scholarly journals Pachypodol attenuates Perfluorooctane sulphonate-induced testicular damage by reducing oxidative stress

2021 ◽  
Author(s):  
Muhammad Umar Ijaz ◽  
Ayesha Rauf ◽  
Shama Mustafa ◽  
Hussain Ahmed ◽  
Asma Ashraf ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Testicular Damage

Effect of selenium on carbimazole-induced testicular damage and oxidative stress in albino rats

2011 ◽  
Vol 25 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Saber Abdul Ruhman Sakr ◽  
Hoda Abdel-hafez Mahran ◽  
Amany Ebrahem Nofal
Keyword(s):  
Oxidative Stress ◽  
Albino Rats ◽  
Testicular Damage ◽  
And Oxidative Stress

scholarly journals Lutein Dietary Supplementation Attenuates Streptozotocin-induced testicular damage and oxidative stress in diabetic rats

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Amal J. Fatani ◽  
Salim S. Al-Rejaie ◽  
Hatem M. Abuohashish ◽  
Abdullah Al-Assaf ◽  
Mihir Y. Parmar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dietary Supplementation ◽  
Diabetic Rats ◽  
Testicular Damage ◽  
And Oxidative Stress

Protective role ofDiospyros lotuson cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats

Andrologia ◽  
2015 ◽  
Vol 48 (3) ◽  
pp. 308-317 ◽  
Author(s):  
S. Saral ◽  
E. Ozcelik ◽  
A. Cetin ◽  
O. Saral ◽  
N. Basak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Testicular Damage ◽  
Sperm Characteristics ◽  
Induced Changes ◽  
And Oxidative Stress

scholarly journals Aluminium phosphide-induced testicular toxicity through oxidative stress in Wistar rats: Ameliorative role of hesperidin

2018 ◽  
Vol 2 ◽  
pp. 239784731881279 ◽  
Author(s):  
Olusegun Kayode Afolabi ◽  
Adedoja Dorcas Wusu ◽  
Regina Ugbaja ◽  
John Olabode Fatoki
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Sperm Count ◽  
Sperm Parameters ◽  
Lipid Hydroperoxides ◽  
Testicular Toxicity ◽  
Testicular Damage ◽  
Histological Alterations ◽  
Aluminium Phosphide

The present study was designed to investigate aluminium phosphide (ALP)-induced testicular toxicity, including its effects on sperm parameters and histological alterations in Wistar rats, and the possible protective role of hesperidin (HSD). Oral administration of ALP at 1.15 mg/kg body weight (1/10 LD50) for 30 days resulted in a significant increase in testicular malondialdehyde, lipid hydroperoxides, and oxidized protein levels. These indicators of oxidative stress were accompanied by decreased activity of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, followed by a drastic reduction in the non-enzymatic antioxidant indices of glutathione and total antioxidant capacity when compared to control. Furthermore, ALP treatment produced a marked reduction in sperm count, motility and viability while increasing abnormal sperm morphology and adverse histopathological changes in testis. Co-administration with HSD significantly ameliorated ALP-induced testicular damage by suppressing oxidative stress indices and enhancing antioxidant status while also improving the sperm parameters and histological alterations in ALP-treated rats. The results of the present study indicated that testicular toxic effects of ALP are due to oxidative imbalance and that HSD could be a potential therapeutic agent against ALP-induced testicular damage.

scholarly journals Potential role of punicalagin against oxidative stress induced testicular damage

2016 ◽  
Vol 18 (4) ◽  
pp. 627 ◽  
Author(s):  
Fei Sun ◽  
Faiza Rao ◽  
Hui Tian ◽  
Wenqing Li ◽  
Helong Hung
Keyword(s):  
Oxidative Stress ◽  
Potential Role ◽  
Testicular Damage

scholarly journals Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-κB Pathways

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Xiandong Zhu ◽  
Feixia Guo ◽  
Hengjie Tang ◽  
Chongchu Huang ◽  
Gangyin Xie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Islet Transplantation ◽  
Group Versus ◽  
Myocardial Damage ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Testicular Damage ◽  
Sod Activity ◽  
Respective Treatment ◽  
Testicular Injury

Testicular structural and functional impairment is a serious complication in male diabetes mellitus (DM) patients that leads to impaired fertility in adulthood. In contrast to other endocrine therapies, islet transplantation (IT) can effectively prevent and even reverse diabetic nephropathy and myocardial damage. However, whether IT can alleviate diabetes-induced testicular injury remains unclear. In this study, we sought to investigate the effect of IT on diabetes-induced testicular damage. A diabetic rat model was established by streptozotocin injection. DM, IT, and insulin treatment (INS) groups were compared after 4 weeks of respective treatment. We confirmed that IT could effectively attenuate diabetes-induced testicular damage and recover sperm counts more extensively compared with INS in diabetic rats. In addition, significantly higher levels of superoxide dismutase (SOD) activity and lower contents of malondialdehyde (MDA) were detected in the testes of the IT group versus diabetic rats. Mechanism studies revealed that IT significantly activates the expression of Nrf-2, HO-1, and NQO-1 and inhibits upregulation of the NF-κB expression in response to DM, while INS only exhibit slight impact on the protein expression. Therefore, we speculate that IT may prevent the progression of testicular damage by downregulating oxidative stress and inhibiting inflammation via Nrf-2/HO-1 and NF-κB pathways.

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