Persistent negative symptoms after first episode schizophrenia: A 2-year follow-up study

BackgroundThe outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date.MethodWe conducted a first-episode follow-up study of 97 patients with DSM-IV schizophrenia over the first 4 years of illness. First presentation and follow-up assessments were compared using paired t tests and a forced-entry regression analysis was used to determine prognostic variables.ResultsThere were significant improvements in positive and negative symptoms and global assessment of functioning between first presentation and follow-up. At first presentation, fewer negative symptoms (t=−3.40, p<0.01), more years spent in education (t=3.25, p<0.01), and a shorter duration of untreated psychosis (DUP) (t=−2.77, p<0.01) significantly predicted a better outcome at follow-up.ConclusionsThe outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness. This study supports the relationship between DUP and outcome beyond the early stages of illness.

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Cognitive functioning in patients with first-episode psychosis stratified by level of negative symptoms: A 1-year follow-up study

Psychiatry Research ◽

10.1016/j.psychres.2019.112554 ◽

2019 ◽

Vol 281 ◽

pp. 112554 ◽

Cited By ~ 1

Author(s):

Magnus Johan Engen ◽

Carmen Simonsen ◽

Ingrid Melle ◽

Ann Færden ◽

Siv Hege Lyngstad ◽

...

Keyword(s):

Cognitive Functioning ◽

Negative Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Follow Up Study ◽

Episode Psychosis

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Resting-state functional connectivity of the striatum predicts improvement in negative symptoms and general functioning in patients with first-episode psychosis: A 1-year naturalistic follow-up study

IBRO Reports ◽

10.1016/j.ibror.2019.07.1458 ◽

2019 ◽

Vol 6 ◽

pp. S462-S463

Author(s):

Sanghoon Oh ◽

Minah Kim ◽

Tae Young Lee ◽

Taekwan Kim ◽

Jun Soo Kwon

Keyword(s):

Functional Connectivity ◽

Resting State ◽

Negative Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Resting State Functional Connectivity ◽

Follow Up Study ◽

Episode Psychosis ◽

General Functioning

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Poster #M169 PERSISTANT NEGATIVE SYMPTOMS AFTER FIRST-EPISODE SCHIZOPHRENIA; RESULTS OF 2 YEARS FOLLOW-UP

Schizophrenia Research ◽

10.1016/s0920-9964(14)70719-4 ◽

2014 ◽

Vol 153 ◽

pp. S252

Author(s):

Alp Üçok ◽

Ceylan Ergül

Keyword(s):

Negative Symptoms ◽

First Episode ◽

First Episode Schizophrenia

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Predictors of Remission and Recovery in a First-Episode Schizophrenia Spectrum Disorder Sample: 2-Year Follow-up of the OPUS Trial

The Canadian Journal of Psychiatry ◽

10.1177/070674370805301005 ◽

2008 ◽

Vol 53 (10) ◽

pp. 660-670 ◽

Cited By ~ 61

Author(s):

Lone Petersen ◽

Anne Thorup ◽

Johan Øqhlenschlæger ◽

Torben Øqstergaard Christensen ◽

Pia Jeppesen ◽

...

Keyword(s):

Substance Abuse ◽

Negative Symptoms ◽

Spectrum Disorder ◽

First Episode ◽

Schizophrenia Spectrum Disorder ◽

Adherence To Medication ◽

Premorbid Adjustment ◽

Schizophrenia Spectrum ◽

First Episode Schizophrenia

Objective: To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD). Method: We conducted a 2-year follow-up of a cohort of patients ( n = 547) with first-episode SSD. We evaluated the patients on demographic variables, diagnosis, duration of untreated psychosis (DUP), premorbid functioning, psychotic and negative symptoms, substance abuse, adherence to medication, and service use. ORs were calculated with logistic regression analyses. Results: A total of 369 patients (67%) participated in the follow-up interview. After 2 years, 36% remitted and 17% were considered fully recovered. Full recovery was associated with shorter DUP, better premorbid adjustment, fewer negative symptoms at baseline, no substance abuse at baseline, and adherence to medication and OPUS treatment. Conclusions: Several predictive factors were identified, and focus should be on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome, for example, patients with a substance abuse problem and poor premorbid adjustment.

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