Detection of anticancer drugs in wastewater effluents: Grab versus passive sampling

2021 ◽  
pp. 147477
Author(s):  
Maria B. Cristóvão ◽  
Andreia Bento-Silva ◽  
Maria R. Bronze ◽  
João G. Crespo ◽  
Vanessa J. Pereira
Keyword(s):  
Anticancer Drugs ◽  
Passive Sampling ◽  
Wastewater Effluents

Treatment of anticancer drugs in hospital and wastewater effluents using nanofiltration

2019 ◽  
Vol 224 ◽  
pp. 273-280 ◽  
Author(s):  
M.B. Cristóvão ◽  
J. Torrejais ◽  
R. Janssens ◽  
P. Luis ◽  
B. Van der Bruggen ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Wastewater Effluents

Toxicity testing in the development of anticancer drugs

2002 ◽  
Vol 3 (7) ◽  
pp. 440-441
Author(s):  
N Barnard
Keyword(s):  
Anticancer Drugs ◽  
Toxicity Testing

Toxicity testing in the development of anticancer drugs

2002 ◽  
Vol 3 (7) ◽  
pp. 439-440
Author(s):  
N Barrass
Keyword(s):  
Anticancer Drugs ◽  
Toxicity Testing

Erythrocytes and the transfer of anticancer drugs and metabolites: A possible relationship with therapeutic outcome

2001 ◽  
Vol 28 (2F) ◽  
pp. 24-28 ◽  
Author(s):  
Herlinde Dumez ◽  
Martin Highley ◽  
Gunther Guetens ◽  
Gert De Boeck ◽  
Axel Hanauske ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Therapeutic Outcome ◽  
Drugs And Metabolites

Cytotoxic Effect of the Combination of Gemcitabine and Atorvastatin Loaded in Microemulsion on the HCT116 Colon Cancer Cells

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Mayson H. Alkhatib ◽  
Dalal Al-Saedi ◽  
Wadiah S. Backer
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
In Vitro Study ◽  
Colon Cancer Cells ◽  
Apoptosis Detection ◽  
Hct116 Cells

The combination of anticancer drugs in nanoparticles has great potential as a promising strategy to maximize efficacies by eradicating resistant, reduce the dosage of the drug and minimize toxicities on the normal cells. Gemcitabine (GEM), a nucleoside analogue, and atorvastatin (ATV), a cholesterol lowering agent, have shown anticancer effect with some limitations. The objective of this in vitro study was to evaluate the antitumor activity of the combination therapy of GEM and ATVencapsulated in a microemulsion (ME) formulation in the HCT116 colon cancer cells. The cytotoxicity and efficacy of the formulation were assessed by the 3- (4,5dimethylthiazole-2-yl)-2,5-diphyneltetrazolium bromide (MTT) assay. The mechanism of cell death was examined by observing the morphological changes of treated cells under light microscope, identifying apoptosis by using the ApopNexin apoptosis detection kit, and viewing the morphological changes in the chromatin structure stained with 4′,6-diamidino-2-phenylindole (DAPI) under the inverted fluorescence microscope. It has been found that reducing the concentration of GEM loaded on ME (GEM-ME) from 5μM to 1.67μM by combining it with 3.33μM of ATV in a ME formulation (GEM/2ATV-ME) has preserved the strong cytotoxicity of GEM-ME against HCT116 cells. The current study proved that formulating GEM with ATV in ME has improved the therapeutic potential of GEM and ATV as anticancer drugs.

Highly Potent rhenium(I) Tricarbonyl Complexes with Dual Anticancer and Anti-Angiogenic Activity Against Colorectal Carcinoma

2020 ◽  
Author(s):  
Joachim Delasoie ◽  
Aleksandar Pavic ◽  
Noémie Voutier ◽  
Sandra Vojnovic ◽  
Aurélien Crochet ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Anticancer Drugs ◽  
Xenograft Model ◽  
Therapeutic Window ◽  
Low Doses ◽  
Sunitinib Malate ◽  
Angiogenic Activity ◽  
Antimetastatic Activity ◽  
Clinical Drugs

Synthesized and characterized a series of rhenium(I) trycarbonyl-based complexes with increased lipophilicity. Two of these novel compounds were discovered to possess remarkable anticancer, anti-angiogenic and antimetastatic activity <i>in vivo</i> (zebrafish-human CRC xenograft model), being effective at very low doses (1-3 µM). At doses as high as 250 µM the complexes did not provoke toxicity issues encountered in clinical anticancer drugs (cardio-, hepato-, and myelotoxicity). The two compounds exceed the antiproliferative and anti-angiogenic potency of clinical drugs cisplatin and sunitinib-malate, and display a large therapeutic window.

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