Embryonic cerebrospinal fluid formation and regulation

The influence of timolol upon cerebrospinal fluid formation rate has been examined in rats by the measurement of 22Na+ entry into this fluid after 10, 100, or 1000 μg∙kg−1 i.v, and in cats by the dye-dilution measurement of new fluid formation after 30, or 3000 μg∙kg−1 i.v., or 250 μg∙mL−1 in ventricular perfusate. In rats no change from control rates occurred. In the cats there appeared to be no effect of intraventricular timolol; however, a significant decrease of ~ 25% in the mean flow rate was seen after 40 min when drug was given i.v. at either dose level. A time study showed that no further decrease occurred within 5 h and that the observed decrease continued for at least 3 h. These findings are of interest in view of the ability of topical, intraocular, and i.v. timolol to reduce aqueous humor formation rate.

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ROENTGENOLOGIC STUDIES OF CEREBROSPINAL FLUID FORMATION IN THE DOG

American Journal of Roentgenology ◽

10.2214/ajr.105.4.756 ◽

1969 ◽

Vol 105 (4) ◽

pp. 756-762 ◽

Cited By ~ 4

Author(s):

D. GORDON POTTS ◽

RICHARD M. BERGLAND

Keyword(s):

Cerebrospinal Fluid ◽

Fluid Formation

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Cerebrospinal fluid formation and absorption in dehydrated sheep

AJP Renal Physiology ◽

10.1152/ajprenal.1998.275.2.f235 ◽

1998 ◽

Vol 275 (2) ◽

pp. F235-F238 ◽

Cited By ~ 3

Author(s):

Adam Chodobski ◽

Joanna Szmydynger-Chodobska ◽

Michael J. McKinley

Keyword(s):

Cerebrospinal Fluid ◽

Adaptive Response ◽

Venous Pressure ◽

Extracellular Fluid ◽

Cerebral Ventricles ◽

Central Venous ◽

Ventriculocisternal Perfusion ◽

Fluid Formation ◽

The Brain ◽

Csf Production

Cerebrospinal fluid (CSF) plays an important role in the brain’s adaptive response to acute osmotic disturbances. In the present experiments, the effect of 48-h dehydration on CSF formation and absorption rates was studied in conscious adult sheep. Animals had cannulas chronically implanted into the lateral cerebral ventricles and cisterna magna to enable the ventriculocisternal perfusion. A 48-h water deprivation altered neither CSF production nor resistance to CSF absorption. However, in the water-depleted sheep, intraventricular pressure tended to be lower than that found under control conditions. This likely resulted from decreased extracellular fluid volume and a subsequent drop in central venous pressure occurring in dehydrated animals. In conclusion, our findings provide evidence for the maintenance of CSF production during mild dehydration, which may play a role in the regulation of fluid balance in the brain during chronic hyperosmotic stress.

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Relationship between arterial and cisternal CSF oxygen tension in rabbits

AJP Renal Physiology ◽

10.1152/ajprenal.1979.236.3.f220 ◽

1979 ◽

Vol 236 (3) ◽

pp. F220-F225

Author(s):

L. Jankowska ◽

P. Grieb

Keyword(s):

Cerebrospinal Fluid ◽

Linear Regression ◽

Choroid Plexus ◽

Oxygen Tension ◽

Linear Regression Equation ◽

Mechanically Ventilated ◽

Fluid Formation ◽

And Function ◽

Ionic Exchanges ◽

Arterial Po2

Oxygen tension was measured in samples of blood and cisternal cerebrospinal fluid taken from anesthetized, paralyzed, and mechanically ventilated rabbits at various levels of arterial PO2. Cerebrospinal fluid oxygen tension (CSF PO2) was correlated with arterial PO2 (linear regression equation PCSFO2 = 0.2472 Pao2 + 42.34). During hypoxia CSF PO2 was higher than arterial PO2 in most experiments. These data can be attributed to the Bohr effect, which would increase the PO2 of the blood in choroid plexus capillaries as a result of its acidification. The acidification was suggested by Maren (Am. J. Physiol. 222: 885-889, 1972) to be a part of the ionic exchanges involved in cerebrospinal fluid formation. Such a mechanism may be of importance for supporting choroid plexus metabolism and function during hypoxia. This mechanism is most clearly seen in the rabbit.

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Experimental hydrocephalus: Cerebrospinal fluid formation and ventricular size as a function of intraventricular pressure

Journal of the Neurological Sciences ◽

10.1016/0022-510x(70)90042-0 ◽

1970 ◽

Vol 11 (1) ◽

pp. 81-91 ◽

Cited By ~ 37

Author(s):

A. Sahar ◽

G.M. Hochwald ◽

J. Ransohoff

Keyword(s):

Cerebrospinal Fluid ◽

Intraventricular Pressure ◽

Ventricular Size ◽

Experimental Hydrocephalus ◽

Fluid Formation

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Recent research into the nature of cerebrospinal fluid formation and absorption

Journal of Neurosurgery ◽

10.3171/jns.1983.59.3.0369 ◽

1983 ◽

Vol 59 (3) ◽

pp. 369-383 ◽

Cited By ~ 214

Author(s):

J. Gordon McComb

Keyword(s):

Cerebrospinal Fluid ◽

Clinical Setting ◽

Previous Knowledge ◽

Content Type ◽

Recent Information ◽

Fluid Formation ◽

Fine Print

✓ Recent information regarding the nature of bulk cerebrospinal fluid formation and absorption is reviewed, integrated with previous knowledge, and applied to the clinical setting.

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