chest radiograph and LUS examination. Respiratory and blood specimens are collected for viral and bacterial testing and biomarker assessment. Enrolled children are followed for 14 days (in person) and 30 days (phone call) post-enrolment with LUS examinations performed on Days 2, 6 and 14. Qualitative and quantitative data are also collected to assess feasibility, usability and acceptability of LUS among healthcare providers and caregivers. The primary outcome is LUS findings at enrolment with secondary outcomes including patient outcomes, repeat LUS findings, viral and bacterial test results, and patient status after 14 and 30 days of follow-up.Ethics and disseminationThis trial was approved by the Western Institutional Review Board as well as local ethics review committees at each site. We plan to disseminate study results in peer-reviewed journals and international conferences.Trial registration numberNCT03187067.

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