In vitro DNA and BSA-binding, cell imaging and anticancer activity against human carcinoma cell lines of mixed ligand copper(II) complexes

Author(s):  
Marzieh Anjomshoa ◽  
Masoud Torkzadeh-Mahani
2017 ◽  
Vol 454 ◽  
pp. 184-196 ◽  
Author(s):  
Roya Esteghamat-Panah ◽  
Hassan Hadadzadeh ◽  
Hossein Farrokhpour ◽  
Maryam Mortazavi ◽  
Zahra Amirghofran

2019 ◽  
Vol 16 (6) ◽  
pp. 663-669
Author(s):  
Dan Liu ◽  
Aiqi Xue ◽  
Zhixin Liu ◽  
Yi Zhang ◽  
Penghui Peng ◽  
...  

Background: Three series of new 7-fluoro-4-(1-piperazinyl) quinolines (I1~I6, II1~II2 and IV1~IV4) were synthesized. Their anti-tumor activity was evaluated in vitro against three human carcinoma cell lines, namely SGC-7901 cells, BEL-7402 cells and A549 cells expressing high levels of EGFR by Methyl Thiazolyl Terazolium (MTT) assay. Methods: Three series of quinoline derivatives were synthesized, characterized and evaluated for their in vitro anti-tumor activities. Results and Discussion: Structures of the newly synthesized compounds were confirmed by spectral analysis. The preliminary bioassay indicated that compounds I1, I10 and II1 exhibited better anti-tumor activity than the rest of the target compounds and gefitinib against A549 cell based assay, which demonstrated that compounds I1, I10 and II1 are potential agents for cancer therapy. Results suggested that the substitutes on piperazinyl influenced anti-tumor activities remarkably. Conclusion: These results are useful for discovering more potent novel anti-tumor compounds and further studies are ongoing.


1996 ◽  
Vol 16 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Elisa A. Spillare ◽  
Aikou Okamoto ◽  
Koichi Hagiwara ◽  
Douglas J. Demetrick ◽  
Manuel Serrano ◽  
...  

2019 ◽  
Vol 24 (6) ◽  
pp. 937-944 ◽  
Author(s):  
SAHIBZADA SHAKIR REHMAN ◽  
◽  
AISHA ASHRAF ◽  
ZILL-I-HUMA NAZLI ◽  
ABIDA KAUSAR ◽  
...  

2009 ◽  
Vol 44 (6) ◽  
pp. 2736-2740 ◽  
Author(s):  
Sau Hing Chan ◽  
Kim Hung Lam ◽  
Chung Hin Chui ◽  
Roberto Gambari ◽  
Marcus Chun Wah Yuen ◽  
...  

2017 ◽  
Vol 111 ◽  
pp. 37-43 ◽  
Author(s):  
V. Kuete ◽  
F.L. Dongmo Mafodong ◽  
I. Celik ◽  
S.A.T. Fobofou ◽  
B.L. Ndontsa ◽  
...  

1996 ◽  
Vol 37 (6) ◽  
pp. 525-530 ◽  
Author(s):  
Y. Kano ◽  
Miyuki Akutsu ◽  
Saburo Tsunoda ◽  
Kenichi Suzuki ◽  
Yasuo Yazawa

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Kok Kwan Tan ◽  
Tracey D Bradshaw ◽  
Jessica Chu ◽  
Teng Jin Khoo ◽  
Christophe Wiart

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