Test-retest reliability of mismatch negativity and gamma-band auditory steady-state response in patients with schizophrenia

2022 ◽  
Vol 240 ◽  
pp. 165-174
Author(s):  
Xiong Jiao ◽  
Qiang Hu ◽  
Yingying Tang ◽  
Zhenying Qian ◽  
Shanbao Tong ◽  
...  
2017 ◽  
Vol 114 ◽  
pp. 16-23 ◽  
Author(s):  
Kristina T. Legget ◽  
Allison K. Hild ◽  
Sarah E. Steinmetz ◽  
Steven T. Simon ◽  
Donald C. Rojas

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85748 ◽  
Author(s):  
Kristina L. McFadden ◽  
Sarah E. Steinmetz ◽  
Adam M. Carroll ◽  
Steven T. Simon ◽  
Alissa Wallace ◽  
...  

2007 ◽  
Vol 420 (3) ◽  
pp. 223-228 ◽  
Author(s):  
Patrick D. Skosnik ◽  
Giri P. Krishnan ◽  
Brian F. O’Donnell

2010 ◽  
Vol 1 ◽  
pp. 40
Author(s):  
Jessamy Sara Norton-Ford ◽  
Siyi Deng ◽  
Ramesh Srinivasan ◽  
Mary Louise Kean

Recent work has found differences in lateralization of gamma band auditory steady state response power (?-aSSR) in temporo-parietal areas to speech vs. non-speech stim- uli, based on differences in “meaningfulness” (Deng & Srinivasan, 2009). To investigate sensitivity of ?-aSSR to linguistic features of a stimulus, EEG data was collected from six participants in response to 40Hz amplitude-modulated speech, jabberwocky, reversed speech and spectrally-rotated (“unintelligible”) speech. Significance tests were conducted for the four conditions, within and across-hemisphere. Additionally, correlational analysis of stimulus speech envelope and EEG output will be conducted. Initial results indicate overall right-lateralization, and additional left-hemisphere distinction by condition.


PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0193422 ◽  
Author(s):  
Yoshiaki Miyagishi ◽  
Takashi Ikeda ◽  
Tetsuya Takahashi ◽  
Kiwamu Kudo ◽  
Hirofumi Morise ◽  
...  

2020 ◽  
Vol 35 (1) ◽  
pp. 15-22
Author(s):  
James Gilleen ◽  
Judith Nottage ◽  
Farah Yakub ◽  
Sarah Kerins ◽  
Lorena Valdearenas ◽  
...  

Background: Patients with schizophrenia have significant cognitive deficits, which may profoundly impair quality of life. These deficits are also evident at the neurophysiological level with patients demonstrating altered event-related potential in several stages of cognitive processing compared to healthy controls; within the auditory domain, for example, there are replicated alterations in Mismatch Negativity, P300 and Auditory Steady State Response. However, there are no approved pharmacological treatments for cognitive deficits in schizophrenia. Aims: Here we examine whether the phosphodiesterase-4 inhibitor, roflumilast, can improve neurophysiological deficits in schizophrenia. Methods: Using a randomised, double-blind, placebo-controlled, crossover design study in 18 patients with schizophrenia, the effect of the phosphodiesterase-4 inhibitor, roflumilast (100 µg and 250 µg) on auditory steady state response (early stage), mismatch negativity and theta (intermediate stage) and P300 (late stage) was examined using electroencephalogram. A total of 18 subjects were randomised and included in the analysis. Results: Roflumilast 250 µg significantly enhanced the amplitude of both the mismatch negativity ( p=0.04) and working memory-related theta oscillations ( p=0.02) compared to placebo but not in the other (early- or late-stage) cognitive markers. Conclusions: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage. This study also underlines the use of neurophysiological measures as cognitive biomarkers in experimental medicine.


2019 ◽  
Vol 208 ◽  
pp. 467-469 ◽  
Author(s):  
Daisuke Koshiyama ◽  
Kenji Kirihara ◽  
Mariko Tada ◽  
Tatsuya Nagai ◽  
Mao Fujioka ◽  
...  

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