Comparative liver accumulation of dioxin-like compounds in sheep and cattle: Possible role of AhR-mediated xenobiotic metabolizing enzymes

2016 ◽  
Vol 571 ◽  
pp. 1222-1229 ◽  
Author(s):  
F. Girolami ◽  
V. Spalenza ◽  
A. Benedetto ◽  
L. Manzini ◽  
P. Badino ◽  
...  
Keyword(s):  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes

The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: Functional and localization studies

1997 ◽  
Vol 376 (1-2) ◽  
pp. 153-160 ◽  
Author(s):  
Kelly F Windmill ◽  
Ross A McKinnon ◽  
Xiaoyi Zhu ◽  
Andrea Gaedigk ◽  
Denis M Grant ◽  
...  
Keyword(s):  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes

The Role of Xenobiotic-Metabolizing Enzymes in Anthelmintic Deactivation and Resistance in Helminths

2016 ◽  
Vol 32 (6) ◽  
pp. 481-491 ◽  
Author(s):  
Petra Matoušková ◽  
Ivan Vokřál ◽  
Jiří Lamka ◽  
Lenka Skálová
Keyword(s):  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes

The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field

2020 ◽  
Vol 13 (3) ◽  
pp. 247-263 ◽  
Author(s):  
Ricardo Blanco-Castañeda ◽  
Carlos Galaviz-Hernández ◽  
Paula C. S. Souto ◽  
Victor Vitorino Lima ◽  
Fernanda R. Giachini ◽  
...  
Keyword(s):  
Research Field ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes

Chemical Metabolism of Xenobiotics by Gut Microbiota

2020 ◽  
Vol 21 (4) ◽  
pp. 260-269
Author(s):  
Radislav Nakov ◽  
Tsvetelina Velikova
Keyword(s):  
Gut Microbiota ◽  
Xenobiotic Metabolism ◽  
Human Biology ◽  
Herbal Supplements ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Chemical Structures ◽  
Growing Body ◽  
Metabolism Of Xenobiotics

: Among the gut microbiota’s newly explored roles in human biology is the ability to modify the chemical structures of foreign compounds (xenobiotics). A growing body of evidence has now provided sufficient acumen on the role of the gut microbiota on xenobiotic metabolism, which could have an intense impact on the therapy for various diseases in the future. Gut microbial xenobiotic metabolites have altered bioavailability, bioactivity and toxicity and can intervene with the actions of human xenobiotic-metabolizing enzymes to affect the destiny of other ingested molecules. These modifications are diverse and could lead to physiologically important consequences. : In the current manuscript we aim to review the data currently available on how the gut microbiota directly modifies drugs, dietary compounds, chemicals, pollutants, pesticides and herbal supplements.

STEROID HORMONE METABOLISM IN RESPONSIVE TISSUES IN VITRO

1971 ◽  
Vol 68 (1_Suppl) ◽  
pp. S279-S294 ◽  
Author(s):  
Paul Robel
Keyword(s):  
Steroid Hormone ◽  
Physiological Activity ◽  
Physiological State ◽  
Target Cells ◽  
Target Tissue ◽  
Hormone Metabolism ◽  
Metabolizing Enzymes ◽  
Relationship Of

ABSTRACT Of the information available on steroid hormone metabolism in responsive tissues, only that relating hormone metabolism to physiological activity is reviewed, i. e. metabolite activity in isolated in vitro systems, binding of metabolites to target tissue receptors, specific steroid hormone metabolizing enzymes and relationship of hormone metabolism to target organ physiological state. Further, evidence is presented in the androgen field, demonstrating 5α-reduced metabolites, formed inside the target cells, as active compounds. This has led to a consideration of testosterone as a »prehormone«. The possibility that similar events take place in tissues responding to progesterone is discussed. Finally, the role of hormone metabolism in the regulation of hormone availability and/or renewal in target cells is discussed. In this context, reference is made to the potential role of plasma binding proteins and cytosol receptors.

Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers

2019 ◽  
Vol 130 ◽  
pp. 32-43 ◽  
Author(s):  
Elias Begas ◽  
Maria Bounitsi ◽  
Thomas Kilindris ◽  
Evangelos Kouvaras ◽  
Konstantinos Makaritsis ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Crocus Sativus ◽  
Short Term ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Crocus Sativus L
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