scholarly journals Rational design of a nitroreductase-activatable two-photon fluorescent probe for hypoxia imaging in cell and in vivo

2020 ◽  
Vol 310 ◽  
pp. 127755 ◽  
Author(s):  
Yue Wang ◽  
Li Zhang ◽  
Yan Huang ◽  
Xiaoyan Wang ◽  
Liangwei Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Rational Design ◽  
Hypoxia Imaging ◽  
Two Photon

scholarly journals 99mTc Labelling Strategies for the Development of Potential Nitroimidazolic Hypoxia Imaging Agents

Inorganics ◽  
2019 ◽  
Vol 7 (11) ◽  
pp. 128 ◽  
Author(s):  
Giglio ◽  
Rey
Keyword(s):  
Rational Design ◽  
Biological Properties ◽  
Fine Tuning ◽  
Oxidation States ◽  
Hypoxia Imaging ◽  
Biological Target ◽  
99Mtc Radiopharmaceuticals ◽  
99Mtc Labelling

Technetium-99m has a rich coordination chemistry that offers many possibilities in terms of oxidation states and donor atom sets. Modifications in the structure of the technetium complexes could be very useful for fine tuning the physicochemical and biological properties of potential 99mTc radiopharmaceuticals. However, systematic study of the influence of the labelling strategy on the “in vitro” and “in vivo” behaviour is necessary for a rational design of radiopharmaceuticals. Herein we present a review of the influence of the Tc complexes’ molecular structure on the biodistribution and the interaction with the biological target of potential nitroimidazolic hypoxia imaging radiopharmaceuticals presented in the literature from 2010 to the present. Comparison with the gold standard [18F]Fluoromisonidazole (FMISO) is also presented.

Specific Two-Photon Fluorescent Probe for Cysteine Detection in Vivo

2021 ◽  
pp. 120521
Author(s):  
Yu-Xu Tu ◽  
Vijay Natarajan ◽  
Han-Xiang Ko ◽  
Yuan-Pin Lo ◽  
Velmathi Sivan ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Two Photon

Rational design of a lysosomal-targeted ratiometric two-photon fluorescent probe for imaging hydrogen polysulfides in live cells

2020 ◽  
Vol 173 ◽  
pp. 107877 ◽  
Author(s):  
Qingxin Han ◽  
Xuan Liu ◽  
Xuechuan Wang ◽  
Ruojun Yin ◽  
Huie Jiang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Rational Design ◽  
Live Cells ◽  
Two Photon

A dual-emission two-photon fluorescent probe for specific-cysteine imaging in lysosomes and in vivo

2019 ◽  
Vol 293 ◽  
pp. 247-255 ◽  
Author(s):  
Yinliang Huang ◽  
Qifeng Ren ◽  
Shanqing Li ◽  
Yan Feng ◽  
Wan Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Dual Emission ◽  
Two Photon

Rational Design of a Two-Photon Ratiometric Fluorescent Probe for Hypochlorous Acid with a Large Stokes Shift

2020 ◽  
Vol 92 (16) ◽  
pp. 11029-11034 ◽  
Author(s):  
Long He ◽  
Haiqing Xiong ◽  
Benhua Wang ◽  
Yun Zhang ◽  
Jingpei Wang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Rational Design ◽  
Hypochlorous Acid ◽  
Stokes Shift ◽  
Large Stokes Shift ◽  
Two Photon ◽  
Ratiometric Fluorescent Probe

Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe

2020 ◽  
Vol 56 (90) ◽  
pp. 14075-14078
Author(s):  
Jintao Zhao ◽  
Yuan Qu ◽  
Hao Gao ◽  
Miao Zhong ◽  
Xinming Li ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Thioredoxin Reductase ◽  
Stroke Model ◽  
Two Photon

The first two-photon fluorescent probe (TP-TRFS) is reported, and it was successfully used in vivo.

scholarly journals Rational design of small indolic squaraine dyes with large two-photon absorption cross section

2015 ◽  
Vol 6 (1) ◽  
pp. 761-769 ◽  
Author(s):  
Chun-Lin Sun ◽  
Qing Liao ◽  
Ting Li ◽  
Jun Li ◽  
Jian-Qiao Jiang ◽  
...  
Keyword(s):  
Cross Section ◽  
Rational Design ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Squaraine Dyes ◽  
Two Photon ◽  
Bio Imaging

Assisted by theoretical analysis, we designed a small indolic squaraine with δ > 8000 GM at 780 nm, which is ideal for both in vitro and in vivo bio-imaging applications.

Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo

Biomaterials ◽  
2015 ◽  
Vol 53 ◽  
pp. 522-531 ◽  
Author(s):  
Pingyu Zhang ◽  
Huaiyi Huang ◽  
Yu Chen ◽  
Jinquan Wang ◽  
Liangnian Ji ◽  
...  
Keyword(s):  
Hypoxia Imaging ◽  
Luminescent Probes ◽  
Two Photon
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