scholarly journals Review of carbon ion radiotherapy for skull base tumors (especially chordomas)

2016 ◽  
Vol 21 (4) ◽  
pp. 356-360 ◽  
Author(s):  
Jun-etsu Mizoe
2012 ◽  
Vol 103 ◽  
pp. S410-S411
Author(s):  
M. Koto ◽  
A. Hasegawa ◽  
R. Takagi ◽  
A. Fujikawa ◽  
T. Morikawa ◽  
...  

2014 ◽  
Vol 111 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Masashi Koto ◽  
Azusa Hasegawa ◽  
Ryo Takagi ◽  
Akira Fujikawa ◽  
Takamichi Morikawa ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 339
Author(s):  
Giulia Buizza ◽  
Chiara Paganelli ◽  
Emma D’Ippolito ◽  
Giulia Fontana ◽  
Silvia Molinelli ◽  
...  

Skull-base chordoma (SBC) can be treated with carbon ion radiotherapy (CIRT) to improve local control (LC). The study aimed to explore the role of multi-parametric radiomic, dosiomic and clinical features as prognostic factors for LC in SBC patients undergoing CIRT. Before CIRT, 57 patients underwent MR and CT imaging, from which tumour contours and dose maps were obtained. MRI and CT-based radiomic, and dosiomic features were selected and fed to two survival models, singularly or by combining them with clinical factors. Adverse LC was given by in-field recurrence or tumour progression. The dataset was split in development and test sets and the models’ performance evaluated using the concordance index (C-index). Patients were then assigned a low- or high-risk score. Survival curves were estimated, and risk groups compared through log-rank tests (after Bonferroni correction α = 0.0083). The best performing models were built on features describing tumour shape and dosiomic heterogeneity (median/interquartile range validation C-index: 0.80/024 and 0.79/0.26), followed by combined (0.73/0.30 and 0.75/0.27) and CT-based models (0.77/0.24 and 0.64/0.28). Dosiomic and combined models could consistently stratify patients in two significantly different groups. Dosiomic and multi-parametric radiomic features showed to be promising prognostic factors for LC in SBC treated with CIRT.


Cancer ◽  
2009 ◽  
Vol 115 (6) ◽  
pp. 1348-1355 ◽  
Author(s):  
Stephanie E. Combs ◽  
Anna Nikoghosyan ◽  
Oliver Jaekel ◽  
Christian P. Karger ◽  
Thomas Haberer ◽  
...  

2018 ◽  
Vol 20 (suppl_3) ◽  
pp. iii311-iii312
Author(s):  
A Iannalfi ◽  
E D’Ippolito ◽  
V Vitolo ◽  
B Vischioni ◽  
M Fiore ◽  
...  

2019 ◽  
Vol 133 ◽  
pp. S368
Author(s):  
A. Iannalfi ◽  
E. D’Ippolito ◽  
V. Vitolo ◽  
B. Vischioni ◽  
M.R. Fiore ◽  
...  

2013 ◽  
Vol 52 (7) ◽  
pp. 1504-1509 ◽  
Author(s):  
Stephanie E. Combs ◽  
Kerstin Kessel ◽  
Daniel Habermehl ◽  
Thomas Haberer ◽  
Oliver Jäkel ◽  
...  

Head & Neck ◽  
2020 ◽  
Vol 42 (9) ◽  
pp. 2607-2613 ◽  
Author(s):  
Masashi Koto ◽  
Hiroaki Ikawa ◽  
Takashi Kaneko ◽  
Yasuhito Hagiwara ◽  
Kazuhiko Hayashi ◽  
...  

2003 ◽  
Vol 179 (9) ◽  
pp. 598-605 ◽  
Author(s):  
Daniela Schulz-Ertner ◽  
Anna Nikoghosyan ◽  
Christoph Thilmann ◽  
Thomas Haberer ◽  
Oliver Jäkel ◽  
...  

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