Chronic exposure to dietary antibiotics affects intestinal health and antibiotic resistance gene abundance in oriental river prawn (Macrobrachium nipponense), and provokes human health risk

2020 ◽  
Vol 720 ◽  
pp. 137478 ◽  
Author(s):  
Shengming Sun ◽  
Dominic K.A. Korheina ◽  
Hongtuo Fu ◽  
Xianping Ge
Keyword(s):  
Antibiotic Resistance ◽  
Health Risk ◽  
Human Health ◽  
Resistance Gene ◽  
Chronic Exposure ◽  
Antibiotic Resistance Gene ◽  
Human Health Risk ◽  
Intestinal Health ◽  
Macrobrachium Nipponense ◽  
Oriental River Prawn

scholarly journals Deep analysis and optimization of CARD antibiotic resistance gene discovery models

BMC Genomics ◽  
2019 ◽  
Vol 20 (S10) ◽  
Author(s):  
Haobin Yao ◽  
Siu-Ming Yiu
Keyword(s):  
Antibiotic Resistance ◽  
Human Health ◽  
Resistance Gene ◽  
Decision Model ◽  
Antibiotic Resistance Gene ◽  
Gene Discovery ◽  
Antibiotic Resistance Genes ◽  
Optimization Method ◽  
Depth Analysis ◽  
Card Model

Abstract Background Identification of antibiotic resistance genes from environmental samples has been a critical sub-domain of gene discovery which is directly connected to human health. However, it is drawing extraordinary attention in recent years and regarded as a severe threat to human health by many institutions around the world. To satisfy the needs for efficient ARG discovery, a series of online antibiotic resistance gene databases have been published. This article will conduct an in-depth analysis of CARD, one of the most widely used ARG databases. Results The decision model of CARD is based the alignment score with a single ARG type. We discover the occasions where the model is likely to make false prediction, and then propose an optimization method on top of the current CARD model. The optimization is expected to raise the coherence with BLAST homology relationships and improve the confidence for identification of ARGs using the database. Conclusions The absence of public recognized benchmark makes it challenging to evaluate the performance of ARG identification. However, possible wrong predictions and methods for resolving the problem can be inferred by computational analysis of the identification method and the underlying reference sequences. We hope our work can bring insight to the mission of precise ARG type classifications.

scholarly journals Chronic exposure to triclosan sustains microbial community shifts and alters antibiotic resistance gene levels in anaerobic digesters

2016 ◽  
Vol 18 (8) ◽  
pp. 1060-1067 ◽  
Author(s):  
Daniel E. Carey ◽  
Daniel H. Zitomer ◽  
Anthony D. Kappell ◽  
Melinda J. Choi ◽  
Krassimira R. Hristova ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Microbial Community ◽  
Resistance Gene ◽  
Chronic Exposure ◽  
Antibiotic Resistance Gene ◽  
Anaerobic Digesters ◽  
Community Shifts

At environmentally relevant levels triclosan caused an increase inmexB, but had no impact onintI1.

scholarly journals Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistance

2013 ◽  
Vol 121 (9) ◽  
pp. 993-1001 ◽  
Author(s):  
Nicholas J. Ashbolt ◽  
Alejandro Amézquita ◽  
Thomas Backhaus ◽  
Peter Borriello ◽  
Kristian K. Brandt ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Antibiotic Resistance ◽  
Health Risk ◽  
Human Health ◽  
Health Risk Assessment ◽  
Human Health Risk ◽  
Human Health Risk Assessment ◽  
Environmental Development

scholarly journals Genetic Characteristics of Antibiotic Resistance Gene of Vibrio cholerae Isolated

2021 ◽  
Vol 10 (2) ◽  
pp. 89-95
Keyword(s):  
Antibiotic Resistance ◽  
Human Health ◽  
Vibrio Cholerae ◽  
Resistance Gene ◽  
Intestinal Mucosa ◽  
Antibiotic Resistance Gene ◽  
Cholera Vaccine ◽  
Genetic Characteristics ◽  
Factor Gene ◽  
Vibrio Spp

Vibrio cholerae is the factor of cholera disease in human and it has been becoming a serious problem in human health. This study was conducted to identify the genetic characteristics and antibiotic resistance of V. cholerae isolated in Tra Vinh Province. From the results, twenty-five (25) Vibrio spp. were isolated, including 6 strains of Vibrio (V.) cholerae (24%), 8 strains of V. paraheamolyticus (32%), 4 strains of V. vulnificus (16%), 5 strains of V. fluvialis (20%), and 2 strains of V. alginolyticus (8%). The serogroup results showed that all the 6 V. cholerae belonged to serogroup O1, with 50% positive to serotype Inaba, and 50% positive to Ogawa. No strain belonged to serogroup O139. The results also showed that 50% of V. cholerae were resistant to streptomycin and 33% were resistant to tetracycline and trimethoprim-sulfamethoxazole. Two of the 6 strains had an antibiotic resistance gene (gene tetA) encoding for a tetracycline-resistant factor. Gene blaSHV, gene aac(3)-IV and gene dhfrI encoding for β-lactam, aminoglycoside, trimethoprim resistant factors were not detected. Additionally, the results showed that adhesion indexes of V. cholerae strains T1 and T3 in the intestinal mucosa of rabbits shared the same antigens with the bacteria used to produce cholera vaccine (mORCVAX) available in Vietnam. V. cholerae was prevalent in the environment and clams in Tra Vinh province. Information from this research may be useful for further studies.

Human health risk assessment: application of the NORISC-HRA and ROME models at two test sites

2006 ◽  
Vol 14 (2) ◽  
pp. 559-570 ◽  
Author(s):  
F. Quercia ◽  
A. Vecchio ◽  
M. Falconi ◽  
L. Togni ◽  
E. Wcislo ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Human Health ◽  
Health Risk Assessment ◽  
Human Health Risk ◽  
Human Health Risk Assessment
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