scholarly journals An Old Drug for New Ideas: Metformin Promotes Adult Neurogenesis and Spatial Memory Formation

2012 ◽  
Vol 11 (1) ◽  
pp. 5-6 ◽  
Author(s):  
Matthew B. Potts ◽  
Daniel A. Lim
Keyword(s):  
Spatial Memory ◽  
Adult Neurogenesis ◽  
Memory Formation ◽  
New Ideas

scholarly journals Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation

2020 ◽  
Vol 323 ◽  
pp. 113095 ◽  
Author(s):  
Albert Giralt ◽  
Verónica Brito ◽  
Monica Pardo ◽  
Sara E. Rubio ◽  
Lucile Marion-Poll ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Formation

scholarly journals Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus

2012 ◽  
Vol 109 (23) ◽  
pp. E1499-E1508 ◽  
Author(s):  
G. Quadrato ◽  
M. Benevento ◽  
S. Alber ◽  
C. Jacob ◽  
E. M. Floriddia ◽  
...  
Keyword(s):  
T Cells ◽  
Spatial Memory ◽  
Memory Formation ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Adult Born Neurons

scholarly journals Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question

2021 ◽  
Vol 13 ◽  
Author(s):  
Domenica Donatella Li Puma ◽  
Roberto Piacentini ◽  
Claudio Grassi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Adult Neurogenesis ◽  
Memory Formation ◽  
Hippocampal Neurogenesis ◽  
Synaptic Function ◽  
Adult Hippocampal Neurogenesis ◽  
Amyloid Β Protein

Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal memory formation. Several studies associated altered hippocampal neurogenesis with aging and Alzheimer's disease (AD). However, whether amyloid-β protein (Aβ)/tau accumulation impairs adult hippocampal neurogenesis and, consequently, the hippocampal circuitry, involved in memory formation, or altered neurogenesis is an epiphenomenon of AD neuropathology contributing negligibly to the AD phenotype, is, especially in humans, still debated. The detrimental effects of Aβ/tau on synaptic function and neuronal viability have been clearly addressed both in in vitro and in vivo experimental models. Until some years ago, studies carried out on in vitro models investigating the action of Aβ/tau on proliferation and differentiation of hippocampal neural stem cells led to contrasting results, mainly due to discrepancies arising from different experimental conditions (e.g., different cellular/animal models, different Aβ and/or tau isoforms, concentrations, and/or aggregation profiles). To date, studies investigating in situ adult hippocampal neurogenesis indicate severe impairment in most of transgenic AD mice; this impairment precedes by several months cognitive dysfunction. Using experimental tools, which only became available in the last few years, research in humans indicated that hippocampal neurogenesis is altered in cognitive declined individuals affected by either mild cognitive impairment or AD as well as in normal cognitive elderly with a significant inverse relationship between the number of newly formed neurons and cognitive impairment. However, despite that such information is available, the question whether impaired neurogenesis contributes to AD pathogenesis or is a mere consequence of Aβ/pTau accumulation is not definitively answered. Herein, we attempted to shed light on this complex and very intriguing topic by reviewing relevant literature on impairment of adult neurogenesis in mouse models of AD and in AD patients analyzing the temporal relationship between the occurrence of altered neurogenesis and the appearance of AD hallmarks and cognitive dysfunctions.

Blockade of N-methyl-d-aspartate receptors in the insular cortex disrupts taste aversion and spatial memory formation

Neuroscience ◽  
1999 ◽  
Vol 89 (3) ◽  
pp. 751-758 ◽  
Author(s):  
H Gutiérrez ◽  
E Hernández-Echeagaray ◽  
V Ramı́rez-Amaya ◽  
F Bermúdez-Rattoni
Keyword(s):  
Spatial Memory ◽  
Taste Aversion ◽  
Insular Cortex ◽  
Memory Formation

scholarly journals Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain

2019 ◽  
Vol 26 (3) ◽  
pp. 77-83 ◽  
Author(s):  
Edwin W. Wong ◽  
Stephen D. Glasgow ◽  
Lianne J. Trigiani ◽  
Daryan Chitsaz ◽  
Vladimir Rymar ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Formation ◽  
Mammalian Brain ◽  
Adult Mammalian Brain

scholarly journals Decrease of Rab11 prevents the correct dendritic arborization, synaptic plasticity and spatial memory formation

2020 ◽  
Vol 1867 (9) ◽  
pp. 118735 ◽  
Author(s):  
Sebastian O. Siri ◽  
Victoria Rozés-Salvador ◽  
Emilce Artur de la Villarmois ◽  
Marisa S. Ghersi ◽  
Gonzalo Quassollo ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Spatial Memory ◽  
Memory Formation ◽  
Dendritic Arborization

scholarly journals T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-β peptide

2009 ◽  
Vol 157 (3) ◽  
pp. 451-463 ◽  
Author(s):  
Tatsuo Kimura ◽  
Phuong Thi Hong Nguyen ◽  
Son Anh Ho ◽  
Anh Hai Tran ◽  
Taketoshi Ono ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Adult Neurogenesis ◽  
Amyloid Β ◽  
Amyloid Β Peptide

scholarly journals Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory

2014 ◽  
Vol 8 ◽  
Author(s):  
Jorge Valero ◽  
Giorgia Mastrella ◽  
Ismael Neiva ◽  
Silvia Sánchez ◽  
João O. Malva
Keyword(s):  
Spatial Memory ◽  
Adult Neurogenesis ◽  
Systemic Administration ◽  
Long Term Effects

scholarly journals Involvement of BDNF Receptor TrkB in Spatial Memory Formation

2003 ◽  
Vol 10 (2) ◽  
pp. 108-115 ◽  
Author(s):  
M. Mizuno
Keyword(s):  
Spatial Memory ◽  
Memory Formation
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